DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG9168 and R03G8.1

DIOPT Version :9

Sequence 1:	NP_612106.2	Gene:	CG9168 / 38163	FlyBaseID:	FBgn0035216	Length:	648	Species:	Drosophila melanogaster
Sequence 2:	NP_510172.2	Gene:	R03G8.1 / 187544	WormBaseID:	WBGene00010996	Length:	663	Species:	Caenorhabditis elegans

Alignment Length:	693	Identity:	154/693 - (22%)
Similarity:	274/693 - (39%)	Gaps:	117/693 - (16%)

- Green bases have known domain annotations that are detailed below.

  Fly     7 VFLLCSIQFLLCKAKLSLHSHYPNVAKTLENKKFYVDSPSCKMPEMDPFSADIMRFFKRRQ--FR 69
            :::|..|.|.. ...:.:|:.|  .|...|:........:|::|..|.:..::..:....:  .:
Worm    18 LYILVCIAFTY-SVSIVIHTDY--AAPVTEDILVGNSWDTCELPRYDVWDEELFGYLNPNENPLK 79

  Fly    70 EC-SSDKDLLISEFDSHLRQYRIKIDENSAQQHLKKFG-----NATLKCEYQVIGRNKKDSFPDN 128
            :| :|.|.|             .|: |||      |:|     |.|.:.......|:|::...:.
Worm    80 KCDTSFKPL-------------TKL-ENS------KWGVTFAHNLTCRARCHTRKRDKENLVGNW 124

  Fly   129 HFSFSKLQPLSQSFLVPKTIDFISTQCHAVHGNIDLKLLQKDAFLFVQDRLNHEHKNTEHHRPDL 193
            .::..|:           ..:.:.|.|....|.      |:|.:.::..::............||
Worm   125 TYTPGKI-----------NCEILETVCAEKGGE------QRDVYGYLHSQIIPTKPKLSRTNADL 172

  Fly   194 QSKPNVIILGIDSTSRMNLRRSMPKVHKFLQRPGWFEMQG-----YNKVGENTLPNLLAILTGNA 253
            : :.:|.::.:||.|.....||:|:...|.:.    .|:|     .||||:|:.||.:|:..|..
Worm   173 K-EYDVFVILLDSLSYSQAARSLPRTVSFFKS----YMKGIIFPYMNKVGDNSRPNGVALWFGKL 232

  Fly   254 EE------------NALFNGRFGHSGFIDKLKFIWQLFKKNGYMTAFGEDCAKINTFNYQK-PGF 305
            .|            .|.:...:..:.|.|....::..||.:||.|...||.| :.|..:.. .|:
Worm   233 LEKVDRFIFDKPSLEADWTDDYFCNVFKDNETSLFDEFKTHGYKTLMAEDWA-LGTLIWPNCLGY 296

  Fly   306 KQQPVDFYLRNFIVALET--ILKTRREFGNVFCLGRKLGFQYVFDFARQFMQRFENS-------- 360
            :.|.:|.|:|.|.:|.|.  ...||.......|   :.....:.|:..||:..:..|
Worm   297 RNQSIDHYMRPFQLAHEKYGTPVTREHLNGSLC---REDHNTLLDYLAQFLDAYSGSNDSIQLKR 358

  Fly   361 -----AP---VFGIFWSNSFTH--EDFLGAT--ALDHVFLEYLTLYDELGFFNRSIVMVLSDHGY 413
                 :|   .|...|:....|  |:...||  ..|:.||.:...:.:.  ...|.|::|.|||:
Worm   359 EKSPNSPDQRKFAFLWTTRLGHATENGFDATENGSDNDFLNFFIKHRKK--LEDSFVLLLGDHGF 421

  Fly   414 RYGVTRQASKSGYLEERLPLMFIHVPPWFRKIYPQYVENLKINQNRLSSGFDLHMTLHHLLHLNA 478
            |.|..|..: .|.::...||..|.||...| .....::.|.:|..:|.:.||...|:..:|....
Worm   422 RLGGVRNTA-VGAIDVNNPLTAISVPNSLR-TNTDILKILNMNSEKLQTHFDTRATILDILKFQP 484

  Fly   479 TSMADFSPKLQASQCKMCQSLFFQLPANRNCSHAGIREKWCSCE--PTETVTNQRLLRKVAQEVV 541
            .........||....|....|..|.|.||||....|..::|.|:  .|....|..:..::.::|.
Worm   485 AEKFSAITPLQIPGEKGQSHLRNQPPFNRNCQTMPIPFEYCICQFNKTSVPINSTISMEIGEKVA 549

  Fly   542 HHMNRHLRDRNLTTLCQNYALKK---VLYLDSKISLSEDSVEDEQLHTYIITFETNPSSAHFEAT 603
            .::|:.|:..|.|:.|.:...::   :|..:.|:.       :..::|.|...: .||.|.|:||
Worm   550 ENVNKLLQINNFTSECISMVFERTESLLQYNQKLG-------NSTIYTVIAQMK-KPSEAKFKAT 606

  Fly   604 VQWNSEKETLNMNVDELSRLESYEKHSKCTRDPIIKKYCICKE 646
            |:.......:   |.::.|::||.|.:.|......:..|.|||
Worm   607 VKITEGNIKI---VSKVERVDSYGKTADCIESETHRPICYCKE 646

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG9168	NP_612106.2	DUF229	64..566	CDD:308570	123/554 (22%)
R03G8.1	NP_510172.2	DUF229	74..651	CDD:281053	144/634 (23%)
R03G8.1	NP_510172.2	ALP_like	175..483	CDD:293745	80/319 (25%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C160165337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	1	1.100	-	-	O	PTHR10974
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	3	2.940