Protein Alignment Ptp61F and ptpn22

DIOPT Version :10

• Sequence 1: NP_476687.1
• Gene: Ptp61F / 38160
• FlyBaseID: FBgn0267487
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: NP_001092890.2
• Gene: ptpn22 / 565606
• ZFINID: ZDB-GENE-060503-458
• Length: 901
• Species: Danio rerio
• Alignment Length: 661
• Identity: 144/661 - (21%)
• Similarity: 245/661 - (37%)
• Gaps: 225/661 - (34%)

  Fly    47 EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGP 107
            |:.:.|:.:::..|...|||:|:.|:||||:.|    .:...|||||:.::.....:.||.||||
Zfish    46 ERTYPTTAADKQDNVKKNRYKDIVPFDHSRVKLSLFTSKNDTDYINASFIKGVSGSKAYIATQGP 110

  Fly   108 LVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETY 172
            |.:||..||.|:||...:.::|:.:..|..:.||..|||...|.....:    ..|:.....|..
Zfish   111 LSNTVLDFWRMIWEYNIKVIVMVCREFEMGRKKCERYWPESKGDVFVCE----AFTILYESDENK 171

  Fly   173 QNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVR---DSGCLSRDVGPAV 234
            .:::.|..|:|  ..|:||.:.|.||..|||.|:|.|..|.|:.||::|   |:     :..|..
Zfish   172 GDYLTRTLKVT--FKQESRRLKQLHYVNWPDHGVPDSIPAILELLQEMRIYQDN-----EEIPIC 229

  Fly   235 VHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEG 296
            :|||||.||:|..|.:|....|:.:.   .:.::.:::..:|:.|..::||.:|    |:.:...
Zfish   230 IHCSAGCGRTGALCAIDYTWNLLKRQIIPEDFSIFELVKGMRTQRPSVVQTKEQ----YELVYRT 290

  Fly   297 IKKLHDPTFLDAEEP-----------LISNDTE-------------THTLDEL------------ 325
            ||.|.:......|.|           ::|:.:|             .|..||:
Zfish   291 IKLLFERYLAALEAPSNKVPDSSSPAMLSSGSELSDISDFSDQEQTEHRNDEIRVDEYNHVMQNS 355

  Fly   326 -------PPPLPPRVQSLNLP--------------------LAP---------------NSGGIL 348
                   ..|..|.|.|..|.                    :||               .|..:.
Zfish   356 ASWQQPHSQPFSPEVMSNKLTPADLHNARCEWVQITDQSSFIAPVLQTDFTTCGSQKPDASTSLS 420

  Fly   349 SLNMRAAQANGAESIGKEL--SKDALNNFINQ--------HDMI--------------------- 382
            :.:.:.:.:|...|..:||  :|:.|....||        |:.:
Zfish   421 TTSTQVSCSNYPISFVEELKPNKEHLEWVENQEASPVVKDHNTVIPSTLCLTVEDPYFGPESPPG 485

  Fly   383 -------------------------------------HDAE-------VADSRPLPPLPVRAFND 403
                                                 ||:.       .:|....||||.|
Zfish   486 SNNPSVLNCTAHEIWTEKSCFTIPSLALNNQALEMPKHDSNNKGGNTLSSDEESPPPLPER---- 546

  Fly   404 SDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQHK 468
              :.|.:::.|:....:: :|:.||     ::.:...:|.:|.  ::.||.:|....||
Zfish   547 --TPESFIMADETSGQSN-NEKSET-----SELLTLVIPTSTS--SESVNRDNPPSPVP------ 595

  Fly   469 ANGIDPIPGQLPAS-----------------PENELKR-RKRNEYQASLEQKVNDMKRKQRENED 515
                 |:|.:.|.|                 |:..:.| .|..|:.....:...||||....::
Zfish   596 -----PLPERTPESFEMAMDADLVQNVTQEKPQEVVMRVGKSLEWSGQTNEGQTDMKRSWSRSK- 654

  Fly   516 KQLAAKKRRSL 526
               :.|.|.||
Zfish   655 ---SLKLRMSL 662

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc-N1_2	63..291	CDD:350393	77/237 (32%)
ptpn22	NP_001092890.2	None