DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Ptp61F and ptp-4

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_001255470.1	Gene:	ptp-4 / 177898	WormBaseID:	WBGene00010558	Length:	1159	Species:	Caenorhabditis elegans

Alignment Length:	483	Identity:	124/483 - (25%)
Similarity:	188/483 - (38%)	Gaps:	139/483 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    51 STSESERHTNRGLNRYRDVNPYDHSRIVLK--RGSVDYINANLVQLERAERQYILTQGPLVDTVG 113
            |.|.|:.::.:  |||.::...:.:||.|.  .|: ||||||.|........||.||.||..|..
Worm   665 SNSSSDENSQK--NRYNNIGAIEATRIRLNSPTGN-DYINANYVDSCNERNAYIATQAPLPSTFS 726

  Fly   114 HFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLETYQNFVRR 178
            .||.|:|:::|..::.:..::|..:.||..|||::..:.:...    ...|.||...|..:|..|
Worm   727 DFWSMIWQERSNIIVCITNMVEDGKRKCDQYWPSQQDSPQTFG----NYQVTLVSESTNAHFSHR 787

  Fly   179 WFKLTDLETQQS-----REVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDVGPAVVHCS 238
               :.||:..::     |:|.|.|:..|||.|:|||....|.|:....|    ....||.|||||
Worm   788 ---ILDLKIAKAVPAVERKVHQLHFMGWPDHGVPSSVFPLLSFVHYTSD----IHSTGPVVVHCS 845

  Fly   239 AGIGRSGTFCLVDCCLVLIDKYGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIE----GIKK 299
            ||:||||::.|||.....:..:...||...|..:|..|..|:||.:|..|.::||.:    ||.:
Worm   846 AGVGRSGSYILVDSMRRHLISFRRLNVQGHLTHMRRQRAKLVQTLEQYIFCHEAIRQLIRHGITR 910

  Fly   300 LHDPTFLD-----AEEP-----------------------LISNDTET----HTLDELPPPLPPR 332
            :|...|:.     :||.                       ||.:|..|    |..||.
Worm   911 VHSDLFMRYLHYLSEENLNGKTRMQLQFEDICDCKHQPRCLIESDVITLPGYHRSDEF------- 968

  Fly   333 VQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFI--NQHD--------MIHDAEV 387
                               |..:..|..|.:.:...:..:...:  ||.|        .|:|.|:
Worm   969 -------------------MVGSWGNECEDLWRLTWQQKVQTIVILNQRDSFWRKLPSCIYDGEI 1014

  Fly   388 ADSRPLPPLPVRAFNDSDSDEDYLLDDDDED-------------DTD-----EDEEYETINEHDA 434
                          .....|...||..||:.             |||     |:.:.:.|..|||
Worm  1015 --------------QLQHGDNFVLLQKDDQQLCVRIVNVSRADLDTDFWREIENVQKQRITYHDA 1065

  Fly   435 DPVNGHVPATTQPHADDVNANNEKPAVP 462
            ..:              :.|:...|:||
Worm  1066 PLL--------------ILAHKYPPSVP 1079

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	85/250 (34%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	82/239 (34%)
ptp-4	NP_001255470.1	IG_like	<83..120	CDD:214653
		FN3	140..232	CDD:238020
		FN3	237..326	CDD:238020
		FN3	338..435	CDD:238020
		PTPc	642..900	CDD:214550	83/248 (33%)
		PTPc	675..900	CDD:238006	80/238 (34%)
		Y_phosphatase	<977..1128	CDD:278528	24/131 (18%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910