DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and ZNF747

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001291947.1	Gene:	ZNF747 / 65988	HGNCID:	28350	Length:	331	Species:	Homo sapiens

Alignment Length:	164	Identity:	42/164 - (25%)
Similarity:	59/164 - (35%)	Gaps:	34/164 - (20%)

- Green bases have known domain annotations that are detailed below.

  Fly   333 EKKTEI-----------KCNVETKVVDEID-DQVNNKKGTDS-EDADQTQA------TKIASFKA 378
            |:|.|:           ||..|....|..: ::...::||.: |..|...|      ...|.|..
Human    90 EEKAELWDPAAQDPEVAKCPTEADPADSRNKEEERQREGTGALEKPDPVAAGSPGLKAPQAPFAG 154

  Fly   379 LNESLMKKRMLENVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSIDK 443
            | |.|.|.|.     .|...|.   :....||||..: .|.:|.........:.||:.: |..:|
Human   155 L-EQLSKARR-----RSRPRFF---AHPPVPRADQRH-GCYVCGKSFAWRSTLVEHIYS-HRGEK 208

  Fly   444 PKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPN 477
            |  |.|..|.|......||..|..:|.  .|.|:
Human   209 P--FHCADCGKGFGHASSLSKHRAIHR--GERPH 238

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	4/20 (20%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	6/19 (32%)
ZNF747	NP_001291947.1	Disordered. /evidence=ECO:0000256\|SAM:MobiDB-lite	1..32
		KRAB	37..96	CDD:214630	3/5 (60%)
		KRAB	37..76	CDD:279668
		C2H2 Zn finger	184..204	CDD:275368	4/20 (20%)
		zf-H2C2_2	197..219	CDD:290200	9/24 (38%)
		C2H2 Zn finger	212..232	CDD:275368	6/19 (32%)
		zf-H2C2_2	224..247	CDD:290200	6/17 (35%)
		COG5048	236..>273	CDD:227381	1/3 (33%)
		C2H2 Zn finger	240..260	CDD:275368
		zf-H2C2_2	252..275	CDD:290200
		C2H2 Zn finger	268..288	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142305
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930