DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and CG18011

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_610559.1	Gene:	CG18011 / 36068	FlyBaseID:	FBgn0033491	Length:	985	Species:	Drosophila melanogaster

Alignment Length:	969	Identity:	179/969 - (18%)
Similarity:	303/969 - (31%)	Gaps:	329/969 - (33%)

- Green bases have known domain annotations that are detailed below.

  Fly    10 MTKVQKEVRCDHCGTSQGSKSVFSG----QKVFLGRKITDVLETITHRSIP---SSLPIK---IC 64
            |::..|...|.||       ||||.    |::|....|...|:::..|...   |..|.|   :|
  Fly     1 MSENAKNNSCLHC-------SVFSTKYQYQEIFDEFGIELGLQSLLSRHYQLEVSPDPQKQQLLC 58

  Fly    65 FVCTSTFMSSAAL--IEKVRETV-DRVQEQPAKKTK----VAEIE-EPSTQESDKKAVK------ 115
            .||.:..:....:  :|:.||.. |..|.:.:|..:    :.|:: .|...:..||.|.
  Fly    59 EVCVTNLIRLFDIDELEREREAAKDAAQGKDSKAEEDPIIITEVQATPPAAKPAKKTVPSRPLTK 123

  Fly   116 -------VPKKNTTLRQRSKSIAAF-----------PPSFVNGANTNTEIEIISASPKKLDKTPK 162
                   :|.:..:.|.|:::.||.           ||.     ..:||..:..:.||.:.|...
  Fly   124 VLRPVPIIPTREPSARIRNRAAAASNVTPDTSRSPEPPE-----TPSTEDAVSKSEPKLVSKVAD 183

  Fly   163 KQISRLFEDNLNDSVKL-----TPAKEVSS-----TKK-------AFLN---------------- 194
            ::...:...|:.|..:.     |..||.||     |::       ..||
  Fly   184 QEHFSVLIQNILDEEEAVVEDETAVKEESSEAVQVTEETEAPGQIVILNSEAVTDTNPDENVYIY 248

  Fly   195 -----LFGNGGNDAIEVLT----------ESEEEEDSDKGP------------------------ 220
                 :..|..|..::.::          ||:.::|.|:|.
  Fly   249 EHEDVMDPNLDNVKVKPISCSSRLVAQAEESQSDDDIDEGETSNVVLFNFVDIKEKDEVDNIPEY 313

  Fly   221 -ITINTNNFQ------CPECEFHAKFPKPYKE----HLQKEHGLQRPRIYPCTL--CIKTFGVLK 272
             .|:...:|:      |..|: |.....|..|    ||.|.|..:|. :|.|.:  |.|.....|
  Fly   314 LATVVKTSFEKLTFQWCTVCK-HCSLKCPTFESLFSHLSKAHKSRRD-VYECPIEGCNKELKGRK 376

  Fly   273 TLKNHLRDTHSRTFESEAKTKAKESK---------EKEA-------KSGAKNKIDAKA------K 315
            .|..||...|:...|........|.|         .|.:       |.|.::..:..:      |
  Fly   377 FLAMHLVLLHAPVAEIPIYGSCPECKLTFSNILQYNKHSCAHVIKKKRGFRSYCEMCSLEFPSWK 441

  Fly   316 ETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDDQVN---NKKGTDSED-ADQTQATKIASF 376
            ..|..||....|.:    .:....|:..|..:||:...:|   ...||...| .|:|       |
  Fly   442 RFNFHSQFHLEKHR----PRACFVCDYATTNIDELFQHLNYSHEPVGTLFCDLCDRT-------F 495

  Fly   377 KALNESLMKKRMLENVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSI 441
            :                |.......|.|.|:   ..|..:.|..|.....:..::..||:.:|.
  Fly   496 R----------------DPSVFMEHNKSHAN---VSSTTYSCSECMANFESRGRLNGHMRAMHG- 540

  Fly   442 DKPKVFKCHVCEKSLATKQSLKTHMTLH----------------ADGAEA----PNSSK-----R 481
               .|..|.:|.:..||:.:...||..|                :|..|.    .||.|     .
  Fly   541 ---SVISCELCSREFATEATYNIHMKKHLIIEKDVHVCSTCGLLSDSRETLLAHVNSVKTACFGS 602

  Fly   482 KILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAA--------------KFTNRKILQEED 532
            ||      ||::|....:..........|...|:...:.              :|.:.|:.:..
  Fly   603 KI------DVELLRDAYVCEYCSSYFKEKDCLQAHRDSGVHKDGVFLCQPCGKEFPHMKLYRHH- 660

  Fly   533 EVVEIVDAFKTDNTAED---------DEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTSH 588
              :......::|:|...         |:....|..:...:...|                |:.:|
  Fly   661 --LRNYQQLRSDSTHRRLEICVYYMCDQENCTESYVNWNSLYTH----------------KRRTH 707

  Fly   589 VDLSVSTTNGNSPAK--------SEKRKKQDKSEDTLPSSDVDIV--EEINYNVRPHKKARLESI 643
            ...|......:..|:        .|.|.|...|.....|.:.|.|  ...|.:.:.|
  Fly   708 ESASKQAEKSSKSAQEWVCQFCLKECRSKMSLSVHVARSHNNDNVTCPLCNSSYKSH-------- 764

  Fly   644 GDSTAD-----ESTLSCDRCGKFVKSRQRLDSHMEKKHAAK--LQCTLCKEVYQNQMDYVAH--- 698
             |:.|.     ...:.|..|.|.||:|:..|:|:...|:.|  ..|::|::.:.::.:..||
  Fly   765 -DALAKHHAYWHEPIECPECFKIVKNRRNYDTHVNVVHSNKKRYSCSVCQKGFYHKSEMEAHQKL 828

  Fly   699 -----------FSNCGSEG-------------GLPCGVANCKKVFTEANFLSSHLRKRH 733
                       |:....:.             ...|.|  |||.|..:..|.:|:::.|
  Fly   829 HGQSYSCEQCSFTTRNKKSLSVHVLGQHYKRFAFECNV--CKKRFGRSQGLKTHMQRAH 885

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	4/20 (20%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	6/19 (32%)
CG18011	NP_610559.1	PRK14950	<98..>184	CDD:237864	17/90 (19%)
		C2H2 Zn finger	488..508	CDD:275368	6/42 (14%)
		C2H2 Zn finger	518..538	CDD:275368	4/19 (21%)
		C2H2 Zn finger	545..565	CDD:275368	6/19 (32%)
		C2H2 Zn finger	575..596	CDD:275371	4/20 (20%)
		SFP1	<682..747	CDD:227516	11/80 (14%)
		C2H2 Zn finger	754..775	CDD:275368	4/29 (14%)
		C2H2 Zn finger	780..801	CDD:275368	8/20 (40%)
		C2H2 Zn finger	809..829	CDD:275368	4/19 (21%)
		C2H2 Zn finger	864..885	CDD:275368	8/22 (36%)
		C2H2 Zn finger	891..917	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45440079
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930