DRSC/TRiP Functional Genomics Resources

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Protein Alignment CG2199 and ZNF160

DIOPT Version :9

Sequence 1:NP_728599.1 Gene:CG2199 / 38159 FlyBaseID:FBgn0035213 Length:733 Species:Drosophila melanogaster
Sequence 2:NP_001096073.1 Gene:ZNF160 / 90338 HGNCID:12948 Length:818 Species:Homo sapiens


Alignment Length:733 Identity:132/733 - (18%)
Similarity:239/733 - (32%) Gaps:195/733 - (26%)


- Green bases have known domain annotations that are detailed below.


  Fly    15 KEVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITHRSIPS-SLPIKICFVCTSTF-MSSAAL 77
            |..:|:.||            |.|     |......:||.|.| ..|.| |..|..|| :.|...
Human   255 KPYKCNECG------------KAF-----TQNSNLTSHRRIHSGEKPYK-CSECGKTFTVRSNLT 301

  Fly    78 IEKVRETVDRVQEQPAKKTKVAEIEEPSTQESDKKAVKVPKKNTTLRQRSKSIAAFPPSFVNGAN 142
            |.:|..|    .|:|.|..:..::...::..:..:.:...:|.....:..|:.        .|.:
Human   302 IHQVIHT----GEKPYKCHECGKVFRHNSYLATHRRIHTGEKPYKCNECGKAF--------RGHS 354

  Fly   143 TNTEIEIISASPKKLDKTPKK--QISRLFEDNLNDSVKLTPAKEVSSTKKAF-LNLFGNGGNDAI 204
            ..|..::|....|     |.|  :..:||..|.:    |.....:.:.:|.: .|..|.    |.
Human   355 NLTTHQLIHTGEK-----PFKCNECGKLFTQNSH----LISHWRIHTGEKPYKCNECGK----AF 406

  Fly   205 EVLTESEEEEDSDKGPITINTNN--FQCPECEFHAKFPKPYKEHLQKEHGLQRPRIYPCTLCIKT 267
            .|.:.....:       ||:|..  ::|.||....::......| ::.|..::|  |.|..|.|.
Human   407 SVRSSLAIHQ-------TIHTGEKPYKCNECGKVFRYNSYLGRH-RRVHTGEKP--YKCNECGKA 461

  Fly   268 FGVLKTLKNHLRDTHSRTFESEAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSK 332
            |.:...|..| :..|:.|                                       ||      
Human   462 FSMHSNLATH-QVIHTGT---------------------------------------KP------ 480

  Fly   333 EKKTEIKCNVETKVVDEIDDQVNNKKGTDSEDA----DQTQATKIASFKALNESLMKKRMLENVI 393
                 .|||..:||..:.....|:::....|..    :..:|..:.|....::::.........|
Human   481 -----FKCNECSKVFTQNSQLANHRRIHTGEKPYKCNECGKAFSVRSSLTTHQAIHSGEKPYKCI 540

  Fly   394 DSEYTFAINGSSASTPRADSNN--FQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSL 456
            :...:|.......|.....|..  ::|..|........|:..|.: ||:.:||  :||:.|.::.
Human   541 ECGKSFTQKSHLRSHRGIHSGEKPYKCNECGKVFAQTSQLARHWR-VHTGEKP--YKCNDCGRAF 602

  Fly   457 ATKQSLKTHMTLHADGAEAPNSSKR--KILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKA 519
            :.:.||..|..:|.  .|.|.....  |:.:..    ..|.|.:..:|.||.....:..::.:..
Human   603 SDRSSLTFHQAIHT--GEKPYKCHECGKVFRHN----SYLATHRRIHTGEKPYKCNECGKAFSMH 661

  Fly   520 AKFTNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTK 584
            :..|..|::...::      .:|.:..                                 .|...
Human   662 SNLTTHKVIHTGEK------PYKCNQC---------------------------------GKVFT 687

  Fly   585 KTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTAD 649
            :.||:.....|..|..|.:..:..|......:|.:.     :.|:...:|:|             
Human   688 QNSHLANHQRTHTGEKPYRCNECGKAFSVRSSLTTH-----QAIHTGKKPYK------------- 734

  Fly   650 ESTLSCDRCGKFVKSRQRLDSHMEKKHAAK--LQCTLCKEVYQNQMDYVAHFSNCGSEGGLPCGV 712
                 |:.|||.......|.:| .:.|..:  .:||.|.:.::.:.....|.:....|....|. 
Human   735 -----CNECGKVFTQNAHLANH-RRIHTGEKPYRCTECGKAFRVRSSLTTHMAIHTGEKRYKCN- 792

  Fly   713 ANCKKVFTEANFLSSHLR 730
             .|.|||.:::.|:||.|
Human   793 -ECGKVFRQSSNLASHHR 809

Known Domains:


Indicated by green bases in alignment.

