Protein Alignment Myo61F and MYH13

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_003793.2
• Gene: MYH13 / 8735
• HGNCID: 7571
• Length: 1938
• Species: Homo sapiens
• Alignment Length: 1086
• Identity: 325/1086 - (29%)
• Similarity: 520/1086 - (47%)
• Gaps: 188/1086 - (17%)

  Fly    39 VQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKHFYEM 103
            ::|..:: .:..|.|.:.|||:|:...:||||.|...::|||||.||:|..:.|.|||.|...|.
Human    88 IEDMAMM-THLHEPAVLYNLKERYAAWMIYTYSGLFCVTVNPYKWLPVYKPEVVAAYRGKKRQEA 151

  Fly   104 PPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIA--ACSGN----------QT 156
            |||||:::|||::.::.:...|.:||:||||:|||..:|:|:|:.|  |.:|:          |.
Human   152 PPHIFSISDNAYQFMLTDRDNQSILITGESGAGKTVNTKRVIQYFATIAVTGDKKKETQPGKMQG 216

  Fly   157 TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQ 221
            |:|   |:::::||:|||||||||.||||||||||::.|.|...|.....:|..||||||||..|
Human   217 TLE---DQIIQANPLLEAFGNAKTVRNDNSSRFGKFIRIHFGATGKLASADIETYLLEKSRVTFQ 278

  Fly   222 MGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVID 286
            :..||::|||||:::.....|:..|.:......:.:::.| ..||..|:|::.......|:.::.
Human   279 LSSERSYHIFYQIMSNKKPELIDLLLISTNPFDFPFVSQG-EVTVASIDDSEELLATDNAIDILG 342

  Fly   287 FTKEEQREIFGIVASILHLGNVGFTEV--EGNAKVNSRDLVVTAARLLGVNASELEAALTHRTID 349
            |:.||:..|:.:..:::|.||:.|.:.  |..|:.:..::...|..|:|:|::|:...|....:.
Human   343 FSSEEKVGIYKLTGAVMHYGNMKFKQKQREEQAEPDGTEVADKAGYLMGLNSAEMLKGLCCPRVK 407

  Fly   350 ARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNVMGILDIYGFEI 414
            ...:.||...|.:....:..|||||||:::|.|:|.|:|   |..:|:..|...:|:|||.||||
Human   408 VGNEYVTKGQNVQQVTNSVGALAKAVYEKMFLWMVTRIN---QQLDTKQPRQYFIGVLDIAGFEI 469

  Fly   415 FQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIIS 479
            |..||.||.||||.||||||.|.......||:||::|||||..:::..:...|..:.||..||.|
Human   470 FDFNSLEQLCINFTNEKLQQFFNHHMFVLEQEEYKKEGIEWEFIDFGMDLAACIELIEKPMGIFS 534

  Fly   480 ILDEECLRPGEPTDKTFLEKL-TQKLAQHHHY----VCHEKAPAHIKKIMLRDEFRLVHYAGEVT 539
            ||:|||:.| :.||.:|..|| .|.|.:.:::    ....||.||         |.||||||.|.
Human   535 ILEEECMFP-KATDTSFKNKLYDQHLGKSNNFQKPKPAKGKAEAH---------FSLVHYAGTVD 589

  Fly   540 YSVNGFLDKNNDLLFRDLKETL-----------------------------SKAGNGIVRNCFPE 575
            |::.|:||||.|    .|.||:                             ||.|.....:.|
Human   590 YNIAGWLDKNKD----PLNETVVGLYQKSSLKLLSFLFSNYAGAETGDSGGSKKGGKKKGSSF-- 648

  Fly   576 KELRSLKRPETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLME 640
                     :|....||.:||.||..|....|.::||:.||:.:|..|.:..||:||::..|::|
Human   649 ---------QTVSAVFRENLNKLMTNLRSTHPHFVRCLIPNETKTPGVMDHYLVMHQLRCNGVLE 704

  Fly   641 NLRVRRAGFAYRRTYELFLERYKSLSKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLF 705
            .:|:.|.||..|..|..|.:||:.|:.|..|..:......|. ::|:..:..|.|::|.|.||:|
Human   705 GIRICRKGFPSRILYADFKQRYRILNASAIPEGQFIDSKNAS-EKLLNSIDVDREQFRFGNTKVF 768

  Fly   706 IRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQR---RKYLKLRAQVIIMQSYCRR-------- 759
            .: ...|...|:...||...:....||..:|.:.|   :|.::.|..:..:|...|.
Human   769 FK-AGLLGLLEEMRDEKLVTLMTSTQAVCRGYLMRVEFKKMMERRDSIFCIQYNIRSFMNVKHWP 832

  Fly   760 --------KLAQQAAKKRREAADKIRAF--IKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELP 814
                    |...::|:..:|.|.....|  .|..:.|::|.....||     |.:.||:...:|.
Human   833 WMNLFFKIKPLLKSAEAEKEMATMKEDFERTKEELARSEARRKELEE-----KMVSLLQEKNDLQ 892

  Fly   815 TKVLD--KSWPHAPGHCEEASGILHRLHRLHLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNY 877
            .:|..  ::...|...||   |::.....|. |::..|....:::.:...:::|      ||.|.
Human   893 LQVQSETENLMDAEERCE---GLIKSKILLE-AKVKELTERLEEEEEMNSELVA------KKRNL 947

  Fly   878 ASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTKFDRHGYKSRDRFILLS------- 935
            ....|:           ::|..|.:..|.           ||.::..:.:.::...||
Human   948 EDKCSS-----------LKRDIDDLELTL-----------TKVEKEKHATENKVKNLSEEMTALE 990

  Fly   936 -NKAIYVLDGKTYKQKHRLPLD-------------KIDFTLTNHNDDL-------MVIRIPLDLK 979
             |.:....:.|:.::.|:..||             ||:..|....|||       ..:|..|:..
Human   991 ENISKLTKEKKSLQEAHQQTLDDLQVEEDKVNGLIKINAKLEQQTDDLEGSLEQEKKLRADLERA 1055

  Fly   980 KDK--GDLILIIPRIIEFSTYIIDTVGTASIVSIVDRNSLEHNVVK 1023
            |.|  |||.:....|::...               |:..:|..:.|
Human  1056 KRKLEGDLKMSQESIMDLEN---------------DKQQIEEKLKK 1086

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	255/702 (36%)
		Myosin_TH1	863..1049	CDD:461801	34/191 (18%)
MYH13	NP_003793.2	Myosin_N	33..77	CDD:460670
		MYSc_Myh13	100..770	CDD:276887	255/702 (36%)
		Actin-binding. /evidence=ECO:0000250	659..681		9/21 (43%)
		Actin-binding. /evidence=ECO:0000250	761..775		5/14 (36%)
		Myosin_tail_1	850..1927	CDD:460256	54/289 (19%)
		Disordered. /evidence=ECO:0000256|SAM:MobiDB-lite	1917..1938