DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_038960209.1	Gene:	Ptpn1 / 24697	RGDID:	61965	Length:	451	Species:	Rattus norvegicus

Alignment Length:	420	Identity:	168/420 - (40%)
Similarity:	230/420 - (54%)	Gaps:	67/420 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    60 NRGLNRYRDVNPYDHSRIVLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKS 124
            |:..||||||:|:|||||.|.:...|||||:|:::|.|:|.||||||||.:|.||||.|||||||
  Rat    59 NKNRNRYRDVSPFDHSRIKLHQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKS 123

  Fly   125 RAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQ 189
            |.|:|||::|||..:||..|||.:...:......::|||:....:::|  :..|..:|.:|.||:
  Rat   124 RGVVMLNRIMEKGSLKCAQYWPQKEEKEMVFDDTNLKLTLISEDVKSY--YTVRQLELENLATQE 186

  Fly   190 SREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCL 254
            :||::.||||||||||:|.||.:||.||.:||:||.||.:.||.||||||||||||||||.|.||
  Rat   187 AREILHFHYTTWPDFGVPESPASFLNFLFKVRESGSLSPEHGPIVVHCSAGIGRSGTFCLADTCL 251

  Fly   255 VLIDKY---GECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIK-KLHDPTFLDAEEPLISN 315
            :|:||.   ...::.|||.|:|.:|||||||||||.|||.|:|||.| .:.|.:..|..:.|...
  Rat   252 LLMDKRKDPSSVDIKKVLLEMRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSHE 316

  Fly   316 DTETHTLDELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHD 380
            |.|.......|||.||:     ..|.|::|..                 |||        .:.|.
  Rat   317 DLEPPPEHVPPPPRPPK-----RTLEPHNGKC-----------------KEL--------FSNHQ 351

  Fly   381 MIHDAEVADSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATT 445
            .:.:                  :|..|||.|        ..|:....:|..|....::.......
  Rat   352 WVSE------------------ESCEDEDIL--------AREESRAPSIAVHSMSSMSQDTEVRK 390

  Fly   446 QP-----HADDVNANNEKPAVPVDEQHKAN 470
            :.     .:...:...|:...|.:|:.||:
  Rat   391 RMVGGGLQSAQASVPTEEELSPTEEEQKAH 420

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	134/237 (57%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	133/235 (57%)
Ptpn1	XP_038960209.1	PTPc-N1	38..311	CDD:350456	140/253 (55%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1686
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	314	1.000	Inparanoid score	I2487
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm44384
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	LDO	PTHR46047
Phylome	1	0.910	-	-
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	12	11.870