DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and ZNF208

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_009084.2	Gene:	ZNF208 / 7757	HGNCID:	12999	Length:	1280	Species:	Homo sapiens

Alignment Length:	850	Identity:	169/850 - (19%)
Similarity:	275/850 - (32%)	Gaps:	238/850 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QKEVRCDHCG-------TSQGSKSVFSGQKVF----LGRKITDVLETITHRSI-PSSLPIKICFV 66
            :|..:|:.||       |....|::.:|:|.:    .|:..:.|...|||::| ....|.| |..
Human   282 EKPNKCEECGKAFSKVSTLTTHKAIHAGEKPYKCKECGKAFSKVSTLITHKAIHAGEKPYK-CKE 345

  Fly    67 CTSTFMSSAALIEKVRETVDRVQEQPAKKTKVAEIEE-PSTQESDKKAVKVPKKNTTLRQRSKSI 130
            |...|...:.|   .:..|....|:|.|..:..:..: |||....|| :...:|.....:..|..
Human   346 CGKAFSKFSIL---TKHKVIHTGEKPYKCEECGKAYKWPSTLSYHKK-IHTGEKPYKCEECGKGF 406

  Fly   131 AAFPPSFVNGANTNTEIEIISASPKKLDKTPKK--QISRLF--EDNLNDSVKL----TPAKEVSS 187
            :.|        :..|:.|:|....|     |.|  :..:.|  ..||.:..|:    ||.|....
Human   407 SMF--------SILTKHEVIHTGEK-----PYKCEECGKAFNWSSNLMEHKKIHTGETPYKCEEC 458

  Fly   188 TKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPITINTNNFQCPECE--FHAKFPKPYK------ 244
            .|          |.....:||:.:...:.:|        .::|.||:  .||. .||||
Human   459 GK----------GFSMFSILTKHKVIHNGEK--------PYKCEECDKATHAG-EKPYKCEECGK 504

  Fly   245 ---------EHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNH-LRDTHSRTFESEAKTKAKE--- 296
                     || ::.|..::|  |.|..|.|:|.....|..| :..|..:.::.|...||.:
Human   505 AFNWSSNLMEH-KRIHTGEKP--YKCEECGKSFSTFSILTKHKVIHTGEKPYKCEECGKAYKWSS 566

  Fly   297 --SKEKEAKSGAK-NKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDDQVNNK- 357
              |..|:..:..| .|.:...|..|..:...|.|...:.||  ..||....|...::.....:|
Human   567 TLSYHKKIHTVEKPYKCEECGKAFNQSAILIKHKRIHTGEK--PYKCEECGKTFSKVSTLTTHKA 629

  Fly   358 -----KGTDSEDADQT--QATKIASFKALNE-----------------SLMKKRMLENVIDSEYT 398
                 |....::..:|  :.:.:.:.||::.                 |::.|..:.:..:..|
Human   630 IHAGEKPYKCKECGKTFIKVSTLTTHKAIHAGEKPYKCKECGKAFSKFSILTKHKVIHTGEKPY- 693

  Fly   399 FAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLK 463
                              :||.|......:..:.|| |.:|:.:||  :||..|.||.:|...|.
Human   694 ------------------KCEECGKAFNWSSNLMEH-KRIHTGEKP--YKCEECGKSFSTFSVLT 737

  Fly   464 THMTLHADGAEAPNSSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKIL 528
            .|..:|.  .|.|..     .::..:......|.........||.|.|.::    ..|..||..:
Human   738 KHKVIHT--GEKPYK-----CEECGKAYKWSSTLSYHKKIHTVEKPYKCEE----CGKAFNRSAI 791

  Fly   529 ----------------QEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPR 577
                            :|..:....|....|.......|.|.:.|            :.|....:
Human   792 LIKHKRIHTDEKPYKCEECGKTFSKVSTLTTHKAIHAGEKPYKCK------------ECGKAFSK 844

  Fly   578 SPAKKTKKTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPH---KKAR 639
            .......|..|        .|..|.|.|:..|..|...||           :|:.:.|   |..:
Human   845 FSILTKHKVIH--------TGEKPYKCEECGKAYKWPSTL-----------SYHKKIHTGEKPYK 890

  Fly   640 LESIGDSTA-------------DESTLSCDRCGKFVKSRQRLDSHMEKKHAAK--LQCTLCKEVY 689
            .|..|...:             .|....|:.|||..........| :|.||.:  .:|..|.:.|
Human   891 CEECGKGFSMFSILTKHEVIHTGEKPYKCEECGKAFSWLSVFSKH-KKTHAGEKFYKCEACGKAY 954

