DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptp69D

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_524048.2	Gene:	Ptp69D / 39443	FlyBaseID:	FBgn0014007	Length:	1462	Species:	Drosophila melanogaster

Alignment Length:	455	Identity:	131/455 - (28%)
Similarity:	206/455 - (45%)	Gaps:	81/455 - (17%)

- Green bases have known domain annotations that are detailed below.

  Fly     6 TSGSGSAAAA----RLQIEAEYKDKGPQWHR-----FYKEICETCDREAKEKQFS---TSESERH 58
            |||:.....|    ||.:|..||::    |:     |.:|.      |....:||   |..|:..
  Fly   861 TSGNHKGFDAGPIHRLDLENAYKNR----HKDTDYGFLREY------EMLPNRFSDRTTKNSDLK 915

  Fly    59 TNRGLNRYRDVNPYDHSRIVLK--RG--SVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMV 119
            .|...|||.|:..||.:|:.|.  .|  :.||||||.|...:..:::|..|||:..|:..||.|:
  Fly   916 ENACKNRYPDIKAYDQTRVKLAVINGLQTTDYINANFVIGYKERKKFICAQGPMESTIDDFWRMI 980

  Fly   120 WEQKSRAVLMLNKLMEKKQIKCHLYWPNEM-----GADKALKLPHVKLTVELVR--LETYQNFVR 177
            |||....::||..|.|..:.||..|||.::     ..|..:|....:.|.:.:.  |...:|
  Fly   981 WEQHLEIIVMLTNLEEYNKAKCAKYWPEKVFDTKQFGDILVKFAQERKTGDYIERTLNVSKN--- 1042

  Fly   178 RWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIG 242
               |....|.:..|::.|:||.||.||..|..|:..:||::|:.....|.|  ||.:||||||:|
  Fly  1043 ---KANVGEEEDRRQITQYHYLTWKDFMAPEHPHGIIKFIRQINSVYSLQR--GPILVHCSAGVG 1102

  Fly   243 RSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLD 307
            |:||...:|..:..:::....::...:|:||..|..|:|:..|..|.|:|:::      ..||.:
  Fly  1103 RTGTLVALDSLIQQLEEEDSVSIYNTVCDLRHQRNFLVQSLKQYIFLYRALLD------TGTFGN 1161

  Fly   308 AEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNSGGI-LSLNMRAAQANGAESIGKELS--K 369
            .:   |..||....::             :|...||.|.. |.:......|. |:.|.|..|  :
  Fly  1162 TD---ICIDTMASAIE-------------SLKRKPNEGKCKLEVEFEKLLAT-ADEISKSCSVGE 1209

  Fly   370 DALNNFINQHDMI--HDAEVADSRPLPPLPVRA----FNDS-----DSDEDYLLDDDDEDDTDED 423
            :..||..|:...|  :|   .:...|.|||:|.    .|.|     |:.|.:::..|..::|..|
  Fly  1210 NEENNMKNRSQEIIPYD---RNRVILTPLPMRENSTYINASFIEGYDNSETFIIAQDPLENTIGD 1271

Fly 424 423
Fly 1272 1271

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	88/274 (32%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	81/243 (33%)
Ptp69D	NP_524048.2	IG_like	139..233	CDD:214653
		Ig	150..221	CDD:143165
		fn3	237..321	CDD:278470
		FN3	339..432	CDD:238020
		FN3	439..535	CDD:238020
		PTPc	892..1155	CDD:214550	89/276 (32%)
		PTPc	920..1155	CDD:238006	81/242 (33%)
		PHA02694	<1121..1206	CDD:177476	24/107 (22%)
		PTPc	1186..1449	CDD:214550	23/90 (26%)
		PTPc	1216..1449	CDD:238006	15/59 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443552
Domainoid	1	1.000	133	1.000	Domainoid score	I1104
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	4	3.840