DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2199 and ZNF302

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_016882467.1	Gene:	ZNF302 / 55900	HGNCID:	13848	Length:	444	Species:	Homo sapiens

Alignment Length:	393	Identity:	69/393 - (17%)
Similarity:	123/393 - (31%)	Gaps:	162/393 - (41%)

- Green bases have known domain annotations that are detailed below.

  Fly   162 KKQISRLFEDNLNDSVKLTPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPITI--- 223
            :|::|:.:|....:       ||:|:.|..:                    :|||.: |:|:
Human   111 EKKLSKDWESRWEN-------KELSTKKDIY--------------------DEDSPQ-PVTMEKV 147

  Fly   224 --------NTN-NFQCPECE-----FHAK--FPKP--------------YKEHLQKEHGLQ---- 254
                    |:| |.:..||:     ||:|  ..:|              .|::|.|:..::
Human   148 VKQSYEFSNSNKNLEYTECDTFRSTFHSKSTLSEPQNNSAEGNSHKYDILKKNLSKKSVIKSERI 212

  Fly   255 -----------------------------RPRIYPCTLCIKTFGVLKTLKNHLR-DTHSRTFESE 289
                                         |.:||.|:.|.|.||....|..|.| .|..:.:|..
Human   213 NGGKKLLNSNKSGAAFNQSKSLTLPQTCNREKIYTCSECGKAFGKQSILSRHWRIHTGEKPYECR 277

  Fly   290 --AKTKAKES---KEKEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDE 349
              .||.:..|   :.:.:.||                  :||           .|| :|......
Human   278 ECGKTFSHGSSLTRHQISHSG------------------EKP-----------YKC-IECGKAFS 312

  Fly   350 IDDQVNNKKGTDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSASTPRADSN 414
            ....:.|.:.|.:.:..........||..::..:...|:                     .....
Human   313 HGSSLTNHQSTHTGEKPYECMNCGKSFSRVSLLIQHLRI---------------------HTQEK 356

  Fly   415 NFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPNSS 479
            .::|.||....:.:..:..|.|: |:.:||  ::|..|.|:......|..|..:|        |.
Human   357 RYECRICGKAFIHSSSLIHHQKS-HTGEKP--YECRECGKAFCCSSHLTQHQRIH--------SM 410

  Fly   480 KRK 482
            |:|
Human   411 KKK 413

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/20 (25%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/19 (26%)
ZNF302	XP_016882467.1	KRAB	48..109	CDD:214630
		COG5048	<151..393	CDD:227381	50/295 (17%)
		C2H2 Zn finger	248..268	CDD:275368	8/19 (42%)
		C2H2 Zn finger	276..296	CDD:275368	3/19 (16%)
		C2H2 Zn finger	304..324	CDD:275368	3/20 (15%)
		C2H2 Zn finger	332..352	CDD:275368	3/40 (8%)
		C2H2 Zn finger	360..380	CDD:275368	5/20 (25%)
		C2H2 Zn finger	388..408	CDD:275368	5/19 (26%)
		C2H2 Zn finger	416..436	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142434
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930