DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment SA-2 and stag1

DIOPT Version :9

Sequence 1:	NP_612109.3	Gene:	SA-2 / 38167	FlyBaseID:	FBgn0043865	Length:	973	Species:	Drosophila melanogaster
Sequence 2:	NP_001121432.1	Gene:	stag1 / 100158523	XenbaseID:	XB-GENE-1006155	Length:	1265	Species:	Xenopus tropicalis

Alignment Length:	999	Identity:	237/999 - (23%)
Similarity:	434/999 - (43%)	Gaps:	148/999 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    69 SHIESVAKYWGEFYLDSPTAALVALLQFVVEVSGSHYQIPDDTSMPFSYSDILSNSSSHF-SNTH 132
            |.::||...|.|.|......||:.|:.|.::.||....:..:.......::|:...:..| .::.
Frog   103 SAMQSVVDDWIESYKQDRDIALLDLINFFIQCSGCKGTVRIEMFRNMQNAEIIRKMTEEFDEDSG 167

  Fly   133 IYPLI------RKPADVFVNQVGSFLNALL------LVANKFRSDSYQLFLVQLTNFVMACSESN 185
            .|||.      :|    |......|::.|:      ::.:::..|:       :.:.:...|:|.
Frog   168 DYPLTMPGPHWKK----FRCNFCEFISVLIRQCQYSIIYDEYMMDT-------VISLLTGLSDSQ 221

  Fly   186 IRTFRHTATMIGLKIMTIL-----------------------------------------SDLKS 209
            :|.||||:|:..:|:||.|                                         .:|:.
Frog   222 VRAFRHTSTLAAMKLMTALVNVALNLSIHQDNTQRQYEAERNKMIGKRANERLELLLQKRKELQE 286

  Fly   210 LDDEIAMTVWMQMFNSMFVARSRDIVTDIRLLCISELGQWFARYPHCHLQPTSLRIFYEALNDGS 274
            ..|||. .:...:|..:||.|.||.:.:||.:||.|:|.|...|....|..:.|:.....|:|..
Frog   287 NQDEIE-NMMNSIFKGIFVHRYRDAIAEIRAICIEEIGVWMKMYSDAFLNDSYLKYVGWTLHDRQ 350

  Fly   275 GDV-IQCSLDNISVLCRKDVLFSEIVALTSEFREILVELCLGKEDAIAEKSVQFLTHFHVLSAEI 338
            |:| ::| |..:..|.....||.::...|:.|::.:|.:.|.||..:|.::::.:|.....|.|.
Frog   351 GEVRLKC-LKALQSLYTNRELFPKLELFTNRFKDRIVSMTLDKEYDVAVEAIRLVTLILHGSEEA 414

  Fly   339 LTDDVCRVLEQLIMAANRGLAQAAADL----FILRRNGLDGETFCQR----------VKHLLQLF 389
            |:::.|..:..|:.:|:|.:|.||.:.    ...|.:....|...:|          ||.|:..|
Frog   415 LSNEDCENVYHLVYSAHRPVAVAAGEFLHKKLFSRHDPQAEEALAKRRGRSSPNGNLVKMLVLFF 479

  Fly   390 IECG-HEQADYLVDSLIDNC-ELVLDWKSMIAVLLENPKSRE--LSDIHCSSLIAILLAGVKQAT 450
            :|.. ||.|.||||||.::. ||:.||:.|..:|:|.|...|  :|:...|:||.:::..::||.
Frog   480 LESELHEHAAYLVDSLWESSQELLKDWECMTELLVEEPMQGEEVMSERQESALIELMVCTIRQAA 544

  Fly   451 AGEIPPGRYT-----KDLKREPRQGAQERATKCLAPVLPELLRTYANRLQDIERLLELPKYFCFD 510
            ....|.||.|     ...:|:.:...:.:.|:.....||.||..|:...:.:..||::|:||..:
Frog   545 EAHPPVGRGTGKRVLTAKERKTQLDDKNKLTEHFIVALPVLLSKYSADAEKVANLLQIPQYFDLE 609

