DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and Stag3

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_058660.2	Gene:	Stag3 / 50878	MGIID:	1355311	Length:	1240	Species:	Mus musculus

Alignment Length:	1088	Identity:	256/1088 - (23%)
Similarity:	448/1088 - (41%)	Gaps:	208/1088 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    13 DSQASNQ-MDFE------IREECSIAPNDEPVCVDG-----------TVGDATNKSLLQMILSRK 59
            ||.::|: .|||      :::..:..|   |..|..           :.|:..|:|    :.|..
Mouse    56 DSPSTNEDSDFEDSLRRNVKKRAAKQP---PKAVPAAKHRKKQSRIVSSGNGKNES----VPSTN 113

  Fly    60 RLSPTNK-RNSHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPDDTSMPFSYSDILSN 123
            .|....| ..|.::|:...|.:.|.....|..:.|:.|.:...|....:..:.....|.|:|:.:
Mouse   114 YLFDAVKAARSCMQSLVDEWLDNYKQDENAGFLELINFFIRACGCKSTVTPEMFKTMSNSEIIQH 178

  Fly   124 SSSHFS-NTHIYPLIRKPADVFVNQVGSFLNAL-LLVANKFRSDSYQLF-LVQLTNFVMACSESN 185
            .:..|: ::..||| ..|...:....|||...: .||.....|..|..| :..|.:.::..|:|.
Mouse   179 LTEEFNEDSGDYPL-TAPGPSWKKFQGSFCEFVKTLVYQCQYSLLYDGFPMDDLISLLIGLSDSQ 242

  Fly   186 IRTFRHTATMIGLKIMTIL-------------------------------SDLKSL--------- 210
            :|.||||:|:..:|:||.|                               ..|:||
Mouse   243 VRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRAPERLESLLEKRKEFQE 307

  Fly   211 ---DDEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFARYPHCHLQPTSLRIFYEALND 272
               |.|..|..   :|..:||.|.|||:.:||.:||.|:|.|...|....|..:.|:.....|:|
Mouse   308 NQEDIEGMMNA---IFRGVFVHRYRDILPEIRAICIEEIGYWMQSYSTSFLNDSYLKYIGWTLHD 369

  Fly   273 GSGDV-IQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKEDAIAEKSVQFLTHFHVLSA 336
            ...:| ::| :..::.|.....|...:...|:.|::.:|.:.:.:|..:|.::::.||.......
Mouse   370 KHKEVRLKC-VKALAGLYSNQELSLRMELFTNRFKDRMVSMVMDRECEVAVEAIRLLTLILKNME 433

  Fly   337 EILTDDVCRVLEQLIMAANRGLAQAAADLFIL------------------RRNGLDGETFCQRVK 383
            .:||...|..:..::..:||.:|.:|.: |:.                  ||:....:||   :.
Mouse   434 GVLTSADCEKIYSIVYISNRAMASSAGE-FVYWKIFHPECGAKAVSDRERRRSPQAQKTF---IY 494

  Fly   384 HLLQLFIEC-GHEQADYLVDSLIDNC--ELVLDWKSMIAVLLENPKSRELSDIHCSSLIAILLAG 445
            .||..|:|. .|..|.||||||.| |  ..:.||:|:..:||:  |.:.|.|:....||.||::.
Mouse   495 LLLAFFMESEHHNHAAYLVDSLWD-CAGSYLKDWESLTNLLLQ--KDQNLGDMQERMLIEILVSS 556

  Fly   446 VKQATAGEIPPGRYT--KDLKREPRQGAQERATKC---------LAPVLPELLRTYANRLQDIER 499
            .:||..|..|.||.|  |.|.      |:||..:.         |.|:||:||..::...:::..
Mouse   557 ARQAAEGHPPVGRITGKKSLT------AKERKLQAYDKMKLAEHLIPLLPQLLAKFSADAENVAP 615

  Fly   500 LLELPKYFCFDYYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLE-------------- 550
            ||:|..||....|..|       .|.:|.||:: .|.....|..:..:.||
Mouse   616 LLQLLSYFDLSIYCTQ-------RLEKHLELLL-QQLQEVVVKHVEPEVLEAAAHALYLLCKPEF 672

  Fly   551 -FLNRMIPIPLTKQLLNSAVTNYKMAWHRTQD-----TSPSRSTHNESNRLLATLRLLTVLSGHF 609
             |.:|   :...:..|...:|:      |.|.     ...|....:|...|.|||:.|:......
Mouse   673 TFFSR---VDFARSQLVDFLTD------RFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFYNAH 728

  Fly   610 NLSKWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKACFCCLCWDMENL-EGTALNNV--- 670
            :|::|:::||....|:..:....:|:...||.      |...:..:.|.:.:: |.|:...:
Mouse   729 DLTRWEISEPCSRLLRKAVDTGEVPHQVILPA------LTLVYFSILWTVTHISESTSHKQLMSL 787

  Fly   671 --DMDEYCDVLHHNLEDYLYVTFSLVGKSNTEP-LAYPCFSYTCDLFVLHG-NLCGSSNPSIRSV 731
              .|..:|::....|.|             .:| :....|....||.::.. .:.......:|.:
Mouse   788 KKRMVAFCELCQSCLSD-------------VDPEIQEQAFVLLSDLLLIFSPQMIVGGRDFLRPL 839

  Fly   732 AHVPSGNELDILEGFLMEHFLELSPSDL-MLETNSDQLQ-----RIRSILTSYLKVVCLGVVPTM 790
            ...|.......|..|||:|.. |.|.:| ..::..|.:|     :.|.:|..:.|::..||:...
Mouse   840 VFFPEATLQSELASFLMDHVF-LQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVLELD 903

  Fly   791 RASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVFPDDTRHAAGQRALR 855
            .||..:::|.|::..:||:::.::..|.|.:....:..:|.:...||.::..:.     |.:.|.
Mouse   904 AASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQ-----GPQGLT 963

  Fly   856 --PAEFSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEATKKLP---FLRV 915
              || |.|:.:||.|.|.......:.:|:.|:.||:.||  .|.|::..|..::.:.|   ||.:
Mouse   964 ELPA-FIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGI--KFSLSELPPAGSSHEPPNLAFLEL 1025

  Fly   916 LKVFVPLLLVQDKTRILNFFEPYEQLIIPTCNRNDIAHLKEYRNALRP 963
            |..|.|.|..|||..:|::.|...|.:....| :....:..|.::|.|
Mouse  1026 LSEFSPRLFHQDKRLLLSYLEKCLQRVSKAPN-HPWGPVTTYCHSLHP 1072

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	30/127 (24%)
Stag3	NP_058660.2	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..108		11/54 (20%)
		STAG	188..296	CDD:369917	25/108 (23%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1077..1154
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1213..1240
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167849834
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	8	7.810