Protein Alignment Myo61F and MYO1

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_011888.1
• Gene: MYO1 / 856418
• SGDID: S000001065
• Length: 1928
• Species: Saccharomyces cerevisiae
• Alignment Length: 1057
• Identity: 326/1057 - (30%)
• Similarity: 527/1057 - (49%)
• Gaps: 156/1057 - (14%)

  Fly    42 FVLLEN-----YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKH-- 99
            |..:||     :.:|.:.:.||:||:..||||||.|..|:::|||..|.:|::||:..|.|||
Yeast    74 FDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNR 138

  Fly   100 ----------FYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAA-CSG 153
                      ..::||||||:.:.|:.:|:.|.:.|.:|::||||:||||.:||:||::|: .||
Yeast   139 LSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSG 203

  Fly   154 N---------QTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNIL 209
            :         .:.||..:.|:|:|||:||:||||:|.||:|||||||::.|:|:..|...|.:|.
Yeast   204 SPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIE 268

  Fly   210 NYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLE-RALDTYSYLTDGLNGTVTRINDAD 273
            .|||||||:|.|...|||:|||||||:|.|::.|:.|||: |.:..|..|::.....:..|||.:
Yeast   269 WYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVE 333

  Fly   274 SFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASE 338
            :||::..||.:|.|:|::.|.||.:||.||.:||:.|............|:....:. |||:..:
Yeast   334 NFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKNDVSAICSN-LGVDEKD 397

  Fly   339 LEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNV 403
            .:.|:......|..:.|:...|.:.|.:..:||::.:|:|||.::|..:|.:|   :..::..|.
Yeast   398 FQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNL---DHGSATLNY 459

  Fly   404 MGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVIC 467
            :|:|||.|||||:.|||||.|||:.||||||.|.......||.||.:|.|:|..::| .|.::..
Yeast   460 IGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTI 524

  Fly   468 NLIEEK--HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFR 530
            :|||.|  ..|::.:||||.:.| :.||::|..||.....|:         .:..|:..|::.|.
Yeast   525 DLIESKGPPTGVLPLLDEEAVLP-KSTDESFYSKLISTWDQN---------SSKFKRSRLKNGFI 579

  Fly   531 LVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCF-PEKELRS------------LK 582
            |.||||:|.|:|.|:|.||.|.|..:|...||.:.|.|:...| ||.|..|            :|
Yeast   580 LKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVK 644

  Fly   583 RP------ETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMEN 641
            :.      :|..::.|.....|::.|....|.::|||.||:::....||..|:|.|::..|::|.
Yeast   645 KSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEG 709

  Fly   642 LRVRRAGFAYRRTYELFLERYKSL----SKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGET 702
            :|:.|.|:..|..::.|.:||:.|    |.:|..:.|.....|...:.|:..|..|.:.|::|.|
Yeast   710 IRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNT 774

  Fly   703 KLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYL----KLRAQVIIMQSY-CRRKLA 762
            |||.: ...|.|.|.....|.:.|...:.|..:|...|::..    ||:...:|..:: ...:|.
Yeast   775 KLFFK-AGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLV 838

  Fly   763 QQ---------------------AAKKRREAADKIRAFI------KGFI------TRNDAPNG-- 792
            ::                     ..||..|..:|::..:      |.|:      |.|:..|.
Yeast   839 KEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQD 903

  Fly   793 -FNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEAS----GILHRLHRLHLARIYRLKL 852
             .|:|.....|...||...| ..::.|.|.:.......:|.|    .:...|...|      .|:
Yeast   904 LLNQEKENLRKNESLLNRVK-TSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAH------QKI 961

  Fly   853 TPQQKRQFELKVLAEKVFKGKKNNYASSVS-------------TWFQEDRIPKEH-IQRVNDFVA 903
            ...|:...|.:...||: ..|.|.....:|             :..:|.::..|: |:|:.|.:.
Yeast   962 QGLQETIREREATLEKL-HSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVIN 1025

  Fly   904 STFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDD 968
            |.  .|::|  ||..|             |.|::....:...|.::...:.:.::. :|...|.|
Yeast  1026 SK--EEEIK--SFNDK-------------LSSSEEDLDIKLVTLEKNCNIAMSRLQ-SLVTENSD 1072

  Fly   969 LMVIRIPLDLKKDKGDL 985
            |....  .:.||:|..|
Yeast  1073 LRSKN--ENFKKEKAAL 1087

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	259/703 (37%)
		Myosin_TH1	863..1049	CDD:461801	27/137 (20%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	326/1057 (31%)
		Smc	1607..>1901	CDD:440809