DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and CG12299

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_609448.1	Gene:	CG12299 / 34483	FlyBaseID:	FBgn0032295	Length:	736	Species:	Drosophila melanogaster

Alignment Length:	753	Identity:	146/753 - (19%)
Similarity:	253/753 - (33%)	Gaps:	229/753 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly    64 CFVCTSTFMSSAALIEKVRE-------TVDRVQEQPAKKTK--------VAEIEEPSTQESDKKA 113
            |..|...|:...||.:.:..       ...:.||.|..:::        |.|:.|..:..||..|
  Fly    50 CMCCAEFFVHPLALYQHMNTLHPHEPGNGQQEQESPGDESEDYSWIFEPVCELAEDGSDSSDGSA 114

  Fly   114 VK------------------VPKKNTTLRQRSKSIAAFPPSFVNGANTNTEIEIISASPK----- 155
            ..                  ....:::....|.|.::.|.:    :|:||:....|..|.
  Fly   115 SSGSDSSSSSDDDDDDDDDDSSSSSSSSSNSSSSSSSVPTT----SNSNTQQSQESVQPLHGLVA 175

  Fly   156 -------KLDKTPKKQISRLFEDNLNDSVKLTPAKEV---SSTKKAFLNL--------FGNGGND 202
                   :|..|..::.:.:|  .:..:|.:||.:::   :.|....|.|        .|...|.
  Fly   176 GPGYNEFQLQMTDPRESTSIF--MVQPTVSVTPLQQLLPPAPTVSPGLGLQSTPIKRRRGRRSNI 238

  Fly   203 AIEVLTESEEEEDSDKGPITINTNN--FQCPECEFHAKFPK--PYKEHLQKEHGLQRPRIYPCTL 263
            ...|:..:            :|.|.  |||..||  |.||.  ...:|: :.|...:|  :.|::
  Fly   239 GAPVMDPA------------LNGNQKCFQCTHCE--ASFPNAGDLSKHV-RSHITNKP--FQCSI 286

  Fly   264 CIKTFGVLKTLKNHLRDTHS--RTFESEAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKP 326
            |.|||..:.:|..|:| .||  :.::.|...||.............:.:             :||
  Fly   287 CQKTFTHIGSLNTHIR-IHSGEKPYKCELCPKAFTQSSSLMVHMRSHSV-------------RKP 337

  Fly   327 KEKKSKEK------------KTEIKCNVETKVVDEIDDQVNNKKGTDSEDADQTQ------ATKI 373
            .:....:|            ||.| ...||.:..|.:.:...:...|......||      |...
  Fly   338 HQCVQCDKGFINYSSLLLHQKTHI-APTETFICPECEREFKAEALLDEHMRMHTQELVYQCAICR 401

  Fly   374 ASFKALNESL--MKKRMLENVID---SEYTFAINGSSASTPRADSNN--FQCEICDCELMTAKQM 431
            .:|:|.:|.:  ||..|.|....   .:.:|..:||.....|..:..  |||::||.....|..:
  Fly   402 EAFRASSELVQHMKNHMGEKPFTCSLCDRSFTQSGSLNIHMRIHTGEKPFQCKLCDKCFTQASSL 466

  Fly   432 QEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLH--ADGAEAPNSSKRKILQDEDEDV--D 492
            ..||| :|:.:||  :.|.:|.||.:.:..|..|:..|  |..|.|..|....:.:...|.:  .
  Fly   467 SVHMK-IHAGEKP--YPCPICGKSYSQQAYLNKHIQAHQMASAASASTSPGLLVAKQPHETLVCI 528

  Fly   493 ILGTTQIENTA-------------------------------------------EKV-------- 506
            :.|:...:.||                                           |:|
  Fly   529 VCGSLHADATALASHVHSQHAALLDTMKQSGMNTAPGGAIPDVKCSAEEQQAYVERVQCVLQQMN 593

  Fly   507 ----------EGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFK---TDNTAEDDEGPAEEKI 558
                      :.|::.||.|.:    ..::.||::...:::....|   .|:|.||:|.|.|.:.
  Fly   594 HQQQHQQHQQQPPQQQQQHPQQ----QQQQHLQQQPHQMQLPQQPKLPAMDSTGEDEEEPDEAEE 654

  Fly   559 IRSRNNIQHQVDGGMIAPRSPAK-KTKKTSHVDLSVSTTNGNSPAKSEKRKK----QDKSEDTLP 618
            .......|.:       |..||: ||:..:..|   :.||...|....:.::    .|...:...
  Fly   655 PPDEEEEQDE-------PEEPAEVKTEVLAAED---ALTNPGYPILGLQEEQILLDSDMYYEDFG 709

  Fly   619 SSDVDIVEEINYNVRPHKKARLESIGDSTADESTLSCD 656
            ..||...||:              .||...:|..:..|
  Fly   710 DMDVGCQEEV--------------FGDFVVNEEEVYTD 733

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	7/20 (35%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	6/19 (32%)
CG12299	NP_609448.1	COG5048	<254..413	CDD:227381	40/178 (22%)
		C2H2 Zn finger	256..276	CDD:275368	7/22 (32%)
		zf-H2C2_2	268..293	CDD:290200	8/27 (30%)
		C2H2 Zn finger	284..304	CDD:275368	8/20 (40%)
		zf-H2C2_2	296..321	CDD:290200	8/25 (32%)
		zf-C2H2_2	312..>387	CDD:289522	13/88 (15%)
		C2H2 Zn finger	312..332	CDD:275368	3/19 (16%)
		C2H2 Zn finger	340..360	CDD:275368	2/19 (11%)
		C2H2 Zn finger	369..389	CDD:275368	2/19 (11%)
		C2H2 Zn finger	397..417	CDD:275368	6/19 (32%)
		zf-H2C2_2	409..434	CDD:290200	6/24 (25%)
		C2H2 Zn finger	425..445	CDD:275368	4/19 (21%)
		zf-H2C2_2	437..462	CDD:290200	7/24 (29%)
		C2H2 Zn finger	453..473	CDD:275368	7/20 (35%)
		zf-H2C2_2	465..490	CDD:290200	10/27 (37%)
		C2H2 Zn finger	481..501	CDD:275368	6/19 (32%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
	1	0.910