DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and stag1b

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	XP_692120.3	Gene:	stag1b / 563669	ZFINID:	ZDB-GENE-030131-1393	Length:	1256	Species:	Danio rerio

Alignment Length:	1131	Identity:	266/1131 - (23%)
Similarity:	460/1131 - (40%)	Gaps:	257/1131 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ISFDDAVLNDSQASNQMDFEIREECSIAPNDEPVCVDGTVG------------DATNKSLLQMIL 56
            |:.|..||.||....|.| .|....|::..|:|     .||            .|.||
Zfish     2 INSDFPVLQDSSNDGQGD-TISLAMSVSELDDP-----EVGKGKKKRGRPGKQGAANK------- 53

  Fly    57 SRKRLSPTNK---------------------------RNSHIESVAKYWGEFYLDSPTAALVALL 94
             :.|.||.:|                           ..|.::||...|.|.|......||:.|:
Zfish    54 -KARRSPVDKGGRRPNGVAHQNGEGTDPSTLFEVVKQGKSAMQSVIDDWIESYKQDRDLALLDLI 117

  Fly    95 QFVVEVSGSHYQIPDDTSMPFSYSDILSNSSSHFSNTHIYPLIRKPADVFVNQVGSFLNALLLVA 159
            .|.:..||....:..:.                |.|.....:|||..:.|....|.:  .|.:..
Zfish   118 NFFIHCSGCKGTVRIEM----------------FRNMQNAEIIRKMTEEFDEDSGDY--PLTMTG 164

  Fly   160 ---NKFRSDSYQLFLV-----------------QLTNFVMACSESNIRTFRHTATMIGLKIMTIL 204
               .|||.:..:..:|                 .:.:.:...|:|.:|.||||:|:..:|:||.|
Zfish   165 PQWKKFRYNFCEFIMVLIRQCQYSIIYDEYMMDTVISLLTGLSDSQVRAFRHTSTLAAMKLMTAL 229

  Fly   205 -----------------------------------------SDLKSLDDEIAMTVWMQMFNSMFV 228
                                                     .:|:...|||. .:...:|..:||
Zfish   230 VNVALNLSINQDNTQRQYEAERNKVAGKRANEKLELLLEKRKELQENQDEIE-NMMNSIFKGIFV 293

  Fly   229 ARSRDIVTDIRLLCISELGQWFARYPHCHLQPTSLRIFYEALNDGSGDV-IQCSLDNISVLCRKD 292
            .|.||.:.:||.:||.|:|.|...|....|..:.|:.....|:|..|:| ::| |..:..|....
Zfish   294 HRYRDAIAEIRAICIEEIGVWMKLYSDAFLNDSYLKYVGWTLHDRQGEVRLKC-LKALQTLYTNR 357

  Fly   293 VLFSEIVALTSEFREILVELCLGKEDAIAEKSVQFLTHFHVLSAEILTDDVCRVLEQLIMAANRG 357
            .|:.::...|:.|::.:|.:.|.||..:|.::::.:|.....|.:.|:::.|..:..|:.:|:|.
Zfish   358 ELYPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEDALSNEDCENVYHLVYSAHRP 422

  Fly   358 LAQAAADLFILR-------------------RNGLDGETFCQRVKHLLQLFIECG-HEQADYLVD 402
            :|.||.: |:.|                   ||..:|..    :|.|:..|:|.. ||.|.||||
Zfish   423 VAVAAGE-FLHRKLFSRHDPQAEEALAKRRGRNSPNGNL----IKMLVLFFLESELHEHAAYLVD 482

  Fly   403 SLIDNC-ELVLDWKSMIAVLLENPKSRE--LSDIHCSSLIAILLAGVKQATAGEIPPGRYT---- 460
            ||.|:. :|:.||..|:.:|||:|...|  |.|.|.|:||.:::..::||.....|.||.|
Zfish   483 SLWDSSHDLLKDWDCMVELLLEDPVQGEEVLGDRHESALIELMVCTIRQAAEAHPPVGRGTGKRV 547

