DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and PTPN2

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_005258181.1	Gene:	PTPN2 / 5771	HGNCID:	9650	Length:	438	Species:	Homo sapiens

Alignment Length:	557	Identity:	188/557 - (33%)
Similarity:	254/557 - (45%)	Gaps:	171/557 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEAEYKDKGPQ--WHRFYKEI-CETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK 80
            ||.|:::...|  |...|.|| .|:.|...:..:|.       .||..||||||:||||||:.|:
Human     5 IEREFEELDTQRRWQPLYLEIRNESHDYPHRVAKFP-------ENRNRNRYRDVSPYDHSRVKLQ 62

  Fly    81 RGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYW 145
            ....|||||:||.:|.|:|.||||||||.:|..|||||||:||::||:|||:::||:.:||..||
Human    63 NAENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRIVEKESVKCAQYW 127

  Fly   146 P--------NEMGADKALKLPHVK--LTVELVRLETYQNFVRRWFKL----------TDLETQQS 190
            |        .|.|....|....||  .||.|::||........|..|          ..|::.::
Human   128 PTDDQEMLFKETGFSVKLLSEDVKSYYTVHLLQLENINYIENLWITLYLKLLMLDVKRSLKSGET 192

  Fly   191 REVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLV 255
            |.:..||||||||||:|.||.:||.||.:||:||.|:.|.||||:||||||||||||.|||.|||
Human   193 RTISHFHYTTWPDFGVPESPASFLNFLFKVRESGSLNPDHGPAVIHCSAGIGRSGTFSLVDTCLV 257

  Fly   256 LIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETH 320
            |::|..:.|:.:||..:|.||||||||.|||.|||.|||||.|             .|..|:
Human   258 LMEKGDDINIKQVLLNMRKYRMGLIQTPDQLRFSYMAIIEGAK-------------CIKGDS--- 306

  Fly   321 TLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDA 385
                                        |:..|          .|||||:
Human   307 ----------------------------SIQKR----------WKELSKE--------------- 318

  Fly   386 EVADSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHAD 450
                                                           |..|...|.|  .:...:
Human   319 -----------------------------------------------DLSPAFDHSP--NKIMTE 334

  Fly   451 DVNANNEKPAVPVDEQ----HKANGI-DPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQ 510
            ..|.|.    :.::|:    .:..|: ..:...:..:.|:.|::|.|.:.:|:..|||..||::.
Human   335 KYNGNR----IGLEEEKLTGDRCTGLSSKMQDTMEENSESALRKRIREDRKATTAQKVQQMKQRL 395

  Fly   511 RENEDKQLAAKKR----------RSLLTYIAAGVVVG 537
            .|||.|    :||          ...::.|..|..||
Human   396 NENERK----RKRWLYWQPILTKMGFMSVILVGAFVG 428

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	142/281 (51%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	134/252 (53%)
PTPN2	XP_005258181.1	PTP_DSP_cys	19..295	CDD:391942	140/282 (50%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165160026
Domainoid	1	1.000	277	1.000	Domainoid score	I1738
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7497
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2713
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm40257
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	O	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	15	14.830