DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and az2

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_610289.2	Gene:	az2 / 35682	FlyBaseID:	FBgn0025185	Length:	593	Species:	Drosophila melanogaster

Alignment Length:	715	Identity:	118/715 - (16%)
Similarity:	214/715 - (29%)	Gaps:	249/715 - (34%)

- Green bases have known domain annotations that are detailed below.

  Fly    68 TSTFMSSAALIEKVRETVDRVQEQPA-------------------KKTKVAEIEEPSTQESDKKA 113
            ||..:|||...|:|......:.|:|.                   :.|...|.||....|.|..:
  Fly    58 TSEVISSAKCEEEVSPAKVFIVEEPPENCLAEDMFVDVPPSSENDESTSPVEEEEEEDDEVDSSS 122

  Fly   114 VKVP----KKNTTLRQRSKSIAAFPPSFVNGANTNTE-IEIISASPKKLDKTPKKQISRLFEDNL 173
            :.|.    .:|:|   ....:..|.|:|...:...|: ||:.            ||.:.|::
  Fly   123 MTVDCELGTRNST---HFAPLTKFNPTFYRRSPRITQFIELY------------KQQTCLWD--- 169

  Fly   174 NDSVKLTPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPITINTNNFQCPEC--EFH 236
                   ||.|....|:...|.:              ||..:..|..:.::...::..:|  ..|
  Fly   170 -------PADESYRDKEKRANAY--------------EELLEQLKATVNLHLTAYKLKKCITSLH 213

  Fly   237 AKFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTL--KNHLRDTHSRTFESEAKTKAKESKE 299
            |::....::  :|...|.:..:|       ..|....|  :..|.|..|...:.:.|.|...::|
  Fly   214 AQYASISRQ--KKTQKLTKVPLY-------YHGKYSFLAERGSLEDADSDDVDGDGKIKLVFTEE 269

  Fly   300 KEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETK------VVDEIDDQVNNKK 358
            .:..:   ..||..:|    ..|...|..|..        ||:..:      :.|.:..:.:...
  Fly   270 NQLTT---QFIDLYSK----FPQLYDPAHKHF--------CNLNVRKSSLIEITDLLTSEFSLGL 319

  Fly   359 GTDSEDADQTQATK---------IASFKALNESLMKKRMLENVIDSEYTFAINGSSASTPRADSN 414
            .|..:..|..|:.:         :...:.:..||.:|:.:|..           :|....::...
  Fly   320 VTHYDVYDSIQSMRQWYSRRIKTLTDVQCVGLSLAEKQYIERC-----------NSFMPTKSFRQ 373

  Fly   415 NFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPNSS 479
            ..:||:|:....|...:|.|....|.:.....|:|.:||.:...|..|:.|
  Fly   374 KLKCEVCEHSFSTDHALQAHQFRDHKMGDGGWFRCTLCELNFDRKCHLQQH-------------- 424

  Fly   480 KRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVD-AFKT 543
                                                        ::::..::..|.||.. :|..
  Fly   425 --------------------------------------------SQRVHMDKSFVCEICSRSFAF 445

  Fly   544 DNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAP---RSPAKKTKKTSHVDLSVSTTNGNSPAKSE 605
            .|          :..|..|.:.:..|....:..   :...:|.:.|:||
  Fly   446 GN----------QLAIHKRTHDEKHVAKPFVCEFCGKCFKQKIQMTTHV---------------- 484

  Fly   606 KRKKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTADESTLSCDRCGKFVKSRQRLDS 670
                                      ...|.|.|            ...||.|.|...:::.|..
  Fly   485 --------------------------TAVHTKIR------------AFKCDMCPKDFLTKRDLKD 511

  Fly   671 HMEKKH--AAKLQCTLCKEVYQNQMDYVAHFSNCGSEGGLPCGVANCKKVFTEANFLSSHLRKRH 733
            |: |.|  .....|.:|::.:.|....|.| .:...|..|.|.:  |...|:|...|..|:|:.|
  Fly   512 HV-KAHLNIRDKVCEVCQKAFTNANALVKH-RHIHKEKTLQCSL--CTTRFSERVSLGVHMRRTH 572

Fly 734 733
Fly 573 572

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	6/20 (30%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	6/19 (32%)
az2	NP_610289.2	MADF_DNA_bdg	157..242	CDD:287510	20/129 (16%)
		GT1	276..>341	CDD:304916	12/76 (16%)
		C2H2 Zn finger	377..398	CDD:275368	6/20 (30%)
		C2H2 Zn finger	408..429	CDD:275368	6/78 (8%)
		C2H2 Zn finger	436..456	CDD:275368	6/29 (21%)
		C2H2 Zn finger	467..488	CDD:275368	4/62 (6%)
		C2H2 Zn finger	496..516	CDD:275368	7/20 (35%)
		C2H2 Zn finger	524..544	CDD:275368	5/20 (25%)
		C2H2 Zn finger	551..572	CDD:275368	7/22 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C45457885
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.930