Protein Alignment Myo61F and MYO5

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_013827.1
• Gene: MYO5 / 855136
• SGDID: S000004715
• Length: 1219
• Species: Saccharomyces cerevisiae
• Alignment Length: 1005
• Identity: 369/1005 - (36%)
• Similarity: 533/1005 - (53%)
• Gaps: 156/1005 - (15%)

  Fly    21 FNSQLKMETGLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLISVNPYKQLP 85
            |:|..|.|        .||.|..||... |:||...||||||....||||||.|||||||::.|.
Yeast    28 FDSSKKKE--------VGVSDLTLLSKI-SDEAINENLKKRFLNATIYTYIGHVLISVNPFRDLG 83

  Fly    86 IYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASKKVLQFIAA 150
            ||||..:..|:.|:..|:|||:||:.::.:.::...|..|||:||||||:|||||:|:::|:|||
Yeast    84 IYTDAVMNEYKGKNRLEVPPHVFAIAESMYYNMKSYNENQCVIISGESGAGKTEAAKRIMQYIAA 148

  Fly   151 CSGNQT-TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLE 214
            .|...| ::..:||.:|.:||:||:||.|||.||:||||.|||::|:|:.:..|..|||.|||||
Yeast   149 ASSTHTESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNNQFEPCAGNITNYLLE 213

  Fly   215 KSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRINDADSFKQVQ 279
            |.|||:|:..|||||||||...||.:|..|...:::. :.|.|.......:...|:|...:::..
Yeast   214 KQRVVSQIKNERNFHIFYQFTKGASDAYRQTFGVQKP-EQYVYTAAAGCISAETIDDLQDYQETL 277

  Fly   280 QALTVIDFTKEEQREIFGIVASILHLGNVGFTE-VEGNAKVNSRDLVVT--AARLLGVNASELEA 341
            :|:.||...:|||.:||.::|:||.:|||.|.| .||||:|  ||..||  .|.||.:::..|..
Yeast   278 KAMRVIGLGQEEQDQIFRMLAAILWIGNVSFIENEEGNAQV--RDTSVTDFVAYLLQIDSQLLIK 340

  Fly   342 ALTHRTIDA-----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKETRASRN 401
            :|..|.::.     ||.|...|||...|...|||||||:|:.||.|:|.|:|.||||   .....
Yeast   341 SLVERIMETNHGMKRGSVYHVPLNIVQADAVRDALAKAIYNNLFDWIVSRVNKSLQA---FPGAE 402

  Fly   402 NVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEYFDNKVI 466
            ..:|||||||||||:.|||||.|||:.||||||:||:|||||||:.|.||.|:|.|::||||||:
Yeast   403 KSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKSEQETYEREKIQWTPIKYFDNKVV 467

  Fly   467 CNLIEEKH-KGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIKKIMLRD 527
            |:|||.:. .||.:.:::...   ......|:.|.::|.......|..:...|
Yeast   468 CDLIEARRPPGIFAAMNDSVATAHADSNAADQAFAQRLNLFTTNPHFDLRSNK------------ 520

  Fly   528 EFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEK-ELRSLKRPETAITQF 591
             |.:.||||:|||.::|..|||.|.|.:||.|.:....|..:...||:. :..|.:||.||..:.
Yeast   521 -FVIKHYAGDVTYDIDGITDKNKDQLQKDLVELIGTTTNTFLATIFPDTVDRESKRRPPTAGDKI 584

  Fly   592 RASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYE 656
            ..|.|:|::.|...:|||||.||||:.::.|.::|..||||:|||||.||:|:||||||||:.:|
Yeast   585 IKSANDLVETLSKAQPSYIRTIKPNETKSPNDYDDRQVLHQIKYLGLQENVRIRRAGFAYRQVFE 649

  Fly   657 LFLERYKSLSK--STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAY 719
            .|:||:..||.  |...:|...|.....|:.:::|....:::|::|.|.:||:.|.|||..|...
Yeast   650 KFVERFYLLSPHCSYAGDYTWQGDTLDAVKYILQDSSIPQQEYQLGVTSVFIKTPETLFALEHMR 714

  Fly   720 QEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFI 784
            ....|.:||.||..|:..:||                            |.:||.||:..|:
Yeast   715 DRYWHNMAARIQRAWRRFLQR----------------------------RIDAATKIQRTIR--- 748

  Fly   785 TRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRLHLARIYR 849
                                                         |...|     ::....|.|.
Yeast   749 ---------------------------------------------ERKEG-----NKYEKLRDYG 763

  Fly   850 LKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQR---VNDFVASTFGSEQL 911
            .|:...:|.:..:.:|..:.|.|   :|.|.     .|.:....:|:|   :.:.|..:...|.|
Yeast   764 TKVLGGRKERRSMSLLGYRAFMG---DYLSC-----NESKSKGAYIKRQVSIKEKVIFSIHGEAL 820

  Fly   912 KYQSFCTKFDRHGYKSRDRFILLSNKAIYVL------DGKTYKQKHRLPLDKID-FTLTNHNDDL 969
            .     |||.|...:.:..| ||:...:|::      :..||.|.:::.:..|. .:|||..||.
Yeast   821 H-----TKFGRSAQRLKKTF-LLTPTTLYIVGQTLVQNAMTYTQDYKIDVRNIQAVSLTNLQDDW 879

  Fly   970 MVIRI-------PLDLKKDKGDLILIIPRI 992
            :.|::       ||.....|.:||..:.|:
Yeast   880 VAIKLASSGQPDPLINTYFKTELITHLKRL 909

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	298/670 (44%)
		Myosin_TH1	863..1049	CDD:461801	35/147 (24%)
MYO5	NP_013827.1	COG5022	1..1186	CDD:227355	369/1005 (37%)