DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn1

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_035331.3	Gene:	Ptpn1 / 19246	MGIID:	97805	Length:	432	Species:	Mus musculus

Alignment Length:	335	Identity:	158/335 - (47%)
Similarity:	216/335 - (64%)	Gaps:	19/335 - (5%)

- Green bases have known domain annotations that are detailed below.

  Fly    17 LQIEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVL 79
            :::|.|::  ||...|...|::|    ..||.:.....::..::.||  ||||||:|:|||||.|
Mouse     1 MEMEKEFEEIDKAGNWAAIYQDI----RHEASDFPCKVAKLPKNKNR--NRYRDVSPFDHSRIKL 59

  Fly    80 KRGSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLY 144
            .:...|||||:|:::|.|:|.||||||||.:|.||||.||||||||.|:|||::|||..:||..|
Mouse    60 HQEDNDYINASLIKMEEAQRSYILTQGPLPNTCGHFWEMVWEQKSRGVVMLNRIMEKGSLKCAQY 124

  Fly   145 WPNEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSS 209
            ||.:  .:|.:......|.:.|:..:....:..|..:|.:|.|:::||::.||||||||||:|.|
Mouse   125 WPQQ--EEKEMVFDDTGLKLTLISEDVKSYYTVRQLELENLTTKETREILHFHYTTWPDFGVPES 187

  Fly   210 PNAFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKY---GECNVSKVLCE 271
            |.:||.||.:||:||.||.:.||.||||||||||||||||.|.||:|:||.   ...::.|||.|
Mouse   188 PASFLNFLFKVRESGSLSLEHGPIVVHCSAGIGRSGTFCLADTCLLLMDKRKDPSSVDIKKVLLE 252

  Fly   272 LRSYRMGLIQTADQLDFSYQAIIEGIK-KLHDPTFLDAEEPLISNDTETHTLDELPPPLPPRVQS 335
            :|.:|||||||||||.|||.|:|||.| .:.|.:..|..:.|...|.:.......|||.||:
Mouse   253 MRRFRMGLIQTADQLRFSYLAVIEGAKFIMGDSSVQDQWKELSREDLDLPPEHVPPPPRPPK--- 314

  Fly   336 LNLPLAPNSG 345
              ..|.|::|
Mouse   315 --RTLEPHNG 322

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	137/263 (52%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	131/235 (56%)
Ptpn1	NP_035331.3	PTPc	3..276	CDD:214550	142/280 (51%)
		PTPc	43..276	CDD:238006	132/236 (56%)
		Substrate binding. /evidence=ECO:0000250	215..221		5/5 (100%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	297..322		8/29 (28%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	335..399
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	275	1.000	Domainoid score	I1745
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	1	1.000	-	-
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	316	1.000	Inparanoid score	I2535
Isobase	1	0.950	-	0	Normalized mean entropy	S2559
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm42325
orthoMCL	1	0.900	-	-		OOG6_104767
Panther	1	1.100	-	-	LDO	PTHR46047
Phylome	1	0.910	-	-
RoundUp	1	1.030	-	avgDist	Average_Evolutionary_Distance	R4733
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	13	12.840