DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and ZNF184

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001305820.1	Gene:	ZNF184 / 7738	HGNCID:	12975	Length:	751	Species:	Homo sapiens

Alignment Length:	784	Identity:	153/784 - (19%)
Similarity:	259/784 - (33%)	Gaps:	220/784 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly    15 KEVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITHRSIPSSLPIKICFVCTSTFMSSAALIE 79
            |:|..|.  |.:..|.:..||: .|.|.:|  ||..||                   :.|..|
Human    31 KDVIVDF--TQEEWKQLDPGQR-DLFRDVT--LENYTH-------------------LVSIGL-- 69

  Fly    80 KVRETVDRVQEQPAKKTKVAEIE---EPSTQESDKKAVKVPKKNTTLRQRSKSIAAFPPSFVNGA 141
                       |.:|...::::|   ||...|............|.|   ..|::|..|..
Human    70 -----------QVSKPDVISQLEQGTEPWIMEPSIPVGTCADWETRL---ENSVSAPEPDI---- 116

  Fly   142 NTNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSVKL------------TPAKEVSSTKKAF-- 192
               :|.|:   ||:.:.:..|:..|  :..||.:|.:.            |..||:..|:|..
Human   117 ---SEEEL---SPEVIVEKHKRDDS--WSSNLLESWEYEGSLERQQANQQTLPKEIKVTEKTIPS 173

  Fly   193 ------LNLFGNGGNDAIEVLT-ESEEEEDSDKGPITINTN------NFQCPECEFHAKFPKPYK 244
                  .|.||...|.:..::| |...||.|.|..|..|:|      :.:|.||.....:.....
Human   174 WEKGPVNNEFGKSVNVSSNLVTQEPSPEETSTKRSIKQNSNPVKKEKSCKCNECGKAFSYCSALI 238

  Fly   245 EHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLR-DTHSRTFESEAKTKA-----KESKEKEAK 303
            .| |:.|..::|  |.|..|.|.|...:.|.||.| .|..:.::.:...|.     ..::.:...
Human   239 RH-QRTHTGEKP--YKCNECEKAFSRSENLINHQRIHTGDKPYKCDQCGKGFIEGPSLTQHQRIH 300

  Fly   304 SGAK-NKIDAKAKETNAVSQRKK-PKEKKSKEKKTEIKCNVETKVVDEIDDQVNNKK-------- 358
            :|.| .|.|...|   |.|||.. .:.::....:....||...|...:....:.::|
Human   301 TGEKPYKCDECGK---AFSQRTHLVQHQRIHTGEKPYTCNECGKAFSQRGHFMEHQKIHTGEKPF 362

  Fly   359 GTDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAIN--GSSASTP---------RAD 412
            ..|..|...|::|.:...:.::             ..|.|:..|  |.:.:.|         ...
Human   363 KCDECDKTFTRSTHLTQHQKIH-------------TGEKTYKCNECGKAFNGPSTFIRHHMIHTG 414

  Fly   413 SNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPN 477
            ...::|..|.........:.:|.|| |:.:||  :.|..|.||.:...||..|:.:|
Human   415 EKPYECNECGKAFSQHSNLTQHQKT-HTGEKP--YDCAECGKSFSYWSSLAQHLKIH-------- 468

  Fly   478 SSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFK 542
                                    |.||.....:..::.:..:..|..:.:...::..|..:..|
Human   469 ------------------------TGEKPYKCNECGKAFSYCSSLTQHRRIHTREKPFECSECGK 509

  Fly   543 TDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKR 607
            ..:...              |..|||                ||            ::..|:.:.
Human   510 AFSYLS--------------NLNQHQ----------------KT------------HTQEKAYEC 532

