DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn22

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_033005.1	Gene:	Ptpn22 / 19260	MGIID:	107170	Length:	802	Species:	Mus musculus

Alignment Length:	620	Identity:	149/620 - (24%)
Similarity:	236/620 - (38%)	Gaps:	138/620 - (22%)

- Green bases have known domain annotations that are detailed below.

  Fly    18 QIEAEYKDKGPQWHRFYKEICETCDREAK---EKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL 79
            |:..|.:.|......|..|..:...:..|   :|.:.|:.::|..|...|||:|:.|||||.:.|
Mouse     9 QLLKEAQKKKLNSEEFASEFLKLKRQSTKYKADKIYPTTVAQRPKNIKKNRYKDILPYDHSLVEL 73

  Fly    80 KRGSVD----YINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIK 140
            ...:.|    ||||:.::.....:.||.|||||..|:..||.|:||.:...::|.....|..:.|
Mouse    74 SLLTSDEDSSYINASFIKGVYGPKAYIATQGPLSTTLLDFWRMIWEYRILVIVMACMEFEMGKKK 138

  Fly   141 CHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQ---QSREVMQFHYTTWP 202
            |..||. |.| :..|:.....::.|..:.::.       :|:..|:.:   ::|.:.||||..||
Mouse   139 CERYWA-EPG-ETQLQFGPFSISCEAEKKKSD-------YKIRTLKAKFNNETRIIYQFHYKNWP 194

  Fly   203 DFGIPSSPNAFLKFLQQVRDSGCLSR-DVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYG----E 262
            |..:|||.:..|:.:..:|   |... |..|..:|||||.||:|..|.||...:|: |.|    .
Mouse   195 DHDVPSSIDPILQLIWDMR---CYQEDDCVPICIHCSAGCGRTGVICAVDYTWMLL-KDGIIPKN 255

  Fly   263 CNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKKLHD---PTFLDAE---EPLISNDTETHT 321
            .:|..::.|:|:.|..|:||.:|.:..|.|::|..|:..|   ...|..|   :..|...:.|..
Mouse   256 FSVFNLIQEMRTQRPSLVQTQEQYELVYSAVLELFKRHMDVISDNHLGREIQAQCSIPEQSLTVE 320

  Fly   322 LDELPPPLP-------------------------------------------------PRVQSLN 337
            .|..|..||                                                 |....|.
Mouse   321 ADSCPLDLPKNAMRDVKTTNQHSKQGAEAESTGGSSLGLRTSTMNAEEELVLHSAKSSPSFNCLE 385

  Fly   338 LPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNF-------------INQHDMIHDA---- 385
            |....|:..:::.|   .||..:..:|:.|.|....:|             ||..|..|::
Mouse   386 LNCGCNNKAVITRN---GQARASPVVGEPLQKYQSLDFGSMLFGSCPSALPINTADRYHNSKGPV 447

  Fly   386 EVADSRPLPPLPVRAFND-----------SDSDEDYLLDDDDEDD----TDEDEEYETINEHDAD 435
            :...|.|...:..|..||           |...|.|.|.:.....    :.|:..|......||.
Mouse   448 KRTKSTPFELIQQRKTNDLAVGDGFSCLESQLHEHYSLRELQVQRVAHVSSEELNYSLPGACDAS 512

  Fly   436 PVNGHVPATTQPH-----ADDVNANNEKP-----AVPVDEQHKANGIDPIPGQLPAS-------- 482
            .|..|.|...:.|     |:|...::..|     .:..|...|.:|.......||||
Mouse   513 CVPRHSPGALRVHLYTSLAEDPYFSSSPPNSADSKMSFDLPEKQDGATSPGALLPASSTTSFFYS 577

  Fly   483 -PENELKRRKRNEYQASLEQKVNDMKRKQRENEDK 516
             |.:.|.......:...|.|: ..::...|..:|:
Mouse   578 NPHDSLVMNTLTSFSPPLNQE-TAVEAPSRRTDDE 611

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	86/275 (31%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	80/244 (33%)
Ptpn22	NP_033005.1	PTPc-N22	57..290	CDD:350450	81/245 (33%)
		Substrate binding. /evidence=ECO:0000250	227..233		4/5 (80%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	330..358		0/27 (0%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	536..564		4/27 (15%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	597..619		3/16 (19%)
		Interaction with CSK. /evidence=ECO:0000269\|PubMed:8890164	613..621
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	653..695
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	713..802
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	2	1.810