DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2199 and ZNF107

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001374954.1	Gene:	ZNF107 / 51427	HGNCID:	12887	Length:	896	Species:	Homo sapiens

Alignment Length:	777	Identity:	157/777 - (20%)
Similarity:	245/777 - (31%)	Gaps:	212/777 - (27%)

- Green bases have known domain annotations that are detailed below.

  Fly     4 ILLCENMTKVQKEVRCDHCGTSQGSKSVFSGQKVFLGRKITD---VLETIT-HRSIPSSLPIKIC 64
            |..|....||     .|....|...|...:|.|.|..::.:.   ||..:| ||.|.:.:....|
Human   188 IFQCNKYVKV-----FDKFSNSNRYKRRHTGNKHFKCKECSKSFCVLSQLTQHRRIHTRVNSYKC 247

  Fly    65 FVCTSTFMSSAALIEKVRETVDRVQEQPAKKTKVAEIEEPSTQESDKKAVKVPKKNTTLRQRSKS 129
            ..|...|...:.|.:..|   ....|:|.|..:..:....|:|.:..|.:...:|.....:..|:
Human   248 EECGKAFNWFSTLTKHKR---IHTGEKPYKCEECGKAFNQSSQLTRHKIIHTEEKPNKCEECGKA 309

  Fly   130 IAAFPPSFVNGANTNTEIEII--SASPKKLDKTPK--KQISRLFEDN-LNDSVKLTPAKEVSSTK 189
            .        ..|:..|..:||  ...|.|.::..|  .|.|.|.... |:....|...||..
Human   310 F--------KQASHLTIHKIIHTGEKPYKYEECGKVFSQSSHLTTQKILHTGENLYKCKECG--- 363

  Fly   190 KAFLNLFGNGGND-----------------AIEVLTESEEEEDSDKGPITINTNNFQCPECEFHA 237
            ||| |||.|..|.                 |..:.:...::|....|. .:|    :|.||:  .
Human   364 KAF-NLFSNLTNHKRIHAGEKPYKCKECGRAFNISSNLNKQEKIHTGG-KLN----KCEECD--K 420

  Fly   238 KFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLRDTHSRTFESEAKTKAKESKEKEA 302
            .|.:..|....|:. |...:.|.|..|.|.|....||..| :..|:    .|...|.||.
Human   421 AFNRSLKLTAHKKI-LMEEKPYKCEECGKVFNQFSTLTRH-KIIHT----GEKPYKCKEC----- 474

  Fly   303 KSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDDQVNNKKGTDSEDADQ 367
                       .|..|..|...:.|:..:.||  ..||....|..::..:.:|::|....|...:
Human   475 -----------GKAFNQSSNLTEHKKIHTAEK--SYKCEECGKAFNQHSNLINHRKIYSGEKPYK 526

  Fly   368 TQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSASTP----RADSNNFQCEICDCELMTA 428
            .:                          |...|.|.||..|.    ......::||.||.....:
Human   527 CE--------------------------ECGKAFNRSSTLTRHKKIHTGEKPYKCEECDRAFSQS 565

  Fly   429 KQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPNSSKRKILQDEDEDVDI 493
            ..:.|| |.:|:.:||  :||..|.|:.....:|..|..:|
Human   566 SNLTEH-KKIHTGEKP--YKCEECGKAFNRFSTLTKHKRIH------------------------ 603

  Fly   494 LGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKI 558
                    |.||....::..::..::.:.|..||:..::::          |..|:.
Human   604 --------TGEKPYKCEECGKAFNQSYQLTRHKIVHTKEKL----------NKCEEF-------- 642

  Fly   559 IRSRNNIQHQVDGGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVD 623
                                 .|..|::||..:......|..|.|.|:..|.......|.:..:.
Human   643 ---------------------GKAFKQSSHRTIHKIIHTGEKPYKCEEHGKVFNQSSNLTTQKII 686

  Fly   624 IVEEINYNVRPHKKARLESIGDST------ADESTLSCDRCGKFVKSRQRLDSHMEKKHAAK--L 680
            ...|..|....|.|| .....:.|      ..|....|:.|||.......|..| ::.|..:  .
Human   687 HTGENLYKFEEHGKA-FNLFSNITNHKIIYTGEKPHKCEECGKAYNRFSNLTIH-KRIHTGEKPY 749

  Fly   681 QCTLCKEVYQNQMDYVAHFSNCGS---------EGGLPCGVANCKKVFTEANFLSSHLRKRH 733
            ||..|.:.:           ||.|         .|..|.....|.|.|..::.|::| :|.|
Human   750 QCAECGKAF-----------NCSSTLNRHKIIHTGEKPYKCKECGKAFNLSSTLTAH-KKIH 799

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	7/20 (35%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/19 (26%)
ZNF107	NP_001374954.1	KRAB	48..108	CDD:214630
		C2H2 Zn finger	191..211	CDD:275368	6/24 (25%)
		C2H2 Zn finger	219..239	CDD:275368	5/19 (26%)
		COG5048	243..621	CDD:227381	97/484 (20%)
		C2H2 Zn finger	247..267	CDD:275368	5/22 (23%)
		C2H2 Zn finger	275..295	CDD:275368	3/19 (16%)
		C2H2 Zn finger	303..323	CDD:275368	4/27 (15%)
		C2H2 Zn finger	331..351	CDD:275368	4/19 (21%)
		C2H2 Zn finger	359..379	CDD:275368	10/23 (43%)
		C2H2 Zn finger	387..407	CDD:275368	2/19 (11%)
		C2H2 Zn finger	415..435	CDD:275368	6/22 (27%)
		C2H2 Zn finger	443..463	CDD:275368	7/20 (35%)
		C2H2 Zn finger	471..491	CDD:275368	6/35 (17%)
		C2H2 Zn finger	499..519	CDD:275368	4/19 (21%)
		C2H2 Zn finger	527..547	CDD:275368	6/45 (13%)
		COG5048	551..>863	CDD:227381	64/337 (19%)
		C2H2 Zn finger	555..575	CDD:275368	7/20 (35%)
		C2H2 Zn finger	583..603	CDD:275368	5/19 (26%)
		C2H2 Zn finger	611..631	CDD:275368	3/19 (16%)
		C2H2 Zn finger	639..659	CDD:275368	5/48 (10%)
		C2H2 Zn finger	699..715	CDD:275368	3/16 (19%)
		C2H2 Zn finger	723..743	CDD:275368	6/20 (30%)
		C2H2 Zn finger	751..771	CDD:275368	5/30 (17%)
		C2H2 Zn finger	779..799	CDD:275368	6/20 (30%)
		C2H2 Zn finger	807..827	CDD:275368
		C2H2 Zn finger	835..855	CDD:275368
		C2H2 Zn finger	863..883	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142208
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930