DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptprz1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_006505075.1	Gene:	Ptprz1 / 19283	MGIID:	97816	Length:	2318	Species:	Mus musculus

Alignment Length:	409	Identity:	126/409 - (30%)
Similarity:	186/409 - (45%)	Gaps:	86/409 - (21%)

- Green bases have known domain annotations that are detailed below.

  Fly    33 FYKEICETCDREAKEKQFSTSESERH-TNRGLNRYRDVNPYDHSRIVL-----KRGSV-DYINAN 90
            ||:|: ::|..:..    .|::|..| .|:..|||.::..|||||:.|     |.|.: ||||||
Mouse  1724 FYQEV-QSCTADLG----ITADSSNHPDNKHKNRYVNIVAYDHSRVKLTQLAEKDGKLTDYINAN 1783

  Fly    91 LVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKAL 155
            .|......:.||..||||..|...||.|:||.....::|:..|:||.:.||..|||.:...:...
Mouse  1784 YVDGYNRPKAYIAAQGPLKSTAEDFWRMIWEHNVEVIVMITNLVEKGRRKCDQYWPTDGSEEYGS 1848

  Fly   156 KLPHVKLTVELVRLETYQNFVRRWFKLTDLE-----TQQSRE----VMQFHYTTWPDFGIPSSPN 211
            .|.:.| :|:::...|.:||..|..||..|.     :|:.|.    |.|:|||.|||.|:|....
Mouse  1849 FLVNQK-SVQVLAYYTVRNFTLRNTKLKKLSELFQGSQKGRSSGRLVTQYHYTQWPDMGVPEYSL 1912

  Fly   212 AFLKFLQQVRDSGCLSRD-VGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSY 275
            ..|.|   ||.:....|. |||.|||||||:||:||:.::|..|..|...|..|:...|..:||.
Mouse  1913 PVLAF---VRKAAQAKRHAVGPVVVHCSAGVGRTGTYIVLDSMLQQIQHEGTVNIFGFLKHIRSQ 1974

  Fly   276 RMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTE---------THTLDELPPP--- 328
            |..|:||.:|..|.:..::|.|               :|.:||         .:|| .:|.|
Mouse  1975 RNYLVQTEEQYVFIHDTLVEAI---------------LSKETEVPDSHIHSYVNTL-LIPGPTGK 2023

  Fly   329 --LPPRVQSLN--------------------------LPLAPNSGGILSLNMRAAQ-ANGAESIG 364
              |..:.|.|:                          :|:..:..||.||:..... .|.:..:|
Mouse  2024 TKLEKQFQLLSQSNILQSDYSTALKQCNREKNRTSSIIPVERSRVGISSLSGEGTDYINASYIMG 2088

  Fly   365 KELSKDALNNFINQHDMIH 383
            ...|.:.:   |.||.::|
Mouse  2089 YYQSNEFI---ITQHPLLH 2104

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	101/277 (36%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	94/248 (38%)
Ptprz1	XP_006505075.1	alpha_CARP_receptor_like	45..298	CDD:239396
		fn3	313..395	CDD:365830
		PTP_DSP_cys	1714..1997	CDD:391942	104/296 (35%)
		R-PTP-Z-2	2080..2283	CDD:350507	7/28 (25%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810