DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment CG2199 and ZNF729

DIOPT Version :9

Sequence 1:	NP_728599.1	Gene:	CG2199 / 38159	FlyBaseID:	FBgn0035213	Length:	733	Species:	Drosophila melanogaster
Sequence 2:	NP_001229609.1	Gene:	ZNF729 / 100287226	HGNCID:	32464	Length:	1252	Species:	Homo sapiens

Alignment Length:	854	Identity:	166/854 - (19%)
Similarity:	268/854 - (31%)	Gaps:	299/854 - (35%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 QKEVRCDHCGTSQGSKSVFSGQKVFLGRKITDVLETITHRSIPSSLPIKICFVCTSTFMSSAALI 78
            :|..:|:.||      ..|.|...|...|:....|.          |.| |..|..||...:||
Human   289 EKTYKCEECG------KAFKGSSNFNAHKVIHTAEK----------PYK-CEDCGKTFNHFSAL- 335

  Fly    79 EKVRETVDRVQEQPAKKTKVAEI-EEPSTQESDKKAVKVPKKNTTLRQRSKSIAAFPPSFVNGAN 142
                           :|.|:... ::|..:|...||.   .:::|||:.
Human   336 ---------------RKHKIIHTGKKPYKREECGKAF---SQSSTLRKH---------------- 366

  Fly   143 TNTEIEIISASPKKLDKTPKKQISRLFEDNLNDSVKLTPAKEVSSTKKAFLNLFGNGGNDAIEVL 207
               ||......|.|.::..|.         ...|.|||..|.|.:.:|.:          ..|..
Human   367 ---EIIHTGEKPYKCEECGKA---------FKWSSKLTVHKVVHTGEKPY----------KCEEC 409

  Fly   208 TESEEEEDSDKGPITINTNN--FQCPEC--EFHAKF-----------PKPYK-----------EH 246
            .::..:..:.|....|:|..  ::|.||  .|::..           .||||           .|
Human   410 GKAFSQFSTLKKHKIIHTGKKPYKCEECGKAFNSSSTLMKHKIIHTGEKPYKCEECGKAFRQSSH 474

  Fly   247 LQKEHG----------------------LQRPRI-------YPCTLCIKTFGVLKTLKNH-LRDT 281
            |.:...                      |:|.:|       |.|..|.|.|....||:|| :..|
Human   475 LTRHKAIHTGEKPYKCEECGKAFNHFSDLRRHKIIHTGKKPYKCEECGKAFSQSSTLRNHQIIHT 539

  Fly   282 HSRTFESEA-----KTKAKESKEKEAKSGAKN-KIDAKAKETNAVSQRKKPKEKKSKEKKTEIKC 340
            ..:.::.|.     |..:|.:..|...:|.|. |.:...|.....|..:|.|...::||.  .||
Human   540 GEKPYKCEECGKAFKWSSKLTVHKVIHTGEKPCKCEECGKAFKHFSALRKHKVIHTREKL--YKC 602

  Fly   341 NVETKVVDEIDDQVNN-------------KKGTDSEDADQT--QATKIASFKALNESLMKKRMLE 390
                   :|.....||             ||....|:..:.  |::.:...||::
Human   603 -------EECGKAFNNSSILAKHKIIHTGKKPYKCEECGKAFRQSSHLTRHKAIH---------- 650

  Fly   391 NVIDSEYTFAINGSSASTPRADSNNFQCEICDCELMTAKQMQEHMKTVHSIDKPKVFKCHVCEKS 455
                          :...|      ::||.|.........::.| |.:|:..||  :||..|.|:
Human   651 --------------TGEKP------YKCEECGKAFSHFSALRRH-KIIHTGKKP--YKCEECGKA 692

  Fly   456 LATKQSLKTHMTLHADGAEAPN-----------SSKRKILQDEDEDVDILGTTQIENTAEKVEGP 509
            .:...:|:.|..:|.  .|.|.           |||             |...::.:||||   |
Human   693 FSHFSALRRHKIIHT--GEKPYKCEECGKAFKWSSK-------------LTVHKVIHTAEK---P 739

  Fly   510 KKSQQSPTKAAKFT---NRKILQEEDEVVEIVDAFKTDNTAEDDEGPAEEKIIRSRNNIQHQVDG 571
            .|.::.......|:   ..|::...:::.:..:..|..|:.   ....:.|:|.:........:.
Human   740 CKCEECGKSFKHFSALRKHKVIHTREKLYKCEECVKAFNSF---SALMKHKVIHTGEKPYKCEEC 801

  Fly   572 GMIAPRSPAKKTKKTSHVDLSVSTTNGNSPAKSEKRKKQDKSEDTLPSSDVDIVEEINYNVRPHK 636
            |        |..|.:|.:.:......|..|.|.|:..|..|....|....|     |:...:|:|
Human   802 G--------KAFKWSSKLTVHKVIHTGEKPCKCEECGKAFKHFSALRKHKV-----IHTGKKPYK 853

