DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and ptpn1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001300614.1	Gene:	ptpn1 / 30081	ZFINID:	ZDB-GENE-980605-23	Length:	433	Species:	Danio rerio

Alignment Length:	410	Identity:	172/410 - (41%)
Similarity:	238/410 - (58%)	Gaps:	48/410 - (11%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR 81
            :|||::  |:...|:..|:||      ..:........::...||..||||||:|:|||||.|:.
Zfish     1 MEAEFREIDEHGNWNDVYQEI------RQQSSDLPCKIAKLPENRSRNRYRDVSPFDHSRICLQI 59

  Fly    82 GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP 146
            |..|||||:|:.:|.|:|:||||||||.:|.||||.|||||:||.|:|||:::||..:||..|||
Zfish    60 GCNDYINASLISVEEAQRKYILTQGPLPNTCGHFWEMVWEQRSRGVVMLNRVIEKGSVKCAQYWP 124

  Fly   147 NEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPN 211
            .....:...:..:.:||:....:::|  :..|..:|.:|.||::||::.||||||||||:|.||.
Zfish   125 QREEREAVFEDTNFRLTLISEDVKSY--YTVRQLELENLSTQETREILHFHYTTWPDFGVPESPA 187

  Fly   212 AFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCELR 273
            :||.||.:||:|||||.::||.||||||||||||||||||.||:|:.:.   ....:.:||.|:|
Zfish   188 SFLNFLFKVRESGCLSPELGPVVVHCSAGIGRSGTFCLVDTCLLLMSQRKDPSSVRIQEVLLEMR 252

  Fly   274 SYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPL------PPR 332
            .||||||||||||.|||.|.|||.|.:...|.:......:||:      ::|||.|      |||
Zfish   253 RYRMGLIQTADQLRFSYLAFIEGAKYIMGDTSVQESWKELSNE------EDLPPELTPPPRPPPR 311

  Fly   333 VQSLNLPLAPNSGGILS------------LNMRAAQANGAESI---GKELSKDALNNFINQHDMI 382
            :.      .||..|.|.            .|.....||.|...   |.|:.|..:...:....::
Zfish   312 ID------PPNGKGDLGNSDLAHLFTESITNSAEICANSAPKTFTDGPEIRKRTVPAEVGALPLV 370

  Fly   383 HDA--EVADSRPLPPLPVRA 400
            ::.  |....|..||.|.|:
Zfish   371 NEQPDEPIIPREAPPKPPRS 390

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	136/263 (52%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	131/235 (56%)
ptpn1	NP_001300614.1	PTPc	1..274	CDD:214550	141/280 (50%)
ptpn1	NP_001300614.1	PTPc	41..274	CDD:238006	131/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	269	1.000	Domainoid score	I1802
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	289	1.000	Inparanoid score	I2798
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm25111
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	LDO	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
ZFIN	0	0.000	Not matched by this tool.
	12	11.900