Protein Alignment KLK1 and alphaTry

DIOPT Version :9

• Sequence 1: NP_002248.1
• Gene: KLK1 / 3816
• HGNCID: 6357
• Length: 262
• Species: Homo sapiens
• Sequence 2: NP_476771.1
• Gene: alphaTry / 48316
• FlyBaseID: FBgn0003863
• Length: 256
• Species: Drosophila melanogaster
• Alignment Length: 270
• Identity: 80/270 - (29%)
• Similarity: 119/270 - (44%)
• Gaps: 40/270 - (14%)

Human     4 LVLCLALSLGGT---GAAPPIQSRIVGGWECEQHSQPWQAALYHFSTFQCGGILVHRQWVLTAAH 65
            |:..:..:||||   |..|.:..|||||......|.|||.:|....:..|||.:.....::||||
  Fly     7 LLSAVVCALGGTVPEGLLPQLDGRIVGGSATTISSFPWQISLQRSGSHSCGGSIYSANIIVTAAH 71

Human    66 CISD----------NYQLWLGRHNLFDDENTAQFVHVSESFPHPGFNMSLLENHTRQADEDYSHD 120
            |:..          ....|         .:......||....|.|:|.:.:.|           |
  Fly    72 CLQSVSASVLQVRAGSTYW---------SSGGVVAKVSSFKNHEGYNANTMVN-----------D 116

Human   121 LMLLRLTEPADTITDAVKVVELPTEEPEVGSTCLASGWGSIEPENFSFPDDLQCVDLKILPNDEC 185
            :.::||:... :.:.::|.:.|.|..|..|::...||||:....:.|.|..||.|::.|:...:|
  Fly   117 IAVIRLSSSL-SFSSSIKAISLATYNPANGASAAVSGWGTQSSGSSSIPSQLQYVNVNIVSQSQC 180

Human   186 KKA---HVQKVTDFMLCVGHLEGGKDTCVGDSGGPLMCDGVLQGVTSWGYVPCGTPNKPSVAVRV 247
            ..:   :..::.:.|:|..  ..|||.|.|||||||:..|||.||.|||| .|...|.|.|...|
  Fly   181 ASSTYGYGSQIRNTMICAA--ASGKDACQGDSGGPLVSGGVLVGVVSWGY-GCAYSNYPGVYADV 242

Human   248 LSYVKWIEDT 257
            .....|:..|
  Fly   243 AVLRSWVVST 252

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
KLK1	NP_002248.1	Tryp_SPc	25..257	CDD:238113	71/244 (29%)
alphaTry	NP_476771.1	Tryp_SPc	30..249	CDD:214473	71/242 (29%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	1	0.950	-	0	Normalized mean entropy	S5403
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	1	1.000	-	-		X21
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	3	2.860