DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and Stag3

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_446182.1	Gene:	Stag3 / 114522	RGDID:	621333	Length:	1256	Species:	Rattus norvegicus

Alignment Length:	1066	Identity:	250/1066 - (23%)
Similarity:	440/1066 - (41%)	Gaps:	216/1066 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly    12 NDSQASNQMDFE------IREECS--------IA--PNDEPVCVDGTVGDATNKSLLQMILSRKR 60
            :.|..|...|||      :|:..:        :|  |..:...|.|  |:..|||
  Rat    56 DSSSTSEDSDFEDSLRRNVRKRAAKRPPKAIPVAKHPKKQSHIVPG--GNDKNKS---------- 108

  Fly    61 LSPTN-------KRNSHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPDDTSMPFSYS 118
            :.||:       ...|..:|:...|.|.|.....|..:.|:.|.:...|....:..:.....|.|
  Rat   109 VPPTSDLFDAVKAARSCAQSLVDEWLENYKQDENAGFLELVNFFIRACGCKSTVTPEMFKTMSNS 173

  Fly   119 DILSNSSSHFS-NTHIYPLIRKPADVFVNQVGS---FLNALL------LVANKFRSDSYQLFLVQ 173
            :|:.:.:..|: ::..||| ..|...:....||   |:..|:      |:.:.|..|       .
  Rat   174 EIIQHLTEEFNEDSGDYPL-TAPGPSWKKFQGSFCEFVKTLVCQCQYSLLFDGFPMD-------D 230

  Fly   174 LTNFVMACSESNIRTFRHTATMIGLKIMTIL-------------------------------SDL 207
            |.:.::..|:|.:|.||||:|:..:|:||.|                               ..|
  Rat   231 LISLLIGLSDSQVRAFRHTSTLAAMKLMTSLVKVALQLSLHKDNNQRQYEAERNKGPEQRAPERL 295

  Fly   208 KSL---------DDEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFARYPHCHLQPTSL 263
            :||         :.|....:...:|..:||.|.|||:.:||.:||.|:|.|...|....|..:.|
  Rat   296 ESLLEKRKEFQENQEEIEGMMNAIFRGVFVHRYRDILPEIRAVCIEEIGCWMQSYSTSFLNDSYL 360

  Fly   264 RIFYEALNDGSGDV-IQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKEDAIAEKSVQF 327
            :.....|:|...:| ::| :..::.|.....|.|.:...|:.|::.:|.:.:.:|..:|.::::.
  Rat   361 KYIGWTLHDKHKEVRLKC-VKALAGLYSNQELSSRMELFTNRFKDRMVSMVMDRESEVAVEAIRL 424

  Fly   328 LTHFHVLSAEILTDDVCRVLEQLIMAANRGLAQAAADLFIL------------------RRNGLD 374
            ||........:||...|..:..::..:||.:|.:|.: |:.                  ||:...
  Rat   425 LTLILKNMEGVLTSADCEKIYSIVYISNRAMASSAGE-FVYWKIFHPECGAKAVSGRERRRSPQA 488

  Fly   375 GETFCQRVKHLLQLFIEC-GHEQADYLVDSLIDNC--ELVLDWKSMIAVLLENPKSRELSDIHCS 436
            ..||   :..||..|:|. .|:.|.||||||.| |  ..:.||:|:.::||:  |.:.|.|:...
  Rat   489 QRTF---IYLLLAFFMESEHHDHAAYLVDSLWD-CAGSYLKDWESLTSLLLQ--KDQNLGDMQER 547

  Fly   437 SLIAILLAGVKQATAGEIPPGRYT--KDL-KREPRQGAQERA--TKCLAPVLPELLRTYANRLQD 496
            .||.||::..:||..|..|.||.|  |.| .:|.:..|.::.  .:.|.|:||:||..::...::
  Rat   548 MLIEILVSSARQAAEGHPPVGRITGKKSLTAKERKLQAYDKVKLAEHLIPLLPQLLAKFSADAEN 612

  Fly   497 IERLLELPKYFCFDYYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLE----------- 550
            :..||.|..||..:.|..|       .|.:|.||:: .|.....|..:..:.||
  Rat   613 VAPLLRLLSYFDLNIYCTQ-------RLEKHLELLL-QQLQEVVVKHVEPEVLEAAAHALYLLCK 669

  Fly   551 ----FLNRMIPIPLTKQLLNSAVTNYKMAWHRTQD-----TSPSRSTHNESNRLLATLRLLTVLS 606
                |.:|   :...:..|...:|:      |.|.     ...|....:|...|.|||:.|:...
  Rat   670 PEFTFFSR---VDFARSQLVDLLTD------RFQQELDDLMQSSFLDEDEVYSLTATLKRLSAFY 725

  Fly   607 GHFNLSKWDLTEPLLFSLKMLLRQRRLPNGDDLPPEAFSLYLKACFCCLCWDMENL-EGTALNNV 670
            ...:|::|:::||....|:..:....:|:...||.      |...:..:.|.:.:: |.|:...:
  Rat   726 NAHDLTRWEISEPCSRLLRKAVDTGEVPHQVILPA------LTLVYFSILWTVTHISESTSQKQL 784

  Fly   671 -----DMDEYCDVLHHNLEDYLYVTFSLVGKSNTEP-LAYPCFSYTCDLFVLHG-NLCGSSNPSI 728
                 .|..:|::....|.|             .:| :....|....||.::.. .:.......:
  Rat   785 MSLKKRMVAFCELCQSCLSD-------------VDPEIQEQAFVLLSDLLLIFSPQMVVGGRDFL 836

  Fly   729 RSVAHVPSGNELDILEGFLMEHFLELSPSDL-MLETNSDQLQ-----RIRSILTSYLKVVCLGVV 787
            |.:...|.......|..|||:|.. |.|.:| ..::..|.:|     :.|.:|..:.|::..||:
  Rat   837 RPLVFFPEATLQSELASFLMDHVF-LQPGELGNGQSQEDHVQIELLHQRRRLLAGFCKLLLYGVL 900

  Fly   788 PTMRASKFYEYYVKYHAPFGDVMRCSMELALQRNPIHFAMTMLHTCLLLYAKVF----PDDTRHA 848
            ....||..:::|.|::..:||:::.::..|.|.:....:..:|.:...||.::.    |.|....
  Rat   901 ELDAASDVFKHYNKFYEDYGDIIKETLTRARQIDRCQCSRILLLSLKQLYTELIQEQGPQDLTEL 965

  Fly   849 AGQRALRPAEFSELMELANRLAKILISNPMEHRECVIALHRSGILFVFELAQKQPTEATKKLP-- 911
                   || |.|:.:||.|.|.......:.:|:.|:.||:.||  .|.|::..|..::::.|
  Rat   966 -------PA-FIEMRDLARRFALSFGPQQLHNRDLVVMLHKEGI--KFSLSELPPAGSSREPPNI 1020

  Fly   912 -FLRVLKVFVPLLLVQDKTRILNFFE 936
             ||.:|..|.|.|..|||..:|::.|
  Rat  1021 AFLELLSEFSPRLFHQDKQLLLSYLE 1046

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	28/131 (21%)
Stag3	NP_446182.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..110		14/65 (22%)
		STAG	188..296	CDD:400698	24/115 (21%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1096..1169
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1230..1256
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166353510
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E1_COG5537
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	8	7.860