Protein Alignment Myo61F and MYO2

DIOPT Version :10

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_014971.1
• Gene: MYO2 / 854504
• SGDID: S000005853
• Length: 1574
• Species: Saccharomyces cerevisiae
• Alignment Length: 1049
• Identity: 333/1049 - (31%)
• Similarity: 514/1049 - (48%)
• Gaps: 172/1049 - (16%)

  Fly    13 MDTKDYIDFNSQLKMETGLHERDRAGVQDFVLLEN--------------YQSEEAFIGNLKKRFQ 63
            :|||   |.|         :::|    |...||.|              |.:|.|.:..:|:|:.
Yeast    47 VDTK---DLN---------NDKD----QSLPLLRNPPILEATEDLTSLSYLNEPAVLHAIKQRYS 95

  Fly    64 EDLIYTYIGQVLISVNPYKQL-PIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCV 127
            :..||||.|.|||:.||:.:: .:||.|.::||..|...|:.||:||:.:.|:|.:..:.:.|.:
Yeast    96 QLNIYTYSGIVLIATNPFDRVDQLYTQDMIQAYAGKRRGELEPHLFAIAEEAYRLMKNDKQNQTI 160

  Fly   128 LISGESGSGKTEASKKVLQFIAAC-SGNQTTVE------GVKDKLLKSNPVLEAFGNAKTNRNDN 185
            ::|||||:|||.::|.::::.|:. ..|..||:      ..:.|:|.:||::||||||||.||||
Yeast   161 VVSGESGAGKTVSAKYIMRYFASVEEENSATVQHQVEMSETEQKILATNPIMEAFGNAKTTRNDN 225

  Fly   186 SSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLER 250
            |||||||::|.||...:.||..|..||||:||:|.|...|||:||||||:||......:||.|..
Yeast   226 SSRFGKYLEILFDKDTSIIGARIRTYLLERSRLVYQPPIERNYHIFYQLMAGLPAQTKEELHLTD 290

  Fly   251 ALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTEVEG 315
            |.| |.|:..|.:..:..|:||..:|....|||::..|||.|.:||.|:|::||:||:...:...
Yeast   291 ASD-YFYMNQGGDTKINGIDDAKEYKITVDALTLVGITKETQHQIFKILAALLHIGNIEIKKTRN 354

  Fly   316 NAKVNSRD-LVVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAVYDRL 379
            :|.:::.: .:..|..|||::|......:|.:.|..|.:.:.|.||...|:.|:|::||.:|..|
Yeast   355 DASLSADEPNLKLACELLGIDAYNFAKWVTKKQIITRSEKIVSNLNYSQALVAKDSVAKFIYSAL 419

  Fly   380 FSWLVQRLNISLQAKETRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSE 444
            |.|||:.:|..|.........::.:|:|||||||.|:||||||||||:.||||||.|.:...|.|
Yeast   420 FDWLVENINTVLCNPAVNDQISSFIGVLDIYGFEHFEKNSFEQFCINYANEKLQQEFNQHVFKLE 484

  Fly   445 QDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQKLAQHHH 509
            |:||.:|.|||..:|:.||:...:|||.| .||:|:||||...|. .:|:::.:||.|.|
Yeast   485 QEEYVKEEIEWSFIEFNDNQPCIDLIENK-LGILSLLDEESRLPA-GSDESWTQKLYQTL----- 542

  Fly   510 YVCHEKAPAHIKKIMLR-----DEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIV 569
                :|:|.:  |:..:     .:|.:.|||.:|.|.|.||::||.|.:.....|.|..:.|..:
Yeast   543 ----DKSPTN--KVFSKPRFGQTKFIVSHYALDVAYDVEGFIEKNRDTVSDGHLEVLKASTNETL 601

  Fly   570 RNCFPEKE------------------------LRSLKRPETAITQFRASLNNLMDILMCKEPSYI 610
            .|.....|                        :|::.|..|..:.|:.||..||:.:......||
Yeast   602 INILEGLEKAAKKLEEAKKLELEQAGSKKPGPIRTVNRKPTLGSMFKQSLIELMNTINSTNVHYI 666

  Fly   611 RCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSL-SKSTWP-NY 673
            ||||||..:.|..|::.:||.|::..|::|.:|:..|||..|.|:|.|:.||..| ....|. .:
Yeast   667 RCIKPNADKEAWQFDNLMVLSQLRACGVLETIRISCAGFPSRWTFEEFVLRYYILIPHEQWDLIF 731

  Fly   674 KGPGGPKAGVQQLVKDL----GWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHW 734
            |.....:..:..:||.:    ..|:.||::|.||:|.: ...|...|.....|.|....:||...
Yeast   732 KKKETTEEDIISVVKMILDATVKDKSKYQIGNTKIFFK-AGMLAYLEKLRSNKMHNSIVMIQKKI 795

  Fly   735 KGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIRAFIKGFITRNDAPNGFNEEFIA 799
            :....|::||::...:..:|:.                       |||||.|...    |:|...
Yeast   796 RAKYYRKQYLQISQAIKYLQNN-----------------------IKGFIIRQRV----NDEMKV 833

  Fly   800 NAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEAS--GILHRLHRLHLARIYRLKLTPQQKRQFEL 862
            |...  ||:.|..              ||...|:  .:|..:..|            |:|.:.||
Yeast   834 NCAT--LLQAAYR--------------GHSIRANVFSVLRTITNL------------QKKIRKEL 870

  Fly   863 KVLAEKVFKGKKNNY------ASSVSTWFQEDRI--PKEHIQRVNDFVASTFGSEQLKYQSFCTK 919
            |   ::..| :::.|      .|.|.|:....|.  .|:....|...:.......:||......|
Yeast   871 K---QRQLK-QEHEYNAAVTIQSKVRTFEPRSRFLRTKKDTVVVQSLIRRRAAQRKLKQLKADAK 931

  Fly   920 FDRH----GYKSRDRFI-LLSNKAIYVLDGKTYKQK-HRLPLD-----KIDFTLTNHNDDLMVIR 973
            ...|    .||..::.| |..|.|..|.:.|...:: ..|.:.     |:..||.|...:.:
Yeast   932 SVNHLKEVSYKLENKVIELTQNLASKVKENKEMTERIKELQVQVEESAKLQETLENMKKEHL--- 993

  Fly   974 IPLDLKKDK 982
            |.:|.:|.|
Yeast   994 IDIDNQKSK 1002

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc_Myo1	52..707	CDD:276829	260/698 (37%)
		Myosin_TH1	863..1049	CDD:461801	30/139 (22%)
MYO2	NP_014971.1	COG5022	2..1567	CDD:227355	333/1049 (32%)