DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho and Rhbdf2

DIOPT Version :9

Sequence 1:	NP_001261255.1	Gene:	rho / 38168	FlyBaseID:	FBgn0004635	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001100537.2	Gene:	Rhbdf2 / 303690	RGDID:	1309699	Length:	825	Species:	Rattus norvegicus

Alignment Length:	389	Identity:	72/389 - (18%)
Similarity:	136/389 - (34%)	Gaps:	135/389 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly     1 MENLTQNVNET-------KVDLGQEKEKEASQEEEHATAAKETIIDIPAACSSSSNSSSY----- 53
            ::.|.::.:||       :.|.....:.:.||::..|....:.    |..|...::|.::
  Rat   479 IQTLKKDCSETLATFVKWQNDTEPSDKSDLSQKQPSAVVCHQD----PRTCEEPASSGAHIWPDD 539

  Fly    54 -------------------DTDCSTASSTCC----------TR---QGEHIYMQREAIPATPLPE 86
                               ..||......||          ||   :..|.|...||...:.:..
  Rat   540 ITKWPICTEQAQSNRTGLLHIDCKIKGRPCCIGTKGSCEITTREYCEFMHGYFHEEATLCSQVHC 604

  Fly    87 SEDI-GLLKYVHRQHWPWFILVISIIEIAIFAYDRYTMPAQNFGLPVPIPSDSVLVYRPDRRLQV 150
            .::: |||.:::.:                                  ||.            |.
  Rat   605 LDEVCGLLPFLNPE----------------------------------IPD------------QF 623

  Fly   151 WRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVFAGSLGTSVVDSEVFL-- 213
            :|.:..:||||...|...::|.|:.....||.:.|..||.:|::.....|:|.     |.:||
  Rat   624 YRIWLSLFLHAGIVHCLVSVVFQMTILRDLEKLAGWHRISIIFILSGITGNLA-----SAIFLPY 683

  Fly   214 ---VGASGGVYALLAAHLANITLNYAHMK---SASTQLGSVVIFVSCDLGYALYTQYFDGSAFAK 272
               ||.:|..:.|||.....:..::..::   .|...|.::|:|:                 |..
  Rat   684 RAEVGPAGSQFGLLACLFVELFQSWQLLERPWKAFFNLSAIVLFL-----------------FIC 731

  Fly   273 G--PQVSYIAHLTGALAGLTIGFLVLK--NFG--HREYEQLIWWLAL----GVYCAFTVFAIVF 326
            |  |.:..|||:.|.|:|:.:.|..|.  .||  .|..:|.:..::|    |::.:..::..::
  Rat   732 GLLPWIDNIAHIFGFLSGMLLAFAFLPYITFGTSDRYRKQALILVSLLVFAGLFASLVLWLYIY 795

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho	NP_001261255.1	Rhomboid	144..297	CDD:279958	40/162 (25%)
Rhbdf2	NP_001100537.2	Rhomboid_SP	98..302	CDD:403706
		Rhomboid	617..758	CDD:396315	42/208 (20%)
		MFS	718..>808	CDD:421695	20/95 (21%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X418
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	4	3.820