  Fly   690 QNQMDYVAH-----------FSNCGS---------------EGGLPCGVANCKKVFTEANFLSSH 728
            ::......|           :..||.               .|..|.....|.|.|..::.|..|
Human   955 KSSSTLSYHKKIHTEEKPYKYEECGKGFSTFSILTKHKVIHTGEKPYKCEECGKAFNWSSNLMEH 1019

  Fly   729 LRKRH 733
             :|.|
Human  1020 -KKIH 1023

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	6/20 (30%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	7/19 (37%)
ZNF208	NP_009084.2	KRAB	4..64	CDD:214630
		KRAB	4..43	CDD:279668
		C2H2 Zn finger	175..195	CDD:275368
		C2H2 Zn finger	203..223	CDD:275368
		COG5048	227..619	CDD:227381	87/378 (23%)
		C2H2 Zn finger	231..251	CDD:275368
		C2H2 Zn finger	259..279	CDD:275368
		C2H2 Zn finger	287..307	CDD:275368	5/19 (26%)
		C2H2 Zn finger	315..335	CDD:275368	5/19 (26%)
		C2H2 Zn finger	343..363	CDD:275368	5/22 (23%)
		C2H2 Zn finger	371..391	CDD:275368	5/20 (25%)
		zf-H2C2_2	384..407	CDD:290200	4/23 (17%)
		C2H2 Zn finger	399..419	CDD:275368	4/27 (15%)
		C2H2 Zn finger	427..447	CDD:275368	4/19 (21%)
		zf-H2C2_2	439..463	CDD:290200	8/33 (24%)
		C2H2 Zn finger	455..475	CDD:275368	4/29 (14%)
		C2H2 Zn finger	499..519	CDD:275368	2/20 (10%)
		zf-H2C2_2	511..536	CDD:290200	9/27 (33%)
		C2H2 Zn finger	527..547	CDD:275368	6/19 (32%)
		C2H2 Zn finger	555..575	CDD:275368	5/19 (26%)
		zf-H2C2_2	568..592	CDD:290200	5/23 (22%)
		C2H2 Zn finger	583..603	CDD:275368	4/19 (21%)
		zf-H2C2_2	596..619	CDD:290200	7/24 (29%)
		C2H2 Zn finger	611..631	CDD:275368	3/19 (16%)
		C2H2 Zn finger	639..659	CDD:275368	3/19 (16%)
		C2H2 Zn finger	667..687	CDD:275368	2/19 (11%)
		COG5048	691..1133	CDD:227381	74/398 (19%)
		C2H2 Zn finger	695..715	CDD:275368	6/20 (30%)
		zf-H2C2_2	707..732	CDD:290200	11/27 (41%)
		C2H2 Zn finger	723..743	CDD:275368	7/19 (37%)
		C2H2 Zn finger	751..771	CDD:275368	1/19 (5%)
		zf-H2C2_2	764..788	CDD:290200	5/27 (19%)
		C2H2 Zn finger	779..799	CDD:275368	3/23 (13%)
		C2H2 Zn finger	807..827	CDD:275368	3/19 (16%)
		C2H2 Zn finger	835..855	CDD:275368	3/31 (10%)
		C2H2 Zn finger	863..883	CDD:275368	6/30 (20%)
		zf-H2C2_2	876..899	CDD:290200	6/33 (18%)
		C2H2 Zn finger	891..911	CDD:275368	2/19 (11%)
		C2H2 Zn finger	919..939	CDD:275368	6/20 (30%)
		C2H2 Zn finger	947..967	CDD:275368	4/19 (21%)
		C2H2 Zn finger	976..995	CDD:275368	2/18 (11%)
		C2H2 Zn finger	1003..1023	CDD:275368	6/20 (30%)
		zf-H2C2_2	1015..1039	CDD:290200	3/9 (33%)
		C2H2 Zn finger	1031..1051	CDD:275368
		C2H2 Zn finger	1059..1079	CDD:275368
		C2H2 Zn finger	1087..1107	CDD:275368
		zf-H2C2_2	1099..1124	CDD:290200
		C2H2 Zn finger	1115..1135	CDD:275368
		C2H2 Zn finger	1143..1163	CDD:275368
		C2H2 Zn finger	1171..1191	CDD:275368
		C2H2 Zn finger	1199..1219	CDD:275368
		zf-H2C2_2	1212..1236	CDD:290200
		C2H2 Zn finger	1227..1247	CDD:275368
		C2H2 Zn finger	1255..1275	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142422
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930