DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and Ptpn23

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	NP_476552.2	Gene:	Ptpn23 / 117552	RGDID:	619892	Length:	1666	Species:	Rattus norvegicus

Alignment Length:	511	Identity:	125/511 - (24%)
Similarity:	201/511 - (39%)	Gaps:	134/511 - (26%)

- Green bases have known domain annotations that are detailed below.

  Fly    54 ESERHTNRG-----------LNRYRDVNPYDHSRIVLKRGSVDYINANLVQ-LERAERQYILTQG 106
            |::.|..||           .||::||.|||.:|:||:.|..|||||:.|: |.......:.||.
  Rat  1230 EAQEHDARGRSIAIARCYSLKNRHQDVMPYDSNRVVLRSGKDDYINASCVEGLSPYCPPLVATQA 1294

  Fly   107 PLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWPNEMGADKALKLPHVKLTVELVRLET 171
            ||..|...|||||.|||...::||....|.::.|...|:|.|.|.    .:.|..|:|.|..:.|
  Rat  1295 PLPGTAADFWLMVHEQKVSVIVMLVSEAEMEKQKVARYFPIERGQ----PMVHGALSVALSSVRT 1355

  Fly   172 YQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPNAFLKFLQQVRDSGCLSRDV-GPAVV 235
            ....|.|...|...:....|.::..|:.|||:.|:|.||...|:|:|:|.......|.: .|.||
  Rat  1356 TDTHVERVLSLQFRDQSLKRSLVHLHFPTWPELGLPDSPGNLLRFIQEVHAHYLHQRPLHTPIVV 1420

  Fly   236 HCSAGIGRSGTFCLVDCCLVLIDK-YGECNVSKVLCELRSYRMGLIQTADQLDFSYQAIIEGIKK 299
            |||:|:||:|.|.|:...:..::. .|...:.:::..:|..|..::|....|.|.::|::..:::
  Rat  1421 HCSSGVGRTGAFALLYAAVQEVEAGSGIPELPQLVRRMRQQRKHMLQEKLHLKFCHEALVRHVEQ 1485

  Fly   300 LHDPTFLDAEEPLISNDTETHTLDELPPP--------------LPPRVQSL----NLPLAPNSGG 346
            :                .:.|   .:|||              ||...|.|    ::|::.....
  Rat  1486 V----------------LQRH---GVPPPGKPVASMSVSQKSHLPQDSQDLVLGGDVPISSIQAT 1531

  Fly   347 ILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVADSRPLPPLPVRAFNDSDSDEDYL 411
            |..|::|  ...|.:|....|..      :.:...:..|.:.:..|.||
  Rat  1532 IAKLSIR--PLGGLDSPAASLPS------LVEPPGLPPASLPEPTPAPP---------------- 1572

  Fly   412 LDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVNANNEKPAVPVDEQHKANGIDPIP 476
                                ....|.:..:|...||        .|:|:||     :|..:.|
  Rat  1573 --------------------SSPPPPSSPLPEPPQP--------EEEPSVP-----EAPSLGP-- 1602

  Fly   477 GQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQLAAKKRRSLLTYIAA 532
                  |.:.|      |..|||..:...:        |..|..|:|.|...::.|
  Rat  1603 ------PSSSL------ELLASLTPEAFSL--------DSSLRGKQRMSKQNFLQA 1638

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	84/254 (33%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	81/246 (33%)
Ptpn23	NP_476552.2	BRO1_HD-PTP_like	2..357	CDD:185762
		V_HD-PTP_like	362..702	CDD:185747
		ALIX_LYPXL_bnd	417..703	CDD:290660
		Y_phosphatase	1250..1480	CDD:278528	80/233 (34%)
		PTPc	1250..1479	CDD:238006	79/232 (34%)
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	1	0.900	-	-		E2759_KOG0789
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	1	1.000	-	-
TreeFam	0	0.000	Not matched by this tool.
	2	1.900