Protein Alignment Ptp61F and PTPN18

DIOPT Version :10

• Sequence 1: NP_476687.1
• Gene: Ptp61F / 38160
• FlyBaseID: FBgn0267487
• Length: 548
• Species: Drosophila melanogaster
• Sequence 2: XP_006712480.1
• Gene: PTPN18 / 26469
• HGNCID: 9649
• Length: 464
• Species: Homo sapiens
• Alignment Length: 341
• Identity: 104/341 - (30%)
• Similarity: 156/341 - (45%)
• Gaps: 56/341 - (16%)

  Fly    51 STSESERHTNRGLNRYRDVNPYDHSRIVL----KRGSVDYINANLVQLERAERQYILTQGPLVDT 111
            ||....|..|...|||:||.|||.:|::|    :.|..||||.|.::.......||.|||||..|
Human    47 STVAGSRPENVRKNRYKDVLPYDQTRVILSLLQEEGHSDYINGNFIRGVDGSLAYIATQGPLPHT 111

  Fly   112 VGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQN-- 174
            :..||.:|||...:.:||..:.:|..:.:|..||..|..     .|......:.|:: |.:.|
Human   112 LLDFWRLVWEFGVKVILMACREIENGRKRCERYWAQEQE-----PLQTGLFCITLIK-EKWLNED 170

  Fly   175 FVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVR---DSGCLSRDVGPAVVH 236
            .:.|..|:|  ..::||.|.|..|.:|||.|:||||:..|..:::.|   .||     ..|..||
Human   171 IMLRTLKVT--FQKESRSVYQLQYMSWPDRGVPSSPDHMLAMVEEARRLQGSG-----PEPLCVH 228

  Fly   237 CSAGIGRSGTFCLVDCC--LVLIDKY-GECNVSKVLCELRSYRMGLIQTADQLDF---------- 288
            ||||.||:|..|.||..  |:|.... .:.::..|:.::|..|...:||.:|..|
Human   229 CSAGCGRTGVLCTVDYVRQLLLTQMIPPDFSLFDVVLKMRKQRPAAVQTEEQYRFLYHTVAQMFC 293

  Fly   289 --------SYQAIIEGIKKLHDPT-FLDAEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNS 344
                    .||.|.|....|:|.. ||...:.|::          :|.|....::|:::|.:|
Human   294 STLQNASPHYQNIKENCAPLYDDALFLRTPQALLA----------IPRPPGGVLRSISVPGSP-- 346

  Fly   345 GGILSLNMRAAQANGA 360
            |..::......|..||
Human   347 GHAMADTYAVVQKRGA 362

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc-N1_2	63..291	CDD:350393	82/257 (32%)
PTPN18	XP_006712480.1	PTPc-N18	27..292	CDD:350451	86/257 (33%)