  Fly   511 YYHEQNRMGQLNELVEHFELIIFDQTSSTTVLQITVKTLEFL--------NRMIPIPLTKQLLNS 567
            .|........|:.|::....:: ::...:.||:...||...|        || :.| ...||::.
Frog   610 LYSTGRMEKHLDSLLKQIRFVV-EKHIESDVLEACSKTYSILCSEEYTIQNR-VEI-AHSQLIDE 671

  Fly   568 AVTNYKMAWHRTQD--TSPSRSTHNESNRLLATLRLLTVLSGHFNLSKWDLTEPLLFSLKMLLRQ 630
            ....:.   |..::  .....:..:|...::|:|:.||......:|:||:    |..|...|||.
Frog   672 LADRFS---HAVEELLQEAEEADEDEIYNVMASLKRLTCFHNAHDLTKWE----LFVSCYRLLRA 729

  Fly   631 RRLPNGDDLPPEAFSLYLKACFC---CLCWDMENL-EGTALNNVDMDEYCDVLHHNLEDYLYVTF 691
                 |.:.......:.::|..|   .:.|.:..: ||    |...:|.. .|...::.:|.|..
Frog   730 -----GIEHEGMMEQIVVQALQCSHYSILWQLVKITEG----NPSKEEML-TLRKTVKTFLAVCQ 784

  Fly   692 SLVGKSNTEPLAYPCFSYTCDLFVL--HGNLCGSSNPSIRSVAHVPSGNELDILEGFLMEH-FLE 753
            ..: .|.|..:....|...|||.::  |....|.....:..|.:...|.:.::| .|:|:| |::
Frog   785 QYL-SSVTTTVKEQAFMLLCDLLMIFSHQLTTGGRENLVLLVFNPDVGLQSELL-NFVMDHVFID 847

  Fly   754 LSPSDLMLETNSDQ-------LQRIRSILTSYLKVVCLGVVPTMRASKFYEYYVKYHAPFGDVMR 811
            ....:..:|.:.:.       |.:.|::|.::.|::...:|....|:..:::|:||:..:||:::
Frog   848 QDDENQSMEGDEEDEANKIEALHKRRNLLAAFCKLIIYDIVDMHAAADIFKHYMKYYNDYGDIIK 912

  Fly   812 CSMELALQRNPIHFAMTMLHTCLLLYAKVFPDDTRHAAGQRALRPAEFSELMELANRLAKILISN 876
            .::....|.:.|..|.|:    :|...::|.:..:..........|..|.:.|||.|.|.....:
Frog   913 ETLSKTRQMDKIQCAKTL----ILSLQQLFNELVQEQGPNLDRTSAHVSGIKELARRFALTFGLD 973

  Fly   877 PMEHRECVIALHRSGILFVFELAQKQPTE-ATKKLPFLRVLKVFVPLLLVQDKTRILNFFEPY-- 938
            .::.||.|..||:.||.|.|:....:..| ....|.||.||..|...||.|||..:.::.|.:
Frog   974 QIKTREAVATLHKDGIEFAFKYQNPKGQEYPPLNLAFLEVLSEFSSKLLRQDKKTVHSYLEKFLT 1038

  Fly   939 EQLIIPTCNRNDI-AHLKEYRNAL 961
            :|::.   .|.|: ..|..|||:|
Frog  1039 DQMME---RREDVWLPLISYRNSL 1059

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
SA-2	NP_612109.3	STAG	134..217	CDD:285686	24/135 (18%)
stag1	NP_001121432.1	STAG	167..275	CDD:285686	20/118 (17%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	1	1.010	-	-		QHG60131
OrthoDB	1	1.010	-	-		D167826at2759
OrthoFinder	1	1.000	-	-		FOG0000572
OrthoInspector	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR11199
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	6	6.030