DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn2

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001120649.1	Gene:	Ptpn2 / 19255	MGIID:	97806	Length:	406	Species:	Mus musculus

Alignment Length:	536	Identity:	178/536 - (33%)
Similarity:	254/536 - (47%)	Gaps:	149/536 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 AARLQIEAEYKDKGPQWHRFYKEI-CETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRI 77
            :|.::.|.|..|...:|...|.|| .|:.|...:..:|.       .||..||||||:||||||:
Mouse     2 SATIEREFEELDAQCRWQPLYLEIRNESHDYPHRVAKFP-------ENRNRNRYRDVSPYDHSRV 59

  Fly    78 VLKRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCH 142
            .|:....|||||:||.:|.|:|.||||||||.:|..|||||||:||::||:|||:.:||:.:||.
Mouse    60 KLQSTENDYINASLVDIEEAQRSYILTQGPLPNTCCHFWLMVWQQKTKAVVMLNRTVEKESVKCA 124

  Fly   143 LYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIP 207
            .|||.:   |:.:.......:|:|:..:....:.....:|.::.|.::|.:..||||||||||:|
Mouse   125 QYWPTD---DREMVFKETGFSVKLLSEDVKSYYTVHLLQLENINTGETRTISHFHYTTWPDFGVP 186

  Fly   208 SSPNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCEL 272
            .||.:||.||.:||:||||:.|.||||:||||||||||||.|||.||||::|..:.||.::|..:
Mouse   187 ESPASFLNFLFKVRESGCLTPDHGPAVIHCSAGIGRSGTFSLVDTCLVLMEKGEDVNVKQLLLNM 251

  Fly   273 RSYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQSLN 337
            |.||||||||.|||.|||.|||||.|                     :|..:
Mouse   252 RKYRMGLIQTPDQLRFSYMAIIEGAK---------------------YTKGD------------- 282

  Fly   338 LPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFN 402
                                :..:...|||||:.|:                       |:
Mouse   283 --------------------SNIQKRWKELSKEDLS-----------------------PI---- 300

  Fly   403 DSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQH 467
                             .|..:....:.:::...:.                         .|..
Mouse   301 -----------------CDHSQNRVMVEKYNGKRIG-------------------------SEDE 323

  Fly   468 KANGI-DPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQLAAKKR----RSLL 527
            |..|: ..:...:..|.|:.|::|.|.:.:|:..|||..||::..|.|.|    :||    :.:|
Mouse   324 KLTGLPSKVQDTVEESSESILRKRIREDRKATTAQKVQQMKQRLNETERK----RKRWLYWQPIL 384

  Fly   528 T------YIAAGVVVG 537
            |      .|..|.:||
Mouse   385 TKMGFVSVILVGALVG 400

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	135/261 (52%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	127/232 (55%)
Ptpn2	NP_001120649.1	PTPc	5..274	CDD:214550	139/278 (50%)
		PTPc	45..274	CDD:238006	127/231 (55%)
		Substrate binding. /evidence=ECO:0000250	216..222		5/5 (100%)
		Endoplasmic reticulum location. /evidence=ECO:0000250	341..406		21/64 (33%)
		Mediates interaction with STX17. /evidence=ECO:0000250	371..406		10/34 (29%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167850395
Domainoid	1	1.000	275	1.000	Domainoid score	I1745
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	1	1.000	-	-		H7497
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2535
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm42325
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	O	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	15	14.830