DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment Ptp61F and ptpn2

DIOPT Version :9

Sequence 1:	NP_476687.1	Gene:	Ptp61F / 38160	FlyBaseID:	FBgn0267487	Length:	548	Species:	Drosophila melanogaster
Sequence 2:	XP_004915309.2	Gene:	ptpn2 / 100492067	XenbaseID:	XB-GENE-953563	Length:	477	Species:	Xenopus tropicalis

Alignment Length:	528	Identity:	185/528 - (35%)
Similarity:	278/528 - (52%)	Gaps:	74/528 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    19 IEAEYK--DKGPQWHRFYKEICETCDREAKEKQFSTSESERHTNRGLNRYRDVNPYDHSRIVLKR 81
            :|.|::  |:...|:..|.:|      ..|........::...|:..|||||||||||||:.|:.
Frog     1 MEKEFREIDEENGWNSSYGDI------RNKSPVLPNKIAKNPENKNRNRYRDVNPYDHSRVKLQN 59

  Fly    82 GSVDYINANLVQLERAERQYILTQGPLVDTVGHFWLMVWEQKSRAVLMLNKLMEKKQIKCHLYWP 146
            ...|||||:||.:|.|:|.||||||||.:|..|||||||:|||:|::|||:::||..:||..|||
Frog    60 VENDYINASLVVVEEAQRSYILTQGPLPNTCCHFWLMVWQQKSKAIVMLNRIIEKDAVKCAQYWP 124

  Fly   147 NEMGADKALKLPHVKLTVELVRLETYQNFVRRWFKLTDLETQQSREVMQFHYTTWPDFGIPSSPN 211
            ..  .::||......|.|:||..:....:..|..:|.|::|.::|::..||||||||||:|.||.
Frog   125 TP--EEEALFYKETGLCVKLVSEDIKSYYTVRVLQLQDIKTGEARDIFHFHYTTWPDFGVPQSPA 187

  Fly   212 AFLKFLQQVRDSGCLSRDVGPAVVHCSAGIGRSGTFCLVDCCLVLIDKYGE-CNV--SKVLCELR 273
            :||.||.:||:||.||...|||||||||||||||||.|||.||||::|..: |:|  .:||..:|
Frog   188 SFLNFLFKVRESGSLSLQNGPAVVHCSAGIGRSGTFSLVDTCLVLMEKREDPCSVDIKQVLLNMR 252

  Fly   274 SYRMGLIQTADQLDFSYQAIIEGIKKLHDPTFLDAEEPLISNDTETHTLD--------------- 323
            :||||||||..||.|||.|:|||.|.:...:.|......:|.:.:...:|
Frog   253 NYRMGLIQTPGQLRFSYMAVIEGSKYIMGDSSLQDHWKELSQEDQCPKIDRLSFQRQCVERCNGN 317

  Fly   324 ELPPPLPPRVQSLNLPLAPNSGGILSLNMRAAQANGAESIGKELSKDALNNFINQHDMIHDAEVA 388
            .|.......::|.:.|....:|...||..|..|.:...|..::: ...|.:|:...:|
Frog   318 RLSDHGENTLESCSKPQDDGNGSPESLVRRRQQEDRKASTAQKV-HHILPSFVPAAEM------- 374

  Fly   389 DSRPLPPLPVRAFNDSDSDEDYLLDDDDEDDTDEDEEYETINEHDADPVNGHVPATTQPHADDVN 453
                               :|:..:..::||:.:::.|.::.....:..||:..:|..   .::|
Frog   375 -------------------QDHNKELSEDDDSLKEDSYFSLQRQPGEWYNGNRLSTED---QEIN 417

  Fly   454 ANNEKPAVPVDEQHKANGIDPIPGQLPASPENELKRRKRNEYQASLEQKVNDMKRKQRENEDKQL 518
            .||.:.::...:....|.            |:.|::|:|.:.:|...|||..:|:...|.|.|
Frog   418 ENNSESSIKPQDVGDGNA------------ESLLRKRRREDRKACTTQKVQKIKQMMNEVERK-- 468

  Fly   519 AAKKRRSL 526
              :||..|
Frog   469 --RKRPRL 474

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Ptp61F	NP_476687.1	PTPc	34..295	CDD:214550	136/263 (52%)
Ptp61F	NP_476687.1	PTPc	62..295	CDD:238006	132/235 (56%)
ptpn2	XP_004915309.2	PTPc	1..274	CDD:214550	140/280 (50%)
ptpn2	XP_004915309.2	PTPc	41..274	CDD:238006	132/234 (56%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	1	1.000	272	1.000	Domainoid score	I1768
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	1	1.000	-	-		H7497
Inparanoid	1	1.050	290	1.000	Inparanoid score	I2742
OMA	0	0.000	Not matched by this tool.
OrthoDB	1	1.010	-	-		D305231at33208
OrthoFinder	1	1.000	-	-		FOG0000704
OrthoInspector	1	1.000	-	-		otm47430
Panther	1	1.100	-	-	O	PTHR46047
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X2326
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	8	8.160