DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and PTPN9

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_002824.1	Gene:	PTPN9 / 5780	HGNCID:	9661	Length:	593	Species:	Homo sapiens

Alignment Length:	281	Identity:	104/281 - (37%)
Similarity:	153/281 - (54%)	Gaps:	22/281 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQL 94
            |:|. |...||.....|..|.|..:..:  |||.||...|.:|:.|.:.|    .|||||:.:..
Human   304 YEEY-EDIRRENPVGTFHCSMSPGNLEK--NRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDG 365

  Fly    95 ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPH 159
            .:.:..||.|||||.:|...|||||||||...::|..:..|..:.||..|||.|    |..::..
Human   366 YKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE----KDSRIRF 426

  Fly   160 VKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSG 224
            ..|||..:.:|...::.:...::.:.|.:|.|:|..|.:.:|||:|:|||..:.:.||:.||:..
Human   427 GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRNQQ 491

  Fly   225 CL------SRDVG-----PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMG 278
            .|      :|..|     |.||||||||||:||||.:|.||..:::.|..||.:.:..:|:.|..
Human   492 SLAVSNMGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAF 556

  Fly   279 LIQTADQLDFSYQAIIEGIKK 299
            .|||.:|..|.|:||:|..:|
Human   557 SIQTPEQYYFCYKAILEFAEK 577

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	102/275 (37%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	94/247 (38%)
PTPN9	NP_002824.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		CRAL_TRIO_N	20..68	CDD:215024
		SEC14	90..240	CDD:214706
		PTPc-N9	299..569	CDD:350391	99/271 (37%)
		Substrate binding. /evidence=ECO:0000250	515..521		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	2	1.910