  Fly   608 KKQDKSEDTLPSSDVDIVEEINYNVRP---HKKARLESIGDST-------ADESTLSCDRCGKFV 662
            |:..|:  .:.||.:...|.|:...:|   |:..:..|.|.|.       ..|....|:.||:..
Human   533 KECGKA--FIRSSSLAKHERIHTGEKPYQCHECGKTFSYGSSLIQHRKIHTGERPYKCNECGRAF 595

  Fly   663 KSRQRLDSHMEKKHAAK-LQCTLCKEVYQNQMDYVAHFSNCGSEGGLPCGVANCKKVFTEANFLS 726
            .....|..|......|| .:|..|.:.:::......|......|....|.  .|:|.|::::.|:
Human   596 NQNIHLTQHKRIHTGAKPYECAECGKAFRHCSSLAQHQKTHTEEKPYQCN--KCEKTFSQSSHLT 658

  Fly   727 SHLR 730
            .|.|
Human   659 QHQR 662

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/20 (25%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	7/19 (37%)
ZNF184	NP_001305820.1	KRAB	28..88	CDD:214630	21/93 (23%)
		KRAB	28..67	CDD:279668	14/59 (24%)
		Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	191..212		7/20 (35%)
		C2H2 Zn finger	224..244	CDD:275368	5/20 (25%)
		zf-H2C2_2	236..261	CDD:290200	9/27 (33%)
		COG5048	<248..409	CDD:227381	34/178 (19%)
		C2H2 Zn finger	252..272	CDD:275368	8/19 (42%)
		zf-H2C2_2	264..287	CDD:290200	6/22 (27%)
		C2H2 Zn finger	280..300	CDD:275368	1/19 (5%)
		zf-H2C2_2	292..317	CDD:290200	6/27 (22%)
		C2H2 Zn finger	308..328	CDD:275368	6/22 (27%)
		zf-H2C2_2	320..345	CDD:290200	3/24 (13%)
		C2H2 Zn finger	336..356	CDD:275368	4/19 (21%)
		zf-H2C2_2	348..373	CDD:290200	3/24 (13%)
		COG5048	360..736	CDD:227381	68/397 (17%)
		C2H2 Zn finger	364..384	CDD:275368	4/19 (21%)
		zf-H2C2_2	376..400	CDD:290200	4/36 (11%)
		C2H2 Zn finger	392..412	CDD:275368	3/19 (16%)
		zf-C2H2	418..440	CDD:278523	5/22 (23%)
		C2H2 Zn finger	420..440	CDD:275368	5/20 (25%)
		zf-H2C2_2	432..457	CDD:290200	10/27 (37%)
		C2H2 Zn finger	448..468	CDD:275368	7/19 (37%)
		zf-H2C2_2	460..485	CDD:290200	7/56 (13%)
		C2H2 Zn finger	476..496	CDD:275368	1/19 (5%)
		zf-H2C2_2	488..513	CDD:290200	3/24 (13%)
		C2H2 Zn finger	504..524	CDD:275368	7/61 (11%)
		zf-H2C2_2	516..541	CDD:290200	9/54 (17%)
		C2H2 Zn finger	532..552	CDD:275368	5/21 (24%)
		zf-H2C2_2	544..569	CDD:290200	4/24 (17%)
		C2H2 Zn finger	560..580	CDD:275368	4/19 (21%)
		zf-H2C2_2	572..597	CDD:290200	5/24 (21%)
		C2H2 Zn finger	588..608	CDD:275368	5/19 (26%)
		zf-H2C2_2	600..625	CDD:290200	6/24 (25%)
		C2H2 Zn finger	616..636	CDD:275368	3/19 (16%)
		zf-H2C2_2	628..653	CDD:290200	6/26 (23%)
		C2H2 Zn finger	644..664	CDD:275368	7/21 (33%)
		zf-H2C2_2	656..681	CDD:290200	3/7 (43%)
		C2H2 Zn finger	672..692	CDD:275368
		zf-H2C2_2	684..709	CDD:290200
		C2H2 Zn finger	700..720	CDD:275368
		C2H2 Zn finger	728..748	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142337
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930