  Fly   461 ---KDLKREPRQGAQERATKCLAPVLPELLRTYANRLQDIERLLELPKYFCFDYYHEQNRMGQLN 522
               |:.|.:...  :.|.|:.|...||.||..|....:.:..||::|:||..:.|........|:
Zfish   548 LTAKEKKTQIDD--KNRLTEHLIVALPMLLSKYQVDAEKVANLLQIPQYFDLEVYSSGRMEKHLD 610

  Fly   523 ELVEHFELIIFDQTSSTTVLQITVKTLEFL--------NRMIPIPLTKQLLNSAVTNYKMAWHRT 579
            .|::...::: ::.:...||:...||...|        ||   :.:.:..|...:|: |.| |..
Zfish   611 ALLKQIRVVV-EKHAEMEVLEACSKTYSILCSEEYTIMNR---VDIARSQLIDELTD-KFA-HSV 669

  Fly   580 QD--TSPSRSTHNESNRLLATLRLLTVLSGHFNLSKWDLTEPLLFSLKMLLRQRRLPNGDDLPPE 642
            :|  .....:..::...:|:||:.||......:|:||||.:.....|||.:.|..:|  :.:..:
Zfish   670 EDLLQEGEEADDDDIYNVLSTLKKLTAFHNAHDLTKWDLFKNCYRLLKMGIEQGSMP--EQIAVQ 732

  Fly   643 AFSLYLKACFCCLCWDMENLEGTALNNVDMDEYCD------VLHHNLEDYLYVTFSLVGKSNTEP 701
            |    |:.....:.|.:          |.:.|.|.      .|...::.:|.|....:...|| |
Zfish   733 A----LQCSHYSILWQL----------VKITEGCPSKDDLLALRRVVKSFLAVCQQCLSNVNT-P 782

  Fly   702 LAYPCFSYTCDLFVLHGN-LCGSSNPSIRSVAHVPSGNELDILEGFLMEH-FLELSPSDLMLETN 764
            :....|...|||.::..: |.......::.:...|.|:..:.|..|:::| |::....:..:|.:
Zfish   783 VKEQAFMLLCDLLMIFSHQLVSGGREGLQPLVFNPDGSLQNELLNFVLDHVFIDQDDENQSMEGD 847

  Fly   765 SDQ-------LQRIRSILTSYLKVVCLGVVPTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNP 822
            .:.       |.:.|::|.::.|::...:|....|:..::.|:||:..:||:::.::....|.:.
Zfish   848 EEDEANKIEALHKRRNLLAAFCKLIIYDIVDMPAAADIFKQYMKYYNDYGDIIKETLSKTRQMDK 912

  Fly   823 IHFAMTMLHTCLLLYAKVFPDD-------TRHAAGQRALRPAEFSELMELANRLAKILISNPMEH 880
            |..|.|::.:...|:.::..|.       :.|.:|           :.|||.|.|.....:.::.
Zfish   913 IQCAKTLILSLQQLFNELIQDQGPNLDRTSSHVSG-----------IKELARRFALTFGLDQIKT 966

  Fly   881 RECVIALHRSGILFVFELAQ-KQPTEATKKLPFLRVLKVFVPLLLVQDKTRILNFFEPY------ 938
            ||.|..||:.||.|.|::.. |.|......|.||.||..|...||.|||..:.::.|.:
Zfish   967 REAVATLHKDGIEFAFKVPNPKGPEYPPPNLAFLEVLCEFSSKLLRQDKKTVHSYLEKFMTEYMM 1031

  Fly   939 ---EQLIIPTCNRNDIAHLKEYRNAL 961
               |.:.:|         |..|||:|
Zfish  1032 ERREDVWLP---------LIAYRNSL 1048

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	26/143 (18%)
stag1b	XP_692120.3	IRR1	10..>394	CDD:227824	88/417 (21%)
stag1b	XP_692120.3	STAG	156..264	CDD:285686	18/109 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170595632
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
ZFIN	0	0.000	Not matched by this tool.
	9	8.820