DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment rho and rom-2

DIOPT Version :9

Sequence 1:	NP_001261255.1	Gene:	rho / 38168	FlyBaseID:	FBgn0004635	Length:	355	Species:	Drosophila melanogaster
Sequence 2:	NP_001366679.1	Gene:	rom-2 / 183564	WormBaseID:	WBGene00004401	Length:	348	Species:	Caenorhabditis elegans

Alignment Length:	264	Identity:	80/264 - (30%)
Similarity:	144/264 - (54%)	Gaps:	21/264 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    73 YMQREAIPATPLPESEDIGLLKYVHRQHW---PWFILVISIIEIAIFAYDRYTM-PAQNFGLPVP 133
            |:.|.|:..|  |:::.|.:...:.|...   |.|::.:||:::|.:.|  |.: .::...|..|
Worm    92 YLFRAALTVT--PKNQRIHVFSELQRYKCVPPPIFLIFLSIVQLAFYLY--YVVDSSEGVWLSGP 152

  Fly   134 IPSDSVLVYRPDRRLQVWRFFSYMFLHANWFHLGFNIVIQLFFGIPLEVMHGTARIGVIYMAGVF 198
            ||:.|.|:.......::||.|:|..::...||:.|||:|||..|:|||::| ..||.::|..||.
Worm   153 IPTMSPLIVSQYHLPELWRLFTYCLINVGIFHIIFNILIQLAIGVPLELVH-RWRIYILYFMGVL 216

  Fly   199 AGSLGTSVVDSEVFLVGASGGVYALLAAHLANITLNYAHMKSASTQLGSVVIFVSCDLGYALYTQ 263
            .||:.:..:|..|||.|.:.|.::|:|:|:..|..|:..|::|:.:|..:::|.:.|...|:|.:
Worm   217 FGSILSLALDPTVFLCGGAAGSFSLIASHITTIATNFKEMENATCRLPILIVFAALDYVLAVYQR 281

  Fly   264 YFDGSAFAKGP---QVSYIAHLTGALAGLTIGFLVLKNFGHREYEQLIWWLALGVYCAFTVFAIV 325
            :|       .|   :||...||.|.:||:...|::.:......:..:.:|::| |...|.: ||.
Worm   282 FF-------APRIDKVSMYGHLGGLVAGILFTFILFRGSKPSRFYTVSFWVSL-VLSGFFI-AIC 337

  Fly   326 FNLI 329
            ..||
Worm   338 ITLI 341

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
rho	NP_001261255.1	Rhomboid	144..297	CDD:279958	52/155 (34%)
rom-2	NP_001366679.1	EF-hand_7	21..82	CDD:404394
rom-2	NP_001366679.1	Rhomboid	165..311	CDD:396315	52/153 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160162539
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG0705
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5174
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D1253228at2759
OrthoFinder	1	1.000	-	-		FOG0000995
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	1	0.900	-	-		OOG6_107191
Panther	1	1.100	-	-	O	PTHR45840
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	10	9.660