DRSC - DRSC Integrative Ortholog Prediction Tool

back to: DIOPT - Ortholog Prediction Tool / DIOPT for Diseases and Traits

Protein Alignment Myo61F and MYO3

DIOPT Version :9

Sequence 1:	NP_476934.2	Gene:	Myo61F / 38153	FlyBaseID:	FBgn0010246	Length:	1052	Species:	Drosophila melanogaster
Sequence 2:	NP_012793.2	Gene:	MYO3 / 853729	SGDID:	S000001612	Length:	1272	Species:	Saccharomyces cerevisiae

Alignment Length:	1027	Identity:	373/1027 - (36%)
Similarity:	549/1027 - (53%)	Gaps:	160/1027 - (15%)

- Green bases have known domain annotations that are detailed below.

  Fly    14 DTKDYIDFNSQLKMET-GLHERDRAGVQDFVLLENYQSEEAFIGNLKKRFQEDLIYTYIGQVLIS 77
            |.|:....::::|..| ..:::...|:.|..||... |:|:...||||||:..:||||||.||||
Yeast    12 DVKEPKKRSAKIKKATFDANKKKEVGISDLTLLSKI-SDESINENLKKRFKNGIIYTYIGHVLIS 75

  Fly    78 VNPYKQLPIYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEENRGQCVLISGESGSGKTEASK 142
            |||::.|.|||:..:::|:.|:..|:|||:||:.::.:.:|...|..|||:||||||:|||||:|
Yeast    76 VNPFRDLGIYTNAVLESYKGKNRLEVPPHVFAIAESMYYNLKSYNENQCVIISGESGAGKTEAAK 140

  Fly   143 KVLQFIAACSGNQT-TVEGVKDKLLKSNPVLEAFGNAKTNRNDNSSRFGKYMDIQFDFKGAPIGG 206
            :::|:|||.|.:.: ::..:||.:|.:||:||:||.|||.||:||||.|||::|:|:.:..|..|
Yeast   141 RIMQYIAAASNSHSESIGKIKDMVLATNPLLESFGCAKTLRNNNSSRHGKYLEIKFNSQFEPCAG 205

  Fly   207 NILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQELRLERALDTYSYLTDGLNGTVTRIND 271
            ||.||||||.|||.|:..|||||||||...||.:...|...::.. :.|.|.......|...|:|
Yeast   206 NITNYLLEKQRVVGQIKNERNFHIFYQFTKGASDTYKQMFGVQMP-EQYIYTAAAGCTTADTIDD 269

  Fly   272 ADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFTE-VEGNAKVNSRDLVVTAARLLGVN 335
            ...::...:|:..|...:|||.:||.::|:||.:||:.|.| .||||:|....:....|.||.|:
Yeast   270 VKDYEGTLEAMRTIGLVQEEQDQIFRMLAAILWIGNISFIENEEGNAQVGDTSVTDFVAYLLQVD 334

  Fly   336 ASELEAALTHRTIDA-----RGDVVTSPLNQELAIYARDALAKAVYDRLFSWLVQRLNISLQAKE 395
            ||.|...|..|.:..     ||.|...|||...|...|||||||:|:.||.|:|.|:|:||||
Yeast   335 ASLLVKCLVERIMQTSHGMKRGSVYHVPLNPVQATAVRDALAKAIYNNLFDWIVDRVNVSLQA-- 397

  Fly   396 TRASRNNVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIELTLKSEQDEYRREGIEWIPVEY 460
             ....:..:|||||||||||:.|||||.|||:.||||||:||:||||:||:.|.||.|:|.|::|
Yeast   398 -FPGADKSIGILDIYGFEIFEHNSFEQICINYVNEKLQQIFIQLTLKAEQETYEREKIKWTPIKY 461

  Fly   461 FDNKVICNLIEEKH-KGIISILDEECL---RPGEPTDKTFLEKLTQKLAQHHHYVCHEKAPAHIK 521
            |||||:|:|||.|: .||::.:::...   ......|:.|.::|  .|...:.|
Yeast   462 FDNKVVCDLIEAKNPPGILAAMNDSIATAHADSNAADQAFAQRL--NLFNSNPY----------- 513

