DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and IA-2

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_608562.4	Gene:	IA-2 / 33277	FlyBaseID:	FBgn0031294	Length:	1319	Species:	Drosophila melanogaster

Alignment Length:	396	Identity:	121/396 - (30%)
Similarity:	182/396 - (45%)	Gaps:	60/396 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEAEYKDKG---PQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK 80
            :|...::||   .:|....:...|...|||         :.:....||||.....||||||:||.
  Fly   950 MEDHLRNKGRLQREWEALCRYEAEPSAREA---------ASQPQCAGLNRPGAPLPYDHSRVVLN 1005

  Fly    81 R----GSVDYINAN-LVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIK 140
            .    ..:||:||: :...:.....|:..||||..|:.|||.|:|||.:..::.|.:|.|..::.
  Fly  1006 HLANAEGLDYVNASTITDHDPRAPAYVAAQGPLPSTLAHFWQMIWEQGAVVIVALCRLQENGEVA 1070

  Fly   141 CHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFG 205
            |..|||.| ||: ...:..|.|..|.:..:.|   :.|.|.|.:|.|.::|.|.|||:.:||..|
  Fly  1071 CARYWPEE-GAE-VYHIYEVHLVSEHIWCDDY---LVRSFYLKNLRTSETRTVTQFHFLSWPHMG 1130

  Fly   206 IPSSPNAFLKFLQQVRDS-----GCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYG-ECN 264
            :|:...|.|.|.::|..|     .|      |.|||.|||.||:|.:.|:|..|..::|.. |.:
  Fly  1131 VPAQAKALLDFRRKVNKSYRGRRSC------PIVVHGSAGAGRTGVYILLDLVLERMNKGAREID 1189

  Fly   265 VSKVLCELRSYRMGLIQTADQLDFSYQAIIEGI----KKLHDPTF-----LDAEEPLISNDTETH 320
            ::..|..||..|.|::.|..|.:|...|:.|.:    |.|...|.     || ::|::...:.:.
  Fly  1190 IAATLEHLRDQRAGVVATRQQFEFVLMAVAEEVHAILKALPANTSGEKRELD-KDPVVGGGSSST 1253

  Fly   321 TLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDA 385
            |..|  |....:.|......||.|      :.:||.|...|   ||..||.     .:......|
  Fly  1254 TTKE--PLKEDKAQEAAEEEAPTS------SSKAAAAAKKE---KEKDKDK-----EEKQAKDQA 1302

  Fly   386 EVADSR 391
            :||:.|
  Fly  1303 KVAEPR 1308

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	91/271 (34%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	87/243 (36%)
IA-2	NP_608562.4	Receptor_IA-2	708..795	CDD:288410
		PTPc	960..1220	CDD:214550	92/279 (33%)
		PTPc	995..1220	CDD:238006	83/235 (35%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45443528
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	1	1.000	-	-		otm46470
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	3	2.840