DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptprg

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_033007.2	Gene:	Ptprg / 19270	MGIID:	97814	Length:	1442	Species:	Mus musculus

Alignment Length:	388	Identity:	121/388 - (31%)
Similarity:	174/388 - (44%)	Gaps:	61/388 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    34 YKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLK------RGSVDYINANLV 92
            :.|..|...|...:...:...|....|:..|||.::..|||||:.|:      ....||||||.|
Mouse   845 FSEDFEEVQRCTADMNITAEHSNHPDNKHKNRYINILAYDHSRVKLRPLPGKDSKHSDYINANYV 909

  Fly    93 QLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGAD----- 152
            ......:.||.|||||..|...||.|:|||.:..::|:..|:||.:.||..|||.|...:
Mouse   910 DGYNKAKAYIATQGPLKSTFEDFWRMIWEQNTGIIIMITNLVEKGRRKCDQYWPTENTEEYGNII 974

  Fly   153 ---KALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFL 214
               |:.|: |...||.  ||......|::..|......|..|.|:|:|||.|||.|:|......|
Mouse   975 VTLKSTKV-HACYTVR--RLSVRNTKVKKGQKGNPKGRQNERTVIQYHYTQWPDMGVPEYALPVL 1036

  Fly   215 KFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGL 279
            .|::  |.|.....|:||.:||||||:||:||:.::|..|..|......||...|..:|:.|..|
Mouse  1037 TFVR--RSSAARMPDMGPVLVHCSAGVGRTGTYIVIDSMLQQIKDKSTVNVLGFLKHIRTQRNYL 1099

  Fly   280 IQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLNLPLAPNS 344
            :||.:|..|.:.|::|.|        |..|..:.|:...::               :|..|.|..
Mouse  1100 VQTEEQYIFIHDALLEAI--------LGKETEVSSSQLHSY---------------VNSILIPGV 1141

  Fly   345 GG----------ILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLP 397
            ||          |...|.:..:...|:   ||.:|:.     |::..:..||.| ...|.|||
Mouse  1142 GGKTRLEKQFKLITQCNAKYVECFSAQ---KECNKEK-----NRNSSVVPAERA-RVGLAPLP 1195

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	97/274 (35%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	92/246 (37%)
Ptprg	NP_033007.2	PLN02179	17..272	CDD:177835
		alpha_CARP_receptor_like	67..319	CDD:239396
		FN3	348..438	CDD:238020
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	461..480
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	557..726
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	769..788
		PTPc	844..1115	CDD:214550	97/274 (35%)
		PTPc	873..1115	CDD:238006	92/246 (37%)
		Substrate binding. /evidence=ECO:0000250	1057..1063		4/5 (80%)
		PTPc	1147..1405	CDD:214550	14/58 (24%)
		PTPc	1174..1405	CDD:238006	8/28 (29%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1412..1442
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910