DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn9

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001013058.1	Gene:	Ptpn9 / 266611	RGDID:	628726	Length:	593	Species:	Rattus norvegicus

Alignment Length:	277	Identity:	104/277 - (37%)
Similarity:	151/277 - (54%)	Gaps:	22/277 - (7%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKRGS----VDYINANLVQL 94
            |:|. |...||.....|..|.|..:..:  |||.||...|.:|:.|.:.|    .|||||:.:..
  Rat   304 YEEY-EDIRRENPVGTFHCSMSPGNLEK--NRYGDVPCLDQTRVKLTKRSGHTQTDYINASFMDG 365

  Fly    95 ERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPH 159
            .:.:..||.|||||.:|...|||||||||...::|..:..|..:.||..|||.|    |..::..
  Rat   366 YKQKNAYIGTQGPLENTYRDFWLMVWEQKVLVIVMTTRFEEGGRRKCGQYWPLE----KDSRIQF 426

  Fly   160 VKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDS- 223
            ..|||..:.:|...::.:...::.:.|.:|.|:|..|.:.:|||:|:|||..:.:.||:.||..
  Rat   427 GFLTVTNLGVENMNHYKKTTLEIHNTEERQKRQVTHFQFLSWPDYGVPSSAASLIDFLRVVRSQQ 491

  Fly   224 ----GCL-SRDVG-----PAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMG 278
                |.| :|..|     |.||||||||||:||||.:|.||..:::.|..||.:.:..:|:.|..
  Rat   492 SMAVGSLGARSKGQCPEPPIVVHCSAGIGRTGTFCSLDICLAQLEELGTLNVFQTVSRMRTQRAF 556

  Fly   279 LIQTADQLDFSYQAIIE 295
            .|||.:|..|.|:||:|
  Rat   557 SIQTPEQYYFCYKAILE 573

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	103/275 (37%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	95/247 (38%)
Ptpn9	NP_001013058.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..21
		CRAL_TRIO_N	20..66	CDD:215024
		SEC14	90..238	CDD:214706
		PTPc	302..573	CDD:214550	103/275 (37%)
		PTPc	329..573	CDD:238006	95/249 (38%)
		Substrate binding. /evidence=ECO:0000250	515..521		5/5 (100%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	1	0.960	-	-
	4	3.870