DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and PTPN1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_002818.1	Gene:	PTPN1 / 5770	HGNCID:	9642	Length:	435	Species:	Homo sapiens

Alignment Length:	477	Identity:	180/477 - (37%)
Similarity:	252/477 - (52%)	Gaps:	86/477 - (18%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQIEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL 79
            :::|.|::  ||...|...|::|    ..||.:.....::..::.||  ||||||:|:|||||.|
Human     1 MEMEKEFEQIDKSGSWAAIYQDI----RHEASDFPCRVAKLPKNKNR--NRYRDVSPFDHSRIKL 59

  Fly    80 KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY 144
            .:...|||||:|:::|.|:|.||||||||.:|.||||.||||||||.|:|||::|||..:||..|
Human    60 HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRVMEKGSLKCAQY 124

  Fly   145 WPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSS 209
            ||.:...:...:..::|||:....:::|  :..|..:|.:|.||::||::.||||||||||:|.|
Human   125 WPQKEEKEMIFEDTNLKLTLISEDIKSY--YTVRQLELENLTTQETREILHFHYTTWPDFGVPES 187

  Fly   210 PNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCE 271
            |.:||.||.:||:||.||.:.||.||||||||||||||||.|.||:|:||.   ...::.|||.|
Human   188 PASFLNFLFKVRESGSLSPEHGPVVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLE 252

  Fly   272 LRSYRMGLIQTADQLDFSYQAIIEGIK-KLHDPTFLDAEEPLISNDTETHTLDELPPPLPP-RVQ 334
            :|.:|||||||||||.|||.|:|||.| .:.|.:..|..:.|...|.|.......|||.|| |:
Human   253 MRKFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHEDLEPPPEHIPPPPRPPKRI- 316

  Fly   335 SLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVR 399
                 |.|::|                         ....|...|..:
Human   317 -----LEPHNG-------------------------KCREFFPNHQWV----------------- 334

  Fly   400 AFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVD 464
                             :::|.||::. .|.|....|:|. .|...:..:.|....:.   |...
Human   335 -----------------KEETQEDKDC-PIKEEKGSPLNA-APYGIESMSQDTEVRSR---VVGG 377

  Fly   465 EQHKANGIDPIPGQLPASPENE 486
            ....|....|..|: |:.||.:
Human   378 SLRGAQAASPAKGE-PSLPEKD 398

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	139/263 (53%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	133/235 (57%)
PTPN1	NP_002818.1	PTPc	3..276	CDD:214550	144/280 (51%)
		Substrate binding. /evidence=ECO:0000250	215..221		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	338..359		7/22 (32%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	378..398		6/20 (30%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	277	1.000	Domainoid score	I1738
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	299	1.000	Inparanoid score	I2713
Isobase	1	0.950	-	0	Normalized mean entropy	S2559
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm40257
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	LDO	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	13	12.850