DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and LOC100365363

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	XP_006228060.2	Gene:	LOC100365363 / 100365363	RGDID:	2319215	Length:	670	Species:	Rattus norvegicus

Alignment Length:	623	Identity:	120/623 - (19%)
Similarity:	189/623 - (30%)	Gaps:	189/623 - (30%)

- Green bases have known domain annotations that are detailed below.

  Fly   175 DSVKLTPAKEVSSTKKAFLNLFGNGGNDAIEVLTESEEEEDSDKGPI-----------------T 222
            :::....||.:|           ||.:    :|:........||.|.                 .
  Rat    91 ENIDCMEAKSIS-----------NGSS----ILSSDRIFLSGDKAPFVHEYDVYSSLLMKGQKAA 140

  Fly   223 INTNNFQCPECEFHAKFPKPYKEHLQKEHGLQRPRIYPCTLCIKTFGVLKTLKNHLRDTHSRTFE 287
            |....:||.||:...::......|.|...|   .::|.|..|.|.|.....|..|.|. ||
  Rat   141 IKEKPYQCNECDKVFRYTSSLAYHRQIHTG---EKLYKCVECGKAFFRRSYLLVHERH-HS---- 197

  Fly   288 SEAKTKAKESKEKEAKSGAKNKIDAKAKETNAVSQRKKPKEKKSKEKKTEIKCNVETKVVDEIDD 352
                 .||..|..|.  |.....::..|....:...:||.:.....|...::.|:...:|....|
  Rat   198 -----GAKPYKCNEC--GKVFSQNSHLKSHRRIHTGEKPYKCNDCGKAFSVRSNLTHHLVIHTGD 255

  Fly   353 QVN--NKKGTDSEDADQTQATKIASFKALNESLMKKRMLENVIDSEYTFAINGSSASTPRA---D 412
            :..  |:.|   :...||.:..|.......|...:......|..|.       |:.:|.:|   .
  Rat   256 KPYKCNECG---KVFSQTSSLTIHRRTHTGEKPYRCNECGKVFSSH-------SNLNTHQAIHTG 310

  Fly   413 SNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKSLATKQSLKTHMTLHADGAEAPN 477
            ...::|..|.........:..|.:| |:.:||  :||:.|.|:.:...||.||:.:|
  Rat   311 EKPYKCSECGKVFTQNSHLANHWRT-HTGEKP--YKCNECGKAFSVYSSLTTHLAIH-------- 364

  Fly   478 SSKRKILQDEDEDVDILGTTQIENTAEKVEGPKKSQQSPTKAAKFTNRKILQEEDEVVEIVDAFK 542
                                    |.||   |.|.::.   ...||....|.....:......:|
  Rat   365 ------------------------TGEK---PYKCEEC---GKVFTQNSHLANHRGIHSGEKPYK 399

  Fly   543 TDNTAEDDEGPAEEKIIRSRNNIQHQVDGGMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKR 607
            .:..                                 .|...:||::........|..|.|..:.
  Rat   400 CEEC---------------------------------GKHFNQTSNLARHWRVHTGEKPYKCSEC 431

  Fly   608 KKQDKSEDTLPSSDVDIVEEINYNVRPHKKARLESIGDSTAD----------ESTLSCDRCGKFV 662
            .|......:|.|..|     |:...:|:|.|....:...|:.          |....|:.|||..
  Rat   432 GKAFSVRSSLTSHQV-----IHTGEKPYKCAECGKVFSQTSSLSIHQRIHTGEKPYRCNECGKAF 491

  Fly   663 KSRQRLDSHMEKKHAAK-LQCTLCKEVY-QNQMDYVAHFSN---------------CGS------ 704
            .|...|::|.......| .:|..|.:|: ||     :|.:|               ||.
  Rat   492 NSHSNLNTHQVIHTGQKPYKCLECGKVFTQN-----SHLANHHRTHTGEKPYKCNECGKAFSVYS 551

  Fly   705 ---------EGGLPCGVANCKKVFTEANFLSSHLRKRH 733
                     .|..|.....|.||||:.:.|:|| |:.|
  Rat   552 SLTTHQAIHTGEKPFKCNECGKVFTQNSHLASH-RRTH 588

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	4/20 (20%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	7/19 (37%)
LOC100365363	XP_006228060.2	KRAB	8..68	CDD:214630
		SFP1	<143..221	CDD:227516	23/92 (25%)
		C2H2 Zn finger	148..168	CDD:275368	5/19 (26%)
		C2H2 Zn finger	176..196	CDD:275368	7/20 (35%)
		COG5048	200..575	CDD:227381	84/470 (18%)
		C2H2 Zn finger	204..224	CDD:275368	3/21 (14%)
		C2H2 Zn finger	232..252	CDD:275368	3/19 (16%)
		C2H2 Zn finger	260..280	CDD:275368	5/22 (23%)
		C2H2 Zn finger	288..308	CDD:275368	5/26 (19%)
		C2H2 Zn finger	316..336	CDD:275368	4/20 (20%)
		C2H2 Zn finger	344..364	CDD:275368	7/19 (37%)
		C2H2 Zn finger	372..392	CDD:275368	3/22 (14%)
		C2H2 Zn finger	400..420	CDD:275368	3/52 (6%)
		C2H2 Zn finger	428..448	CDD:275368	4/24 (17%)
		C2H2 Zn finger	456..476	CDD:275368	2/19 (11%)
		C2H2 Zn finger	484..504	CDD:275368	7/19 (37%)
		C2H2 Zn finger	512..532	CDD:275368	7/24 (29%)
		C2H2 Zn finger	540..560	CDD:275368	2/19 (11%)
		C2H2 Zn finger	568..588	CDD:275368	9/20 (45%)
		zf-H2C2_2	580..604	CDD:404364	5/10 (50%)
		C2H2 Zn finger	596..615	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C166335946
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.930