DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho and RHBDF2

DIOPT Version :9

Sequence 1:	NP_001261255.1	Gene:	rho / 38168	FlyBaseID:	FBgn0004635	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_078875.4	Gene:	RHBDF2 / 79651	HGNCID:	20788	Length:	856	Species:	Homo sapiens

Alignment Length:	364	Identity:	81/364 - (22%)
Similarity:	131/364 - (35%)	Gaps:	122/364 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 KVDLGQEKEKEASQEEEHATAAKETIIDIPAA---------------CSS---SSNSSSYDTDCS 58
            |.||||::...|...::..|..:      ||:               |:.   |:::.....||.
Human   536 KSDLGQKRTSGAVCHQDPRTCEE------PASSGAHIWPDDITKWPICTEQARSNHTGFLHMDCE 594

  Fly    59 TASSTCC----------TR---QGEHIYMQREAIPATPLPESEDIGLLKYVHRQHWPWFILVISI 110
            .....||          ||   :..|.|...||.            |...||
Human   595 IKGRPCCIGTKGSCEITTREYCEFMHGYFHEEAT------------LCSQVH------------- 634

  Fly   111 IEIAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLF 175
                  ..|:..      || :|..:..|    ||   |.:|.:..:||||...|...::|.|:.
Human   635 ------CLDKVC------GL-LPFLNPEV----PD---QFYRLWLSLFLHAGVVHCLVSVVFQMT 679

  Fly   176 FGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFL-----VGASGGVYALLAAHLANITLNY 235
            ....||.:.|..||.:|::.....|:|.     |.:||     ||.:|..:.|||.....:..::
Human   680 ILRDLEKLAGWHRIAIIFILSGITGNLA-----SAIFLPYRAEVGPAGSQFGLLACLFVELFQSW 739

  Fly   236 AHMK---SASTQLGSVVIFVSCDLGYALYTQYFDGSAFAKG--PQVSYIAHLTGALAGLTIGFLV 295
            ..::   .|...|.::|:|:                 |..|  |.:..|||:.|.|:||.:.|..
Human   740 PLLERPWKAFLNLSAIVLFL-----------------FICGLLPWIDNIAHIFGFLSGLLLAFAF 787

  Fly   296 LK--NFGHRE-YEQ----LIWWLAL-GVYCAFTVFAIVF 326
            |.  .||..: |.:    |:..||. |::.|..::..::
Human   788 LPYITFGTSDKYRKRALILVSLLAFAGLFAALVLWLYIY 826

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho	NP_001261255.1	Rhomboid	144..297	CDD:279958	43/162 (27%)
RHBDF2	NP_078875.4	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..115
		Rhomboid_SP	128..334	CDD:289371
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	165..184
		Involved in interaction with FRMD8. /evidence=ECO:0000269\|PubMed:29897333	191..271
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	531..553		6/16 (38%)
		Rhomboid	648..789	CDD:279958	44/169 (26%)
		GtrA	748..832	CDD:303012	24/96 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	4	3.820