DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp61F and Ptpn18

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_038939136.1	Gene:	Ptpn18 / 301333	RGDID:	1311586	Length:	459	Species:	Rattus norvegicus

Alignment Length:	458	Identity:	128/458 - (27%)
Similarity:	188/458 - (41%)	Gaps:	109/458 - (23%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 STSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDT 111
            ||....:..|...|||:||.|||.:|::|    :.|..||||||.::.....:.||.|||||..|
  Rat    47 STKAGSQQGNSKKNRYKDVVPYDETRVILSLLQEEGHGDYINANFIRGTDGSQAYIATQGPLPHT 111

  Fly   112 VGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYW-----PNEMGADKALKLPHVKLTVELVRLET 171
            :..||.:|||...:.:||..:..|..:.||..||     |.:.|...........||.: :.|.|
  Rat   112 LLDFWRLVWEFGVKVILMACQETENGRRKCERYWAQEREPLQAGPFCITLTKETALTAD-ITLRT 175

  Fly   172 YQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCL-SRDVGPAVV 235
            .|    ..|:......::||.|.|..|.:|||.|:|||.:..|..:::.|   || ....||..|
  Rat   176 LQ----VTFQKVPKGQKESRPVHQLQYMSWPDHGVPSSSDHILTMVEEAR---CLQGLGPGPLCV 233

  Fly   236 HCSAGIGRSGTFCLVDCC-LVLIDKYGECNVS--KVLCELRSYRMGLIQTADQLDFSYQAIIEGI 297
            |||||.||:|..|.||.. .:|:.:....|.|  :|:.|:|..|...:||.:|..|.|..:.:..
  Rat   234 HCSAGCGRTGVLCAVDYVRQLLLTQTIPPNFSLFEVVLEMRKQRPAAVQTEEQYRFLYHTVAQLF 298

  Fly   298 KKL---HDPTFLDAEE---PLISNDTETHTLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQ 356
            .:.   :.|.:.:.:|   |:..:.:...|...||        :.:.||    ||:|
  Rat   299 SRTLQNNSPLYQNLKENRAPICKDSSSLRTSSALP--------ATSRPL----GGVL-------- 343

  Fly   357 ANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPP-LPVRAFNDSDSDEDYLLDDDDEDDT 420
                .||                          |.|.|| ||:.                   ||
  Rat   344 ----RSI--------------------------SVPGPPTLPMA-------------------DT 359

  Fly   421 DEDEEYETINEHDADPVNGHVPATTQPHADDVNANNE-KPAV--PVDEQHKANGIDPIPGQLPAS 482
                 |..:.:..|....|  |.|..|::.|....:: .|.:  ||.....|.|...: |::||.
  Rat   360 -----YAVVQKRGAPAGTG--PGTRAPNSTDTPIYSQVAPRIQRPVSHTENAQGTTAL-GRVPAD 416

  Fly   483 PEN 485
             ||
  Rat   417 -EN 418

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	90/256 (35%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	87/245 (36%)
Ptpn18	XP_038939136.1	PTP_DSP_cys	27..298	CDD:421693	90/258 (35%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810