DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho and rhbdl3

DIOPT Version :9

Sequence 1:	NP_001261255.1	Gene:	rho / 38168	FlyBaseID:	FBgn0004635	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	XP_005166241.1	Gene:	rhbdl3 / 550128	ZFINID:	ZDB-GENE-050417-2	Length:	407	Species:	Danio rerio

Alignment Length:	235	Identity:	92/235 - (39%)
Similarity:	142/235 - (60%)	Gaps:	15/235 - (6%)

- Green bases have known domain annotations that are detailed below.

  Fly   102 PWFILVISIIEIAIFAY-----DRYTMPAQN-FGLPVPIPSDSVLVYRPDRRLQVWRFFSYMFLH 160
            ||.:|.|:|.|:.:|.|     :|:.:...: :.|..|:|      |.|..|.|.|||.||:|:|
Zfish   166 PWLMLAITITEVVVFMYYGLQLNRWVLQVSSPYFLKGPLP------YHPQLRAQAWRFLSYIFMH 224

  Fly   161 ANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFLVGASGGVYALLA 225
            |...|||.|:.:||..|:|||::||..|||::|:.|..||||..||.|....:||:|||||||::
Zfish   225 AGIEHLGLNMAMQLLVGVPLEMVHGALRIGLVYVCGALAGSLAVSVTDMTAPVVGSSGGVYALVS 289

  Fly   226 AHLANITLNYAHMKSAST--QLGSVVIFVSCDLGYALYTQYFDGSAFAKGPQVSYIAHLTGALAG 288
            |||||:.:|::.||....  ::...::.:|.:.|.|::.:.:. .||...|..|::|||.|...|
Zfish   290 AHLANVVMNWSGMKCQFKLFRMAMALVCMSVEFGRAVWLRCYP-PAFPPCPNPSFVAHLGGVAVG 353

  Fly   289 LTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIVFNL 328
            ||:|.:||:|:..|..||.::|:...||..|.:..|.:|:
Zfish   354 LTLGVVVLQNYEQRLQEQSLFWIFFSVYTLFILCGIFWNI 393

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho	NP_001261255.1	Rhomboid	144..297	CDD:279958	68/154 (44%)
rhbdl3	XP_005166241.1	EFh	35..95	CDD:238008
		EF-hand_7	35..94	CDD:290234
		Rhomboid	208..362	CDD:279958	68/154 (44%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170577612
Domainoid	1	1.000	148	1.000	Domainoid score	I4412
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	1	1.000	-	-		mtm6530
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	9	8.950