DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and ptpn2a

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_956760.2	Gene:	ptpn2a / 393438	ZFINID:	ZDB-GENE-040426-1196	Length:	392	Species:	Danio rerio

Alignment Length:	539	Identity:	176/539 - (32%)
Similarity:	252/539 - (46%)	Gaps:	163/539 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR 81
            ::.|:|  |...:|...|.|:    ..:::|:.:..::...:.||  ||||||:||||||:.|:.
Zfish     1 MDQEFKNIDSSGEWQNLYNEL----HNQSQERSYKVAKFPENCNR--NRYRDVSPYDHSRVKLEN 59

  Fly    82 GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP 146
            ...|||||:|:.:|.|:|:||||||||.:|.||||||||||.|:||:|||:::||...||..|||
Zfish    60 SENDYINASLITMEEAQRRYILTQGPLKNTCGHFWLMVWEQGSKAVIMLNRVIEKGTEKCAQYWP 124

  Fly   147 NEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPN 211
            ::...|  :........|.||..:...|:..|..:|.:.:|.::|::..||||.|||||:|.||.
Zfish   125 SKEEQD--MNFSDTGFMVTLVCEDVKPNYTIRLLELQNGKTGETRDIYHFHYTAWPDFGVPESPA 187

  Fly   212 AFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE---CNVSKVLCELR 273
            :||.||.:||:||.|..:.||.||||||||||||:|.|||.||||:|:..:   .::.|||.::|
Zfish   188 SFLDFLFKVRESGSLGPENGPVVVHCSAGIGRSGSFSLVDTCLVLMDQRNDFLAVDIQKVLLDMR 252

  Fly   274 SYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLNL 338
            .||||||||.|||.|||.|::||.|             ||..|:   ||
Zfish   253 EYRMGLIQTPDQLRFSYMAVMEGAK-------------LILGDS---TL---------------- 285

  Fly   339 PLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFND 403
                 ...|||                      ..|:|.:.|.:
Zfish   286 -----QSSILS----------------------PENYIGESDRM--------------------- 302

  Fly   404 SDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQHK 468
                        :..|:..::|::..                                |.:|
Zfish   303 ------------EPQDSGLEQEWKRF--------------------------------PKEE--- 320

  Fly   469 ANGIDPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQLAAKKR------RSLL 527
                     ||.......|::|.|.|..|:..|:|..||.|..::|      |||      |.:|
Zfish   321 ---------QLSELKTFSLRKRSRKERIANTAQQVQKMKMKLSDSE------KKRENWLFWRPIL 370

  Fly   528 TYIAAGVVV--GVICAYAY 544
            ..:.||..|  |:...:|:
Zfish   371 LNVGAGAAVAFGLCICWAF 389

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	131/263 (50%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	126/235 (54%)
ptpn2a	NP_956760.2	PTPc	11..274	CDD:214550	132/270 (49%)
ptpn2a	NP_956760.2	PTPc	41..274	CDD:238006	127/236 (54%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C170596322
Domainoid	1	1.000	269	1.000	Domainoid score	I1802
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm25111
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	O	PTHR46047
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.800