DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptprz1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_037212.2	Gene:	Ptprz1 / 25613	RGDID:	3455	Length:	2316	Species:	Rattus norvegicus

Alignment Length:	403	Identity:	123/403 - (30%)
Similarity:	182/403 - (45%)	Gaps:	80/403 - (19%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FYKEICETCDREAKEKQFSTSESERH-TNRGLNRYRDVNPYDHSRIVL-----KRGSV-DYINAN 90
            ||:|: ::|..:..    .|::|..| .|:..|||.::..|||||:.|     |.|.: ||||||
  Rat  1728 FYQEV-QSCTVDLG----ITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINAN 1787

  Fly    91 LVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAL 155
            .|......:.||..||||..|...||.|:||.....::|:..|:||.:.||..|||.:...:...
  Rat  1788 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSEEYGS 1852

  Fly   156 KLPHVKLTVELVRLETYQNFVRRWFKL---TDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFL 217
            .|.:.| .|:::...|.:||..|..|:   :.......|.|.|:|||.|||.|:|......|.|
  Rat  1853 FLVNQK-NVQVLAYYTVRNFTLRNTKIKKGSQKGRSSGRLVTQYHYTQWPDMGVPEYSLPVLAF- 1915

  Fly   218 QQVRDSGCLSRD-VGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQ 281
              ||.:....|. |||.|||||||:||:||:.::|..|..|...|..|:...|..:||.|..|:|
  Rat  1916 --VRKTAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQRNYLVQ 1978

  Fly   282 TADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTE---------THTLDELPPP-----LPPR 332
            |.:|..|.:..::|.|               :|.:||         .:|| .:|.|     |..:
  Rat  1979 TEEQYVFIHDTLVEAI---------------LSKETEVPDSHIHSYVNTL-LIPGPSGKTKLEKQ 2027

  Fly   333 VQSLN--------------------------LPLAPNSGGILSLNMRAAQ-ANGAESIGKELSKD 370
            .|.|:                          :|:..:..||.||:..... .|.:..:|...|.:
  Rat  2028 FQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMGYYQSNE 2092

  Fly   371 ALNNFINQHDMIH 383
            .:   |.||.::|
  Rat  2093 FI---ITQHPLLH 2102

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	98/271 (36%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	91/242 (38%)
Ptprz1	NP_037212.2	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..401	CDD:278470
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	433..499
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	518..537
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	586..624
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	636..720
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1141..1172
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1204..1228
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1401..1521
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1545..1622
		PTPc	1717..1992	CDD:214550	99/272 (36%)
		PTPc	1753..1992	CDD:238006	91/242 (38%)
		Substrate binding. /evidence=ECO:0000250	1934..1940		4/5 (80%)
		PTPc	2023..2281	CDD:214550	15/83 (18%)
		PTPc	2051..2281	CDD:238006	12/55 (22%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	3	2.810