Protein Alignment Myo61F and MYO4

DIOPT Version :9

• Sequence 1: NP_476934.2
• Gene: Myo61F / 38153
• FlyBaseID: FBgn0010246
• Length: 1052
• Species: Drosophila melanogaster
• Sequence 2: NP_009373.1
• Gene: MYO4 / 851204
• SGDID: S000000027
• Length: 1471
• Species: Saccharomyces cerevisiae
• Alignment Length: 1180
• Identity: 354/1180 - (30%)
• Similarity: 553/1180 - (46%)
• Gaps: 207/1180 - (17%)

  Fly    17 DYID--FNSQLKM--------ETGLHERD--------------RAGVQDFVLLENYQSEEAFIGN 57
            |:.:  |:.:||:        ||...|.|              .....|...| :|.:|.|.:..
Yeast    27 DFFEGTFHLELKLEDGETVSIETNSFENDDDHPTLPVLRNPPILESTDDLTTL-SYLNEPAVLHA 90

  Fly    58 LKKRFQEDLIYTYIGQVLISVNPYKQLP-IYTDDHVKAYRNKHFYEMPPHIFAVTDNAFRSLIEE 121
            :|||:....||||.|.|||:.||:.::. :|:.:.::.|.:|...|:.||:||:.:.|:|.::.|
Yeast    91 IKKRYMNGQIYTYSGIVLIAANPFDKVDHLYSREMIQNYSSKRKDELEPHLFAIAEEAYRFMVHE 155

  Fly   122 NRGQCVLISGESGSGKTEASKKVLQFIAAC--SGN---QTTVEGVKDKLLKSNPVLEAFGNAKTN 181
            ...|.|::|||||:|||.::|.::::.|:.  |.|   :..:..::.::|.:||::||||||||.
Yeast   156 KANQTVVVSGESGAGKTVSAKYIMRYFASVQESNNREGEVEMSQIESQILATNPIMEAFGNAKTT 220

  Fly   182 RNDNSSRFGKYMDIQFDFKGAPIGGNILNYLLEKSRVVAQMGGERNFHIFYQLLAGADEALLQEL 246
            |||||||||||:.|.||......|..|..|||||||:|.|...|||:|||||:|.|..|.:.|||
Yeast   221 RNDNSSRFGKYLQILFDENTTIRGSKIRTYLLEKSRLVYQPETERNYHIFYQILEGLPEPVKQEL 285

  Fly   247 RLERALDTYSYLTDGLNGTVTRINDADSFKQVQQALTVIDFTKEEQREIFGIVASILHLGNVGFT 311
            .|....| |.|...|....:..|::|..:|....||:::....|.|..||.|:|.:||:||:...
Yeast   286 HLSSPKD-YHYTNQGGQPNIAGIDEAREYKITTDALSLVGINHETQLGIFKILAGLLHIGNIEMK 349

  Fly   312 EVEGNAKVNSRDL-VVTAARLLGVNASELEAALTHRTIDARGDVVTSPLNQELAIYARDALAKAV 375
            ....:|.::|.:. :..|..|||::.......:..:.|..|.:.:.:.||...|:.|||::||.:
Yeast   350 MTRNDASLSSEEQNLQIACELLGIDPFNFAKWIVKKQIVTRSEKIVTNLNYNQALIARDSVAKFI 414

  Fly   376 YDRLFSWLVQRLNISLQAKETRASRN--NVMGILDIYGFEIFQKNSFEQFCINFCNEKLQQLFIE 438
            |..||.|||..:|.:|...|.....:  :.:|||||||||.|:||||||||||:.||||||.|.:
Yeast   415 YSTLFDWLVDNINKTLYDPELDQQDHVFSFIGILDIYGFEHFEKNSFEQFCINYANEKLQQEFNQ 479

  Fly   439 LTLKSEQDEYRREGIEWIPVEYFDNKVICNLIEEKHKGIISILDEECLRPGEPTDKTFLEKLTQK 503
            ...|.||:||.:|.|||..:|:.||:...:|||.| .||:|:||||...| ..:|:::..||
Yeast   480 HVFKLEQEEYVKEEIEWSFIEFSDNQPCIDLIENK-LGILSLLDEESRLP-SGSDESWASKL--- 539

  Fly   504 LAQHHHYVCHEKAPAH---IKKIMLRDEFRLVHYAGEVTYSVNGFLDKNNDLLFRDLKETLSKAG 565
                  |....|.|::   .|....:.:|.:.|||.:|.|.|.||::||.|.:.....:......
Yeast   540 ------YSAFNKPPSNEVFSKPRFGQTKFIVSHYAVDVEYEVEGFIEKNRDSVSLGHLDVFKATT 598

  Fly   566 NGIVRNCFPEKELRSLKRPETAITQ-------------------FRASLNNLMDILMCKEPSYIR 611
            |.|.:.....:||||...||...|:                   |:.||..||.|:......|||
Yeast   599 NPIFKQILDNRELRSDDAPEEQNTEKKIMIPARLSQKKPTLGSMFKKSLGELMAIINSTNVHYIR 663