GeneSequenceDomainRegion External IDIdentity
CG2199NP_728599.1 C2H2 Zn finger 418..439 CDD:275370 4/20 (20%)
C2H2 Zn finger 449..469 CDD:275370 5/19 (26%)
ZNF160NP_001096073.1 KRAB 8..68 CDD:214630
KRAB 8..47 CDD:279668
zf-C2H2 257..279 CDD:278523 8/38 (21%)
C2H2 Zn finger 259..279 CDD:275368 8/36 (22%)
zf-H2C2_2 271..295 CDD:290200 9/24 (38%)
C2H2 Zn finger 287..307 CDD:275368 7/19 (37%)
zf-H2C2_2 299..324 CDD:290200 6/28 (21%)
C2H2 Zn finger 315..335 CDD:275368 0/19 (0%)
zf-H2C2_2 327..350 CDD:290200 2/22 (9%)
C2H2 Zn finger 343..363 CDD:275368 3/27 (11%)
zf-H2C2_2 355..380 CDD:290200 7/29 (24%)
COG5048 367..810 CDD:227381 103/591 (17%)
C2H2 Zn finger 371..391 CDD:275368 4/23 (17%)
C2H2 Zn finger 399..419 CDD:275368 5/30 (17%)
zf-H2C2_2 411..436 CDD:290200 6/31 (19%)
C2H2 Zn finger 427..447 CDD:275368 4/20 (20%)
zf-H2C2_2 439..463 CDD:290200 7/26 (27%)
C2H2 Zn finger 455..475 CDD:275368 6/20 (30%)
C2H2 Zn finger 483..503 CDD:275368 5/19 (26%)
zf-H2C2_2 496..519 CDD:290200 3/22 (14%)
C2H2 Zn finger 511..531 CDD:275368 2/19 (11%)
zf-H2C2_2 523..548 CDD:290200 2/24 (8%)
C2H2 Zn finger 539..559 CDD:275368 3/19 (16%)
zf-H2C2_2 551..576 CDD:290200 4/24 (17%)
C2H2 Zn finger 567..587 CDD:275368 4/20 (20%)
C2H2 Zn finger 595..615 CDD:275368 5/19 (26%)
zf-H2C2_2 607..632 CDD:290200 7/26 (27%)
C2H2 Zn finger 623..643 CDD:275368 3/23 (13%)
zf-H2C2_2 635..659 CDD:290200 5/23 (22%)
C2H2 Zn finger 651..671 CDD:275368 2/19 (11%)
zf-H2C2_2 663..688 CDD:290200 4/63 (6%)
C2H2 Zn finger 679..699 CDD:275368 3/52 (6%)
zf-H2C2_2 691..715 CDD:290200 5/23 (22%)
C2H2 Zn finger 707..727 CDD:275368 2/24 (8%)
zf-H2C2_2 719..744 CDD:290200 8/47 (17%)
C2H2 Zn finger 735..755 CDD:275368 6/20 (30%)
zf-H2C2_2 747..770 CDD:290200 6/23 (26%)
C2H2 Zn finger 763..783 CDD:275368 4/19 (21%)
zf-H2C2_2 775..800 CDD:290200 7/26 (27%)
C2H2 Zn finger 791..811 CDD:275368 9/21 (43%)
Blue background indicates that the domain is not in the aligned region.


Information from Original Tools:


Tool Simple Score Weighted Score Original Tool Information
BLAST Result Score Score Type Cluster ID
Compara 1 0.930 - - C165142394
Domainoid 00.000 Not matched by this tool.
eggNOG 00.000 Not matched by this tool.
Hieranoid 00.000 Not matched by this tool.
Homologene 00.000 Not matched by this tool.
Inparanoid 00.000 Not matched by this tool.
Isobase 00.000 Not matched by this tool.
OMA 00.000 Not matched by this tool.
OrthoDB 00.000 Not matched by this tool.
OrthoFinder 00.000 Not matched by this tool.
OrthoInspector 00.000 Not matched by this tool.
orthoMCL 00.000 Not matched by this tool.
Panther 00.000 Not matched by this tool.
Phylome 00.000 Not matched by this tool.
RoundUp 00.000 Not matched by this tool.
SonicParanoid 00.000 Not matched by this tool.
SwiftOrtho 00.000 Not matched by this tool.
TreeFam 00.000 Not matched by this tool.
User_Submission 00.000 Not matched by this tool.
10.930

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