  Fly   522 KIMLR-DEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAGNGIVRNCFPEK-ELRSLKRP 584
             ..|| ::|.:.||||:|||.:||..|||.|.|.:||.|.:....|..:...||:. :..|.:||
Yeast   514 -FELRANKFVIKHYAGDVTYDINGITDKNKDQLQKDLIELIGTTTNTFLSTIFPDDVDKDSKRRP 577

  Fly   585 ETAITQFRASLNNLMDILMCKEPSYIRCIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGF 649
            .||..:...|.|.|::.|...||||||.||||..::.|.::|..||||||||||.||:|:|||||
Yeast   578 PTAGDKIIKSANELVETLSKAEPSYIRTIKPNQTKSPNDYDDHQVLHQVKYLGLQENVRIRRAGF 642

  Fly   650 AYRRTYELFLERYKSLSK--STWPNYKGPGGPKAGVQQLVKDLGWDEEKYRVGETKLFIRWPRTL 712
            |||:|:|.|:||:..||.  |...:|...|.....|:.:::|....|:::::|.|.:||:.|.:|
Yeast   643 AYRQTFEKFVERFYLLSPDCSYAGDYTWDGDTLEAVKLILRDAMIPEKEFQLGVTSVFIKTPESL 707

  Fly   713 FDTEDAYQEKKHEIAAIIQAHWKGLMQRRKYLKLRAQVIIMQSYCRRKLAQQAAKKRREAADKIR 777
            |..||...:..:.:||.||..|:..:||                            |.:||.||:
Yeast   708 FALEDMRDKYWYNMAARIQRAWRRFLQR----------------------------RIDAAIKIQ 744

  Fly   778 AFIKGFITRNDAPNGFNEEFIANAKRMWLLRLAKELPTKVLDKSWPHAPGHCEEASGILHRLHRL 842
            ..|:                                                |:..|     ::.
Yeast   745 RTIR------------------------------------------------EKKGG-----NKY 756

  Fly   843 HLARIYRLKLTPQQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQR---VNDFVAS 904
            ...|.|..||...:|.:..:.:|..:.|.|   :|.|.     .|.:....:|:|   :.|.|..
Yeast   757 VKLRDYGTKLLAGKKERRSMSLLGYRAFMG---DYLSC-----NESKTKGSYIRRQVGIKDKVVF 813

  Fly   905 TFGSEQLKYQSFCTKFDRHGYKSRDRFILLSNKAIYVLDGKT-------YKQKHRLPLDKI-DFT 961
            :...|.|.     :||.|...:.:..|| |:.|..|:: |:|       |.|.:::.:.|| ..:
Yeast   814 SIKGECLH-----SKFGRSAQRLKKVFI-LTKKTFYII-GQTREQNAMKYTQDYKIDVGKIKQVS 871

  Fly   962 LTNHNDDLM------------VIRIPLD------LKKDKGDLILIIPRIIEF 995
            |||..||.|            :|..|..      |||....:::.:...||:
Yeast   872 LTNLQDDWMGVILVNSTQSDPLINTPFKTELMTRLKKLNEKIMIKVGPTIEY 923

Known Domains:

Indicated by green bases in alignment.

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	310/702 (44%)
		MYSc_Myo1	52..707	CDD:276829	299/669 (45%)
		Myosin_TH1	863..1035	CDD:283635	39/162 (24%)
MYO3	NP_012793.2	COG5022	1..1258	CDD:227355	373/1027 (36%)

Information from Original Tools:

Tool	Simple Score	Weighted Score	Original Tool Information
Tool	Simple Score	Weighted Score	BLAST Result	Score	Score Type	Cluster ID
Compara	1	0.930	-	-		C157344900
Domainoid	1	1.000	529	1.000	Domainoid score	I38
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	1	1.050	562	1.000	Inparanoid score	I159
Isobase	1	0.950	-	0	Normalized mean entropy	S951
OMA	0	0.000	Not matched by this tool.
OrthoFinder	1	1.000	-	-		FOG0000187
OrthoInspector	1	1.000	-	-		mtm9169
orthoMCL	1	0.900	-	-		OOG6_100187
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	1	0.960	-	-
	9	8.700