  Fly   612 CIKPNDLQTANVFNDELVLHQVKYLGLMENLRVRRAGFAYRRTYELFLERYKSLSK-STWPN-YK 674
            |||||..:....|::.:||.|::..|::|.:|:..|||..|.|::.|::||..|:. |.|.. ..
Yeast   664 CIKPNSEKKPWEFDNLMVLSQLRACGVLETIRISCAGFPSRWTFDEFVQRYFLLTDYSLWSGILY 728

  Fly   675 GPGGPKAGV----QQLVKDLGWDEEKYRVGETKLFIRWPRTLFDTEDAYQEKKHEIAAIIQAHWK 735
            .|..||..:    |.::.....|..||::|.||:|.:.....| .|.....|.:||..|||...:
Yeast   729 NPDLPKEAIVNFCQSILDATISDSAKYQIGNTKIFFKAGMLAF-LEKLRTNKMNEICIIIQKKIR 792

  Fly   736 GLMQRRKY--------------------------LKLRA----------------------QVII 752
            ....|.:|                          ||.||                      |:|.
Yeast   793 ARYYRLQYLQTMESIKKCQSQIRSLLVRTRVDHELKTRAAILLQTNIRALWKREYYRAAIGQIIK 857

  Fly   753 MQSYCRRKLAQQAAKKR--REAADKIRAFIKGFITRNDAPNGFNEEF---------IANAKRMWL 806
            :|..|:|||...:..::  ..||..|:::|:.:        |...::         :.:|.||.|
Yeast   858 LQCTCKRKLILDSVNRKFMLMAAVIIQSYIRSY--------GHKTDYRTLKRSSILVQSAMRMQL 914

  Fly   807 LR-----LAKELPTKVLDKSWPHAPGHCEEA----SGILHRLHRLH--LARIYRL------KLTP 854
            .|     |.||:..:.:..|  :..|..|||    :..:..|..|:  ..|:.:|      .:..
Yeast   915 ARRRYIVLQKEVEERNIRAS--YGIGLLEEAIEFKNSFILNLEMLNDSYTRLTQLLQGDLSNIPS 977

  Fly   855 QQKRQFELKVLAEKVFKGKKNNYASSVSTWFQEDRIPKEHIQRVNDFVASTFGSEQLKYQSFCTK 919
            :|::::|..|          |.|...:|      ::....::.:|.........|:.|.||...:
Yeast   978 KQRQEYETIV----------NGYNDKIS------KLKTLQVEIMNTLNKKNALKERKKKQSSLIQ 1026

  Fly   920 FDRHGYKSRDRFILLSNKAIYVLDG-KTYKQKHRLPLDKI--DFTLT---NHNDDLMVIRIPLDL 978
            .......:     :..||...:.|. |:.||:.....:.|  |||.|   |.||.:..:.|....
Yeast  1027 SHMQSLAA-----IKGNKPSRLSDEVKSMKQELAFIENVIAQDFTTTYSANKNDKVKGLGIAGQQ 1086

  Fly   979 KKDKGDLILIIPR----------IIEFSTYIID-TVGTASIVSIVDRNSLEHNVVKGKGGVIDIQ 1032
            .|.|  |:.:|.|          :::.:.|.:: |.|....|::.:.|.  .||:    |.|.:.
Yeast  1087 VKPK--LVNVIRRESGNPDLLELLMDLNCYTLEVTEGYLKKVNVTEVNG--DNVL----GPIHVI 1143

  Fly  1033 TGAEPGVVRD 1042
            |.....:||:
Yeast  1144 TTVVSSLVRN 1153

Known Domains

Gene	Sequence	Domain	Region	External ID	Identity
Myo61F	NP_476934.2	MYSc	32..720	CDD:214580	264/738 (36%)
		MYSc_Myo1	52..707	CDD:276829	256/691 (37%)
		Myosin_TH1	863..1035	CDD:283635	39/188 (21%)
MYO4	NP_009373.1	COG5022	2..1471	CDD:227355	354/1180 (30%)

Information from Original Tools

Tool	Simple Score	Weighted Score	Original Tool Information
			BLAST Result	Score	Score Type	Cluster ID
Compara	0	0.000	Not matched by this tool.
Domainoid	0	0.000	Not matched by this tool.
eggNOG	0	0.000	Not matched by this tool.
Hieranoid	0	0.000	Not matched by this tool.
Homologene	0	0.000	Not matched by this tool.
Inparanoid	0	0.000	Not matched by this tool.
Isobase	0	0.000	Not matched by this tool.
OMA	0	0.000	Not matched by this tool.
OrthoFinder	0	0.000	Not matched by this tool.
OrthoInspector	0	0.000	Not matched by this tool.
orthoMCL	0	0.000	Not matched by this tool.
Panther	0	0.000	Not matched by this tool.
Phylome	1	0.910	-	-
RoundUp	0	0.000	Not matched by this tool.
SonicParanoid	0	0.000	Not matched by this tool.
TreeFam	0	0.000	Not matched by this tool.
	1	0.910