DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYO1

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_011888.1	Gene:	MYO1 / 856418	SGDID:	S000001065	Length:	1928	Species:	Saccharomyces cerevisiae

Alignment Length:	1057	Identity:	326/1057 - (30%)
Similarity:	527/1057 - (49%)	Gaps:	156/1057 - (14%)

- Green bases have known domain annotations that are detailed below.

  Fly    42 FVLLEN-----YQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLPIYTDDHVKAYRNKH-- 99
            |..:||     :.:|.:.:.||:||:..||||||.|..|:::|||..|.:|::||:..|.|||
Yeast    74 FDKVENMSELTHLNEPSVLYNLEKRYDCDLIYTYSGLFLVAINPYHNLNLYSEDHINLYHNKHNR 138

  Fly   100 ----------FYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAA-CSG 153
                      ..::||||||:.:.|:.:|:.|.:.|.:|::||||:||||.:||:||::|: .||
Yeast   139 LSKSRLDENSHEKLPPHIFAIAEEAYENLLSEGKDQSILVTGESGAGKTENTKKILQYLASITSG 203

  Fly   154 N---------QTTVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNIL 209
            :         .:.||..:.|:|:|||:||:||||:|.||:|||||||::.|:|:..|...|.:|.
Yeast   204 SPSNIAPVSGSSIVESFEMKILQSNPILESFGNAQTVRNNNSSRFGKFIKIEFNEHGMINGAHIE 268

  Fly   210 NYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLE-RALDTYSYLTDGLNGTVTRINDAD 273
            .|||||||:|.|...|||:|||||||:|.|::.|:.|||: |.:..|..|::.....:..|||.:
Yeast   269 WYLLEKSRIVHQNSKERNYHIFYQLLSGLDDSELKNLRLKSRNVKDYKILSNSNQDIIPGINDVE 333

  Fly   274 SFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEGNAKVNSRDLVVTAARLLGVNASE 338
            :||::..||.:|.|:|::.|.||.:||.||.:||:.|............|:....:. |||:..:
Yeast   334 NFKELLSALNIIGFSKDQIRWIFQVVAIILLIGNIEFVSDRAEQASFKNDVSAICSN-LGVDEKD 397

  Fly   339 LEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRNNV 403
            .:.|:......|..:.|:...|.:.|.:..:||::.:|:|||.::|..:|.:|   :..::..|.
Yeast   398 FQTAILRPRSKAGKEWVSQSKNSQQAKFILNALSRNLYERLFGYIVDMINKNL---DHGSATLNY 459

  Fly   404 MGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY-FDNKVIC 467
            :|:|||.|||||:.|||||.|||:.||||||.|.......||.||.:|.|:|..::| .|.::..
Yeast   460 IGLLDIAGFEIFENNSFEQLCINYTNEKLQQFFNNHMFVLEQSEYLKENIQWDYIDYGKDLQLTI 524

  Fly   468 NLIEEK--HKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRDEFR 530
            :|||.|  ..|::.:||||.:.| :.||::|..||.....|:         .:..|:..|::.|.
Yeast   525 DLIESKGPPTGVLPLLDEEAVLP-KSTDESFYSKLISTWDQN---------SSKFKRSRLKNGFI 579

  Fly   531 LVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCF-PEKELRS------------LK 582
            |.||||:|.|:|.|:|.||.|.|..:|...||.:.|.|:...| ||.|..|            :|
Yeast   580 LKHYAGDVEYTVEGWLSKNKDPLNDNLLSLLSSSQNDIISKLFQPEGEKSSSAGVEANISNQEVK 644

  Fly   583 RP------ETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMEN 641
            :.      :|..::.|.....|::.|....|.::|||.||:::....||..|:|.|::..|::|.
Yeast   645 KSARTSTFKTTSSRHREQQITLLNQLASTHPHFVRCIIPNNVKKVKTFNRRLILDQLRCNGVLEG 709

  Fly   642 LRVRRAGFAYRRTYELFLERYKSL----SKSTWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGET 702
            :|:.|.|:..|..::.|.:||:.|    |.:|..:.|.....|...:.|:..|..|.:.|::|.|
Yeast   710 IRLAREGYPNRIAFQEFFQRYRILYPENSTTTTFSSKLKASTKQNCEFLLTSLQLDTKVYKIGNT 774

  Fly   703 KLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYL----KLRAQVIIMQSY-CRRKLA 762
            |||.: ...|.|.|.....|.:.|...:.|..:|...|::..    ||:...:|..:: ...:|.
Yeast   775 KLFFK-AGVLADLEKQKDVKLNNIMIKLTATIRGYTVRKEITYHLQKLKKTRVIGNTFRLYNRLV 838

  Fly   763 QQ---------------------AAKKRREAADKIRAFI------KGFI------TRNDAPNG-- 792
            ::                     ..||..|..:|::..:      |.|:      |.|:..|.
Yeast   839 KEDPWFNLFIRIKPLLTSSNDMTRTKKFNEQINKLKNDLQEMESKKKFLEEKNQKTVNELENTQD 903

  Fly   793 -FNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEAS----GILHRLHRLHLARIYRLKL 852
             .|:|.....|...||...| ..::.|.|.:.......:|.|    .:...|...|      .|:
Yeast   904 LLNQEKENLRKNESLLNRVK-TSSETLQKQFDDLVSEKDEISREKLEVAQNLEEAH------QKI 961

  Fly   853 TPQQKRQFELKVLAEKVFKGKKNNYASSVS-------------TWFQEDRIPKEH-IQRVNDFVA 903
            ...|:...|.:...||: ..|.|.....:|             :..:|.::..|: |:|:.|.:.
Yeast   962 QGLQETIREREATLEKL-HSKNNELIKQISDLNCDISKEQSSQSLIKESKLKLENEIKRLKDVIN 1025

  Fly   904 STFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKTYKQKHRLPLDKIDFTLTNHNDD 968
            |.  .|::|  ||..|             |.|::....:...|.::...:.:.::. :|...|.|
Yeast  1026 SK--EEEIK--SFNDK-------------LSSSEEDLDIKLVTLEKNCNIAMSRLQ-SLVTENSD 1072

  Fly   969 LMVIRIPLDLKKDKGDL 985
            |....  .:.||:|..|
Yeast  1073 LRSKN--ENFKKEKAAL 1087

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	266/731 (36%)
		MYSc_Myo1	52..707	CDD:276829	259/703 (37%)
		Myosin_TH1	863..1035	CDD:283635	27/137 (20%)
MYO1	NP_011888.1	COG5022	2..1691	CDD:227355	326/1057 (31%)
MYO1	NP_011888.1	Smc	1534..>1890	CDD:224117
Blue background indicates that the domain is not in the aligned region.

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910