  Fly   637 KARLESIGDSTADESTL-------------SCDRCGKFVKSRQRLDSHMEKKHAAK-LQCTLCKE 687
               .|..|.:.:..|:|             .|:.|||..|...:|..|.....|.| .:|..|.:
Human   854 ---CEECGKAFSQSSSLRKHEIIHSGEKPYKCEECGKAFKWLSKLTVHKVIHTAEKPCKCEECGK 915

  Fly   688 VYQNQMDYVAHFS------------------NCGS---------------EGGLPCGVANCKKVF 719
            .::       |||                  .||.               .|..|...|.|.|.|
Human   916 AFK-------HFSALRKHKIIHTGKKPYKCEECGKAFNDSSTLMKHKIIHTGKKPYKCAECGKAF 973

  Fly   720 TEANFLSSH 728
            .:::.|:.|
Human   974 KQSSHLTRH 982

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
CG2199	NP_728599.1	C2H2 Zn finger	418..439	CDD:275370	5/20 (25%)
CG2199	NP_728599.1	C2H2 Zn finger	449..469	CDD:275370	5/19 (26%)
ZNF729	NP_001229609.1	KRAB	13..73	CDD:214630
		KRAB	13..52	CDD:279668
		C2H2 Zn finger	182..202	CDD:275368
		C2H2 Zn finger	210..230	CDD:275368
		C2H2 Zn finger	239..258	CDD:275368
		COG5048	262..666	CDD:227381	93/489 (19%)
		C2H2 Zn finger	266..286	CDD:275368
		C2H2 Zn finger	294..314	CDD:275368	7/25 (28%)
		C2H2 Zn finger	322..342	CDD:275368	8/35 (23%)
		C2H2 Zn finger	351..370	CDD:275368	8/40 (20%)
		zf-H2C2_2	363..386	CDD:290200	7/50 (14%)
		C2H2 Zn finger	378..398	CDD:275368	6/28 (21%)
		C2H2 Zn finger	406..426	CDD:275368	2/19 (11%)
		C2H2 Zn finger	434..454	CDD:275368	4/19 (21%)
		C2H2 Zn finger	462..482	CDD:275368	2/19 (11%)
		zf-H2C2_2	474..499	CDD:290200	2/24 (8%)
		C2H2 Zn finger	490..510	CDD:275368	3/19 (16%)
		zf-H2C2_2	502..527	CDD:290200	8/24 (33%)
		C2H2 Zn finger	518..538	CDD:275368	8/19 (42%)
		zf-H2C2_2	531..554	CDD:290200	5/22 (23%)
		C2H2 Zn finger	546..566	CDD:275368	4/19 (21%)
		C2H2 Zn finger	574..594	CDD:275368	4/19 (21%)
		C2H2 Zn finger	602..622	CDD:275368	4/26 (15%)
		COG5048	625..1123	CDD:227381	83/435 (19%)
		C2H2 Zn finger	630..650	CDD:275368	4/19 (21%)
		zf-H2C2_2	642..667	CDD:290200	6/54 (11%)
		C2H2 Zn finger	658..678	CDD:275368	5/20 (25%)
		zf-H2C2_2	670..695	CDD:290200	9/27 (33%)
		C2H2 Zn finger	686..706	CDD:275368	5/19 (26%)
		zf-H2C2_2	698..722	CDD:290200	5/25 (20%)
		C2H2 Zn finger	714..734	CDD:275368	4/32 (13%)
		C2H2 Zn finger	742..762	CDD:275368	2/19 (11%)
		C2H2 Zn finger	770..790	CDD:275368	3/22 (14%)
		C2H2 Zn finger	798..818	CDD:275368	4/27 (15%)
		C2H2 Zn finger	826..846	CDD:275368	5/24 (21%)
		C2H2 Zn finger	854..874	CDD:275368	4/19 (21%)
		zf-H2C2_2	866..890	CDD:290200	5/23 (22%)
		C2H2 Zn finger	882..902	CDD:275368	7/19 (37%)
		C2H2 Zn finger	910..930	CDD:275368	5/26 (19%)
		C2H2 Zn finger	938..958	CDD:275368	2/19 (11%)
		C2H2 Zn finger	966..986	CDD:275368	6/17 (35%)
		zf-H2C2_2	978..1003	CDD:290200	2/5 (40%)
		C2H2 Zn finger	994..1014	CDD:275368
		C2H2 Zn finger	1022..1042	CDD:275368
		zf-H2C2_2	1034..1058	CDD:290200
		C2H2 Zn finger	1050..1070	CDD:275368
		C2H2 Zn finger	1078..1098	CDD:275368
		C2H2 Zn finger	1106..1126	CDD:275368
		C2H2 Zn finger	1134..1154	CDD:275368
		C2H2 Zn finger	1162..1182	CDD:275368
		C2H2 Zn finger	1190..1210	CDD:275368
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C165142262
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoDB	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	0	0.000	Not matched by this tool.
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
SwiftOrtho	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
User_Submission	0	0.000	Not matched by this tool.
	1	0.930