DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and CG12942

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_610628.2	Gene:	CG12942 / 36158	FlyBaseID:	FBgn0033569	Length:	686	Species:	Drosophila melanogaster

Alignment Length:	672	Identity:	134/672 - (19%)
Similarity:	226/672 - (33%)	Gaps:	193/672 - (28%)

- Green bases have known domain annotations that are detailed below.

  Fly   110 DKKAV----KVP--KKNTTLRQRSKSIAAFPPSFVNGANTNTEIEIISAS----PKKLD------ 158
            |:|.|    :||  :|..|..|..|..            ||.::.:||..    |.::.
  Fly    29 DRKTVQLNAEVPNLQKTRTYAQSLKQC------------TNLDLRVISPGGYLWPMQICVRCCRA 81

  Fly   159 -KTPKKQISRLFEDNLN-----DSVKL-TPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDS 216
             :.....:....|.||.     .|||| :|..|:.  :||                  |.|
  Fly    82 LEVAMHFVEMALESNLKLQAEAKSVKLPSPTGELK--RKA------------------SNE---- 122

  Fly   217 DKGPITINTNNFQCPECEFHAKFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLRDT 281
                 ||..|.|.....:|...:..|.:|::....|.:.||:          .|..:..:.....
  Fly   123 -----TIPWNQFSQEFEQFVEGYEGPIEENVLYMRGTKVPRL----------DVDASSSSETAPK 172

  Fly   282 HSRTFESEAKTKAKESKEKEAKSGAKNKIDAKAKET---NAVSQRKKPKEKKSKEKKTEIKCNVE 343
            .......:.|....:.:|::...|:    |||..||   |:::..:........||..|...|.
  Fly   173 EDEVILFDVKYDTNDLEEEDENDGS----DAKNNETFFENSITPGESVMVVSVAEKAVENNNNY- 232

  Fly   344 TKVVDEIDDQVNNKKG--TDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSA 406
                     ..|||.|  || |:.|..|                 |.||..::.:      |.|.
  Fly   233 ---------NFNNKNGDVTD-EECDLIQ-----------------RALEMTLNDD------GCSQ 264

  Fly   407 STPRADSNNFQCEICDCELMTAK--QMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLH 469
            |.....||..|.:....|:.:..  ::.....|..:|   .:.||::|:.:....:.||.|.
  Fly   265 SPKNEASNETQLKSNGIEVSSPLFIKLATTSSTTGNI---PILKCNICQYTHTDAEQLKIHY--- 323

  Fly   470 ADGAEAPNSSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEV 534
                    .|..||...||   ||:|..:.:|          .:..|..:.:..:|..:|:
  Fly   324 --------KSIHKISMMED---DIIGLNKNQN----------FKCRPCNSYETKDRSEMQK---- 363

  Fly   535 VEIVDAFKTDNTAE-----DDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKK-TKKTSHVDLSV 593
             .::|..|.|...|     ....||.::|.:.:              ||..|. |:..:.|.::|
  Fly   364 -HLIDHHKIDGDFEMYCYMQANCPACDRIFKDQ--------------RSARKHYTRVHTPVQIAV 413

  Fly   594 STTNG----------NSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTA 648
            |.|..          |..|.....::..:.:|.:..|..|  ::.| ::|.: :..|:.:   .|
  Fly   414 SPTESYACTACDKVFNQKASLHSHQRFCQVKDVVHCSFCD--QQFN-SMRKY-ELHLQQL---HA 471

  Fly   649 DESTLSCDRCGKFVKSRQRLDSHMEKKHAAKLQCTLCKEVYQNQMDYVAHF--SNCGSEGGLPCG 711
            .|:...|:.|.:..||.:.|..|.::......||..|...|.|..:...|:  ::...|   |..
  Fly   472 VETVHECEICRRSFKSAETLTMHRKRHSERHYQCGKCSLNYVNSAELRVHYERAHVNEE---PVS 533

  Fly   712 VANCKKVFTEANFLSSHLRKRH 733
            ...|...|.....|..|.::.|
  Fly   534 CLTCGNQFQNMTLLREHEQRSH 555

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	2/22 (9%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/19 (26%)
CG12942	NP_610628.2	zf-AD	22..101	CDD:285071	17/83 (20%)
		C2H2 Zn finger	385..406	CDD:275368	7/34 (21%)
		C2H2 Zn finger	421..470	CDD:275368	8/55 (15%)
		C2H2 Zn finger	449..466	CDD:275371	4/20 (20%)
		C2H2 Zn finger	478..498	CDD:275368	6/19 (32%)
		C2H2 Zn finger	505..526	CDD:275368	5/20 (25%)
		C2H2 Zn finger	534..555	CDD:275368	4/20 (20%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440078
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930