DRSC - DRSC Integrative Ortholog Prediction Tool

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Protein Alignment CG2199 and E430018J23Rik

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_932128.2	Gene:	E430018J23Rik / 101604	MGIID:	2141981	Length:	461	Species:	Mus musculus

Alignment Length:	406	Identity:	72/406 - (17%)
Similarity:	111/406 - (27%)	Gaps:	156/406 - (38%)

- Green bases have known domain annotations that are detailed below.

  Fly   340 CNVETKVVDEIDDQVNNKKGTDSEDADQTQAT-KIASFKA---------LNESLMKKRMLENVID 394
            |..|..     .|..:.|:|  ....::|:|| ||.|.:|         .:.|...:.:.:|...
Mouse    93 CRTEVH-----SDCRHEKEG--KRPREETKATKKILSPEAGPMEPRPSFASPSCNLELLFKNSQQ 150

  Fly   395 SEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATK 459
            ...|.|::....   :||..: .|.:|........::.||:.| |:.:||  |:|..|:|.....
Mouse   151 GHPTVAVHNPIL---KADQRH-GCHVCGKSFAHQSKLVEHLYT-HTGEKP--FQCPDCDKYFGRA 208

  Fly   460 QSLKTHMTLHADGAEAPNSSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTN 524
            .||..|..:|.  .|.|:                                    |.|.....||.
Mouse   209 SSLSMHRAIHR--GERPH------------------------------------QCPDCGKSFTQ 235

  Fly   525 RKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTSHV 589
            |..|                                    :.|
Mouse   236 RSTL------------------------------------VAH---------------------- 242

  Fly   590 DLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTADESTLS 654
               :.|..|..|.......|......:|.|.     ..|:...|||                  .
Mouse   243 ---MYTHTGEKPFHCPDCNKSFSRPSSLSSH-----RAIHRGERPH------------------C 281

  Fly   655 CDRCGKFVKSRQRLDSHM-----EKKHAAKLQCTLCKEVYQNQMDYVAHFSNCGSEGGLPCGVAN 714
            |..||:....|..|.:|:     ||.:.    |..|...: :|...:.........|..|....:
Mouse   282 CSDCGRAFTHRSGLIAHLRVHTGEKPYC----CADCGRCF-SQSSGLREHQRVVHSGVTPFTCTH 341

  Fly   715 CKKVFTEANFLSSHLR 730
            |.:.|..|.:|..|:|
Mouse   342 CGRAFARAAYLQCHMR 357

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/20 (25%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	6/19 (32%)
E430018J23Rik	NP_932128.2	KRAB	22..81	CDD:214630
		KRAB	22..61	CDD:279668
		C2H2 Zn finger	170..190	CDD:275368	5/20 (25%)
		zf-H2C2_2	183..207	CDD:290200	10/26 (38%)
		C2H2 Zn finger	198..218	CDD:275368	6/19 (32%)
		zf-H2C2_2	210..235	CDD:290200	9/62 (15%)
		COG5048	<223..383	CDD:227381	37/260 (14%)
		C2H2 Zn finger	226..246	CDD:275368	6/80 (8%)
		zf-H2C2_2	239..259	CDD:290200	5/80 (6%)
		C2H2 Zn finger	254..302	CDD:275368	13/70 (19%)
		zf-H2C2_2	298..319	CDD:290200	5/25 (20%)
		C2H2 Zn finger	310..331	CDD:275368	3/21 (14%)
		C2H2 Zn finger	339..359	CDD:275368	6/19 (32%)
		zf-H2C2_2	351..376	CDD:290200	3/7 (43%)
		C2H2 Zn finger	367..387	CDD:275368
		zf-H2C2_2	383..402	CDD:290200
		C2H2 Zn finger	395..415	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C167832248
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930